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公开(公告)号：US08883159B2
公开(公告)日：2014-11-11
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
IPC分类号： A61K39/395 , A61P35/04 , C07K16/30 , C07K16/28 , C12N15/13 , C12N15/85 , C12N5/10 , A61K39/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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公开(公告)号：US20100254988A1
公开(公告)日：2010-10-07
申请号：US12753141
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-2 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-2和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US20110070246A1
公开(公告)日：2011-03-24
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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公开(公告)号：US08394928B2
公开(公告)日：2013-03-12
申请号：US12868845
申请日：2010-08-26
申请人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
发明人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CDCP1（抗CDCP1抗体）的人源化抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20100254989A1
公开(公告)日：2010-10-07
申请号：US12753145
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-1 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-1和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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6.发明申请RECOMBINANT FC-FUSION PROTEIN OF THE FIFTH FIBRONECTIN TYPE III DOMAIN OF DCC 审中-公开DCC第五类FIBRONECTIN III型域的重组FC融合蛋白公开(公告)号：US20130336972A1
公开(公告)日：2013-12-19
申请号：US13818465
申请日：2011-08-26
申请人： Christian Klein , Erhard Kopetzki , Gerhard Niederfellner , Agnes Bernet , Celine Delloye-Bourgeois , Patrick Mehlen
发明人： Christian Klein , Erhard Kopetzki , Gerhard Niederfellner , Agnes Bernet , Celine Delloye-Bourgeois , Patrick Mehlen
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K14/70503 , C07K2319/30
摘要： The present invention relates to DCC-fusion proteins, nucleic acid molecules encoding the DCC-fusion proteins, as well as methods for their production and their use in treatment of cancer such as colorectal cancer, NSCLC and metastatic breast cancer. The present invention also relates to methods of treating cancer such as colorectal cancer, NSCLC and metastatic breast cancer by administering DCC-fusion proteins.
摘要翻译： 本发明涉及DCC融合蛋白，编码DCC-融合蛋白的核酸分子及其生产方法及其在治疗癌症如结肠直肠癌，NSCLC和转移性乳腺癌中的应用。 本发明还涉及通过施用DCC-融合蛋白来治疗癌症如结肠直肠癌，NSCLC和转移性乳腺癌的方法。
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公开(公告)号：US20110052582A1
公开(公告)日：2011-03-03
申请号：US12868845
申请日：2010-08-26
申请人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
发明人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00
CPC分类号： C07K16/30 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CDCP1（抗CDCP1抗体）的人源化抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20100256339A1
公开(公告)日：2010-10-07
申请号：US12752196
申请日：2010-04-01
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/468 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-3和针对人c-Met的双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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