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1.发明授权Multispecific antibodies comprising full length antibodies and single chain fab fragments 有权包含全长抗体和单链Fab片段的多特异性抗体公开(公告)号：US09382323B2
公开(公告)日：2016-07-05
申请号：US12750748
申请日：2010-03-31
申请人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及包含全长抗体和单链Fab片段的多特异性，特别是双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US20100256339A1
公开(公告)日：2010-10-07
申请号：US12752196
申请日：2010-04-01
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/468 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-3和针对人c-Met的双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US20120149879A1
公开(公告)日：2012-06-14
申请号：US13330724
申请日：2011-12-20
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
IPC分类号： C07K16/46
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies.
摘要翻译： 本发明涉及针对EGFR和针对IGF-1R的双特异性抗体，其制备方法，含有所述抗体的药物组合物和使用该抗体的治疗方法。
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公开(公告)号：US20110086026A1
公开(公告)日：2011-04-14
申请号：US12843225
申请日：2010-07-26
申请人： Josef Endl , Maria Elena Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Thomas Regula , Ralf Schumacher , Stefan Seeber , Jan Olaf Stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
发明人： Josef Endl , Maria Elena Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Thomas Regula , Ralf Schumacher , Stefan Seeber , Jan Olaf Stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
IPC分类号： A61K39/395 , C07H21/00 , C07K16/00 , A61P11/06 , A61P37/02 , C12N5/10 , C12P21/02 , C12N15/63 , C12N1/00
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： An antibody binding to IL-13Rα1, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of said antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9 is useful in the treatment of asthma and allergic diseases.
摘要翻译： 与IL-13Rα1结合的抗体，抑制IL-13生物活性并包含可变重链和可变轻链的抗体，其特征在于所述抗体的可变重链氨基酸序列CDR3选自重链CDR3序列 的SEQ ID NO：1,3,5,7或9可用于治疗哮喘和过敏性疾病。
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5.发明申请COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 有权复合抗生素和联合治疗或诊断代谢物的双特异性抗体公开(公告)号：US20120269723A1
公开(公告)日：2012-10-25
申请号：US13382502
申请日：2010-07-05
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffman , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffman , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途， 含有所述抗体的药物组合物及其用途。
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6.发明申请公开(公告)号：US20100256338A1
公开(公告)日：2010-10-07
申请号：US12750748
申请日：2010-03-31
申请人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pabio Umana
发明人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pabio Umana
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及包含全长抗体和单链Fab片段的多特异性，特别是双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US07807158B2
公开(公告)日：2010-10-05
申请号：US11325197
申请日：2006-01-03
申请人： Josef Endl , Maria Elena Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Thomas Regula , Ralf Schumacher , Stefan Seeber , Jan Olaf Stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
发明人： Josef Endl , Maria Elena Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Thomas Regula , Ralf Schumacher , Stefan Seeber , Jan Olaf Stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： The instant specification discloses an antibody binding to IL-13Rα1, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of this antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9, and this antibody is useful in the treatment of asthma and allergic diseases.
摘要翻译： 本说明书公开了结合IL-13Rα1的抗体，抑制IL-13生物活性并包含可变重链和可变轻链，其特征在于该抗体的可变重链氨基酸序列CDR3选自 SEQ ID NO：1,3,5,7或9的重链CDR3序列，该抗体可用于治疗哮喘和过敏性疾病。
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8.发明授权Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent 有权缀合于治疗或诊断剂的双特异性抗体和地高辛的复合物公开(公告)号：US08907069B2
公开(公告)日：2014-12-09
申请号：US13382502
申请日：2010-07-05
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/46 , A61K51/10 , A61K49/00 , A61K47/48 , C07K16/28 , B82Y5/00 , C12N15/113 , A61K39/395 , C07K16/16 , C07K16/44 , C07K16/32 , C12N15/11 , A61K31/704 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途， 含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120282280A1
公开(公告)日：2012-11-08
申请号：US13382505
申请日：2010-06-30
申请人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffman , Ludger Markus Ickenstein , Kerstin Jahn-Hofman , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffman , Ludger Markus Ickenstein , Kerstin Jahn-Hofman , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原是PEG或生物素，最优选地高辛，其制备方法，它们作为治疗或诊断剂的递送平台的用途，含有 所述抗体及其用途。
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公开(公告)号：US09050375B2
公开(公告)日：2015-06-09
申请号：US13382505
申请日：2010-06-30
申请人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/46 , A61K49/00 , A61K49/16 , A61K47/48 , A61K31/704 , A61K39/395 , B82Y5/00 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C12N15/11 , C12N15/113 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原为PEG或生物素，最优选为地高辛，其制备方法，用作治疗或诊断试剂的递送平台，含有所述 抗体及其用途。
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