-
公开(公告)号：US09194877B2
公开(公告)日：2015-11-24
申请号：US12837191
申请日：2010-07-15
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson , Ronald K. Bergold , Robert D. Miller , Kevin S. Oberkramer
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson , Ronald K. Bergold , Robert D. Miller , Kevin S. Oberkramer
CPC分类号： C12Q1/686 , B01L7/52 , C12Q1/6806 , G01N27/72 , G01N35/00871 , G01N35/0092 , G01N35/0095 , G01N35/0098 , G01N35/025 , G01N35/026 , G01N2035/00534
摘要： The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.
摘要翻译： 本发明提供用于分析样品，特别是生物和环境样品以检测其中所含感兴趣的生物分子的系统和方法。 本文描述了各种系统组件，包括但不限于用于样品处理，材料混合，样品处理，材料转移和材料分析的组件。 本发明还提供了用于组合和集成不同部件并且用于整体地容纳，移动和存储系统部件或系统的机构。 这些系统可以包括这些组件中的任何一个或多个或全部。 当使用质谱法分析核酸分子时，该系统特别有用，但本发明不限于此。
-
2.发明授权Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权线粒体DNA快速法医分析方法及线粒体DNA异质性表征公开(公告)号：US08802372B2
公开(公告)日：2014-08-12
申请号：US11929930
申请日：2007-10-30
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
-
公开(公告)号：US08563250B2
公开(公告)日：2013-10-22
申请号：US11682259
申请日：2007-03-05
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
-
4.发明申请Method for Rapid Detection and Identification of Bioagents in Epidemiological and Forensic Investigations 有权在流行病学和法医学调查中快速检测和鉴定生物标本的方法公开(公告)号：US20120171679A1
公开(公告)日：2012-07-05
申请号：US11930741
申请日：2007-10-31
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
-
公开(公告)号：US20120190016A1
公开(公告)日：2012-07-26
申请号：US13257234
申请日：2010-03-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y02A50/451
摘要： The present invention relates generally to identification of Salmonella enterica bacteria or strains of Salmonella enterica, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
摘要翻译： 本发明一般涉及肠粘菌沙门氏菌或肠炎沙门氏菌菌株的鉴定，并提供了用于此目的的方法，组合物和试剂盒，例如用分子量或碱组成分析组合时。
-
公开(公告)号：US20120115213A1
公开(公告)日：2012-05-10
申请号：US12837191
申请日：2010-07-15
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared H. Nathanson , Ronald K. Bergold , Robert D. Miller , Kevin S. Oberkramer
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared H. Nathanson , Ronald K. Bergold , Robert D. Miller , Kevin S. Oberkramer
CPC分类号： C12Q1/686 , B01L7/52 , C12Q1/6806 , G01N27/72 , G01N35/00871 , G01N35/0092 , G01N35/0095 , G01N35/0098 , G01N35/025 , G01N35/026 , G01N2035/00534
摘要： The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.
摘要翻译： 本发明提供用于分析样品，特别是生物和环境样品以检测其中所含感兴趣的生物分子的系统和方法。 本文描述了各种系统组件，包括但不限于用于样品处理，材料混合，样品处理，材料转移和材料分析的组件。 本发明还提供了用于组合和集成不同部件并且用于整体地容纳，移动和存储系统部件或系统的机构。 这些系统可以包括这些组件中的任何一个或多个或全部。 当使用质谱法分析核酸分子时，该系统特别有用，但本发明不限于此。
-
公开(公告)号：US20110250648A1
公开(公告)日：2011-10-13
申请号：US13081272
申请日：2011-04-06
CPC分类号： C12P19/34 , C07K14/4703 , C07K14/5406 , C12Q1/686 , C12Q2521/131 , C12Q2525/161 , C12Q2527/125 , C12Q2565/627
摘要： The present invention relates to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction). In addition, systems and methods are provided for generating amplified products generated with polynucleotide amplification techniques having reduced 3′ non-templated nucleotide addition.
摘要翻译： 本发明涉及用于扩增核酸的系统和方法。 特别地，提供了用于在多核苷酸扩增设置（例如，聚合酶链式反应）内抑制基于聚合酶的末端转移酶活性的系统和方法。 此外，提供了用于产生用具有减少的3'非模板核苷酸添加的多核苷酸扩增技术产生的扩增产物的系统和方法。
-
公开(公告)号：US20110200997A1
公开(公告)日：2011-08-18
申请号：US12995427
申请日：2009-05-29
申请人： Sherilynn Manalili Wheeler , James C. Hannis , Feng Li , Raymond Ranken , Lawrence B. Blyn , David J. Ecker , Rangarajian Sampath , Steven A. Hofstadler
发明人： Sherilynn Manalili Wheeler , James C. Hannis , Feng Li , Raymond Ranken , Lawrence B. Blyn , David J. Ecker , Rangarajian Sampath , Steven A. Hofstadler
CPC分类号： C12Q1/689
摘要： The present invention relates generally to identification of enteric bacterial pathogens, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
摘要翻译： 本发明一般涉及肠道细菌病原体的鉴定，并且提供了用于此目的的方法，组合物和试剂盒，例如当与分子量或碱组成分析组合时。
-
9.发明授权Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations 有权在流行病学和法医学调查中快速检测和鉴定生物标本的方法公开(公告)号：US07226739B2
公开(公告)日：2007-06-05
申请号：US10660997
申请日：2003-09-12
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
-
10.发明授权公开(公告)号：US09068017B2
公开(公告)日：2015-06-30
申请号：US13081272
申请日：2011-04-06
CPC分类号： C12P19/34 , C07K14/4703 , C07K14/5406 , C12Q1/686 , C12Q2521/131 , C12Q2525/161 , C12Q2527/125 , C12Q2565/627
摘要： The present invention relates to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction). In addition, systems and methods are provided for generating amplified products generated with polynucleotide amplification techniques having reduced 3′ non-templated nucleotide addition.
摘要翻译： 本发明涉及用于扩增核酸的系统和方法。 特别地，提供了用于在多核苷酸扩增设置（例如，聚合酶链式反应）内抑制基于聚合酶的末端转移酶活性的系统和方法。 此外，提供了用于产生用具有减少的3'非模板核苷酸添加的多核苷酸扩增技术产生的扩增产物的系统和方法。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.036 秒)
