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公开(公告)号：US09267099B2
公开(公告)日：2016-02-23
申请号：US13635043
申请日：2011-03-15
CPC分类号： C12M21/08 , A61K35/44 , C12M23/10 , C12M23/20 , C12N5/0068 , C12N2533/90
摘要： Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.
摘要翻译： 本文公开了包括支撑介质内的活细胞的毛细管制造装置。 细胞的培养产生具有天然或预定几何形状的可行的管腔毛细血管网络，以及与毛细管网络相关联的ECM和基底膜。 毛细管网络和可从毛细管网络拆卸的ECM和基底膜可用于组织工程应用。
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公开(公告)号：US20110257494A1
公开(公告)日：2011-10-20
申请号：US13158502
申请日：2011-06-13
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
IPC分类号： A61B5/1455
CPC分类号： G01N21/05 , B82Y15/00 , B82Y30/00 , G01N21/554 , G01N2021/0346
摘要： Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
摘要翻译： 提供了将样品和试剂流的微流控制和微腔表面等离子体共振传感器结合在一起的可穿戴或可植入装置，其具有能够特异性结合体内目标分析物，配体或分子的表面处理或涂层功能化。 该装置可用于确定体液中目标分析物的存在和浓度，从而有助于诊断，监测或检测疾病状况的变化。
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公开(公告)号：US07852482B2
公开(公告)日：2010-12-14
申请号：US12751090
申请日：2010-03-31
申请人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
发明人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。
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公开(公告)号：US4578927A
公开(公告)日：1986-04-01
申请号：US441251
申请日：1982-11-12
申请人： Eric W. Scarpa , James A. Glazier
发明人： Eric W. Scarpa , James A. Glazier
CPC分类号： B65B35/205 , B65B57/06
摘要： A barrel loader for a cartoner having a product conveyor and a carton conveyor. A plurality of pusher heads are carried on two spaced endless chains. A cam track between the chains cooperates with cam followers on the heads to cam the heads toward the product conveyor to thrust product into the cartons. A switch on the cam track diverts a pusher head from the cam track upon detecting the absence of a carton with which the pusher head is associated.
摘要翻译： 用于装有产品输送机和纸箱输送机的纸箱的桶式装载机。 多个推动头承载在两个间隔开的环形链上。 链条之间的凸轮轨道与头部上的凸轮从动件配合，将头部朝向产品输送机凸轮，将产品推入纸箱中。 当检测到没有与推动头相关联的纸箱时，凸轮轨道上的开关将推动头从凸轮轨道转移。
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公开(公告)号：US09440207B2
公开(公告)日：2016-09-13
申请号：US12678237
申请日：2008-09-18
CPC分类号： B01L3/502715 , B01F3/0865 , B01F5/06 , B01F5/0601 , B01F13/0059 , B01F13/0062 , B01F15/0404 , B01F2003/0896 , B01F2215/0037 , B01L3/502776 , B01L2200/0694 , B01L2200/12 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415
摘要： Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.
摘要翻译： 公开了一种用于操纵流体的方法和装置。 该装置可以包括微流体结构，其包括取向于分叉（5），三叉（6）和（3）的入口通道（1和2）和出口通道（306,307,308,309,310,311,312,313和314） 合并路口（7和8）。 该装置分裂和合并在通道中流动的流体以在出口通道内产生连续稀释的流体。 多个装置可以串联，并联，组合的串行和并行和/或堆叠配置组合。 一个或多个装置可以单独使用或者为稀释流体提供各种装置或室。
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公开(公告)号：US07961330B2
公开(公告)日：2011-06-14
申请号：US12751101
申请日：2010-03-31
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。
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公开(公告)号：US07961329B2
公开(公告)日：2011-06-14
申请号：US12751099
申请日：2010-03-31
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multichannel sensor for detecting the presence of several targets with a single microchip sensor is described. A multichannel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了包括通常功能化为几个目标之一的SPR元件的集合的多通道传感器。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。
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公开(公告)号：US5579894A
公开(公告)日：1996-12-03
申请号：US420108
申请日：1995-04-11
CPC分类号： B65H33/16 , B65B35/44 , B65B57/16 , B65G23/30 , B65H2701/191
摘要： A product transfer apparatus for transferring individual product from a rotary feeding station to downstream apparatus such as a cartoner conveyor in preselected count stacks for subsequent discharge at a cartoner machine. Stacks of product are formed by dropping the product into stacks on a transfer conveyor and from there dropping the stacks directly into buckets of a cartoner conveyor. A transfer bucket conveyor is disposed beneath and transverse to an axis of the rotary feeding station and includes an upper fill run and a lower discharge run of product transfer buckets. The cartoner conveyor is disposed beneath and aligned with the transfer bucket conveyor and includes a series of cartoner product buckets operating in speed register with the lower run of product transfer buckets for receiving the preselected count stacks from the lower discharge run. The transfer bucket conveyor is capable of intermittent or decreased speed in the upper fill run for accommodating stack building, rejection of the product, varied product sizes, varying counts of the product in the upper fill run, a varied bucket pitch, while maintaining a constant speed in the lower discharge run for continuously feeding product stacks to the cartoner product buckets. Any combination of continuous and intermittent motion in the upper and lower transfer runs can be used for desired effect, including synchronization between varied upstream and downstream product handling stations.
摘要翻译： 一种产品传送装置，用于将单个产品从旋转进给站传送到下游装置，例如预选计数堆叠中的纸箱输送机，用于随后在纸箱机上排出。 通过将产品放置在传送输送机上的堆叠中并从那里将堆叠物直接放入纸箱输送机的桶中而形成产品堆。 输送斗式输送机设置在旋转进给站的轴线的下方并横向于轴线，并且包括产品输送桶的上部填充运行和下部排出流程。 纸箱输送机设置在转印斗输送机下方并与转印斗输送机对准，并且包括一系列在速度寄存器中操作的纸箱产品桶，其具有用于从较低排出流程接收预选计数堆叠的产品转移桶的下游。 输送斗式输送机能够在上部填充运行中间歇或降低速度，以容纳堆叠建筑物，产品的排除，不同的产品尺寸，上部填充运行中的产品的变化计数，不同的料斗间距，同时保持恒定 在较低的排放运行中的速度，用于将产品堆叠连续供给到纸箱产品桶。 在上下传输运行中的连续和间歇运动的任何组合可以用于期望的效果，包括不同的上游和下游产品处理站之间的同步。
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公开(公告)号：US08355136B2
公开(公告)日：2013-01-15
申请号：US13158502
申请日：2011-06-13
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
CPC分类号： G01N21/05 , B82Y15/00 , B82Y30/00 , G01N21/554 , G01N2021/0346
摘要： Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
摘要翻译： 提供了将样品和试剂流的微流控制和微腔表面等离子体共振传感器结合在一起的可穿戴或可植入装置，其具有能够特异性结合体内目标分析物，配体或分子的表面处理或涂层功能化。 该装置可用于确定体液中目标分析物的存在和浓度，从而有助于诊断，监测或检测疾病状况的变化。
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公开(公告)号：US20100189603A1
公开(公告)日：2010-07-29
申请号：US12751090
申请日：2010-03-31
申请人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
发明人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
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