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    Sub-micron surface plasmon resonance sensor systems
    2.
    发明授权
    Sub-micron surface plasmon resonance sensor systems 有权
    亚微米表面等离子体共振传感器系统

    公开(公告)号：US07852482B2

    公开(公告)日：2010-12-14

    申请号：US12751090

    申请日：2010-03-31

    申请人： James A. Glazier ,  Bogdan Dragnea ,  Dragos Amarie

    发明人： James A. Glazier ,  Bogdan Dragnea ,  Dragos Amarie

    IPC分类号： G01N21/55

    CPC分类号： G01N21/554 ,  B01L3/5027 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/05 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/0346

    摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.

    摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。

    Sub-micron surface plasmon resonance sensor systems
    3.
    发明授权
    Sub-micron surface plasmon resonance sensor systems 有权
    亚微米表面等离子体共振传感器系统

    公开(公告)号：US07724373B2

    公开(公告)日：2010-05-25

    申请号：US11611509

    申请日：2006-12-15

    申请人： James A. Glazier ,  Bogdan Dragnea ,  Dragos Amarie

    发明人： James A. Glazier ,  Bogdan Dragnea ,  Dragos Amarie

    IPC分类号： G01N21/55

    CPC分类号： G01N21/554 ,  B01L3/5027 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/05 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/0346

    摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.

    摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。

    Sub-Micron Surface Plasmon Resonance Sensor Systems
    4.
    发明申请
    Sub-Micron Surface Plasmon Resonance Sensor Systems 有权
    亚微米表面等离子体共振传感器系统

    公开(公告)号：US20070153284A1

    公开(公告)日：2007-07-05

    申请号：US11611509

    申请日：2006-12-15

    申请人： James Glazier ,  Bogdan Dragnea ,  Dragos Amarie

    发明人： James Glazier ,  Bogdan Dragnea ,  Dragos Amarie

    IPC分类号： G01N21/55

    CPC分类号： G01N21/554 ,  B01L3/5027 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/05 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/0346

    摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprises a light transmissive substrate, an array of surface plasmon resonant (SPR) elements mounted thereon, a light source arranged to direct light into the SPR elements, and a detector arranged to detect light transmitted through the SPR elements. The SPR elements may include a dielectric polystyrene sphere having a spherical diameter of about 770 nm with a gold coating layer about 150 nm thick. The interface between the SPR elements and the substrate forms a pinhole with a diameter less than the wavelength of the light directed into the elements to produce a near-field coupling mode within the micro-sized SPR elements. In specific embodiments, the pinhole diameter ranges between 150-200 nm. The SPR elements are contained within a molded PDMS chip that may incorporate micro-fluidic components, such as a pump and valves, to control flow of the test fluid across the SPR elements. A multi-channel sensor may be provided for detecting the presence of several targets with a single micro-chip sensor. In the multi-channel sensor collections of SPR elements are commonly functionalized to one of the several targets. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.

    摘要翻译： 用于检测测试流体中目标分析物，配体或分子的存在的传感器包括透光基板，安装在其上的表面等离子体共振（SPR）元件的阵列，被布置成将光引导到SPR元件中的光源， 以及检测器，被布置成检测透过SPR元件的光。 SPR元件可以包括球形直径约770nm的电介质聚苯乙烯球，金涂层约150nm厚。 SPR元件和衬底之间的界面形成了一个直径小于被引入元件的光的波长的针孔，以在微尺寸SPR元件内产生近场耦合模式。 在具体实施例中，针孔直径在150-200nm之间。 SPR元件包含在模制的PDMS芯片中，其可以结合微流体组件，例如泵和阀，以控制跨越SPR元件的测试流体的流动。 可以提供多通道传感器，用于利用单个微芯片传感器来检测几个目标的存在。 在SPR元件的多通道传感器集合中，通常将功能化到多个目标之一。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。

    SUB-MICRON SURFACE PLASMON RESONANCE SENSOR SYSTEMS
    6.
    发明申请
    SUB-MICRON SURFACE PLASMON RESONANCE SENSOR SYSTEMS 有权
    子麦克风表面等离子体共振传感器系统

    公开(公告)号：US20110257494A1

    公开(公告)日：2011-10-20

    申请号：US13158502

    申请日：2011-06-13

    申请人： James A. Glazier ,  Dragos Amarie

    发明人： James A. Glazier ,  Dragos Amarie

    IPC分类号： A61B5/1455

    CPC分类号： G01N21/05 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/554 ,  G01N2021/0346

    摘要： Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.

    摘要翻译： 提供了将样品和试剂流的微流控制和微腔表面等离子体共振传感器结合在一起的可穿戴或可植入装置，其具有能够特异性结合体内目标分析物，配体或分子的表面处理或涂层功能化。 该装置可用于确定体液中目标分析物的存在和浓度，从而有助于诊断，监测或检测疾病状况的变化。

    Sub-micron surface plasmon resonance sensor systems
    7.
    发明授权
    Sub-micron surface plasmon resonance sensor systems 有权
    亚微米表面等离子体共振传感器系统

    公开(公告)号：US08355136B2

    公开(公告)日：2013-01-15

    申请号：US13158502

    申请日：2011-06-13

    申请人： James A. Glazier ,  Dragos Amarie

    发明人： James A. Glazier ,  Dragos Amarie

    IPC分类号： G01N21/55 ,  A61B5/145

    CPC分类号： G01N21/05 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/554 ,  G01N2021/0346

    摘要： Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.

    摘要翻译： 提供了将样品和试剂流的微流控制和微腔表面等离子体共振传感器结合在一起的可穿戴或可植入装置，其具有能够特异性结合体内目标分析物，配体或分子的表面处理或涂层功能化。 该装置可用于确定体液中目标分析物的存在和浓度，从而有助于诊断，监测或检测疾病状况的变化。

    SUB-MICRON SURFACE PLASMON RESONANCE SENSOR SYSTEMS
    8.
    发明申请
    SUB-MICRON SURFACE PLASMON RESONANCE SENSOR SYSTEMS 有权
    子麦克风表面等离子体共振传感器系统

    公开(公告)号：US20100188664A1

    公开(公告)日：2010-07-29

    申请号：US12751101

    申请日：2010-03-31

    申请人： James A. Glazier ,  Dragos Amarie

    发明人： James A. Glazier ,  Dragos Amarie

    IPC分类号： G01N21/55

    CPC分类号： G01N21/554 ,  B01L3/5027 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/05 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/0346

    摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.

    摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。

    Sub-micron surface plasmon resonance sensor systems
    10.
    发明授权
    Sub-micron surface plasmon resonance sensor systems 有权
    亚微米表面等离子体共振传感器系统

    公开(公告)号：US07961330B2

    公开(公告)日：2011-06-14

    申请号：US12751101

    申请日：2010-03-31

    申请人： James A. Glazier ,  Dragos Amarie

    发明人： James A. Glazier ,  Dragos Amarie

    IPC分类号： G01N21/55

    CPC分类号： G01N21/554 ,  B01L3/5027 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/05 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/0346

    摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.

    摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。