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公开(公告)号：US4578927A
公开(公告)日：1986-04-01
申请号：US441251
申请日：1982-11-12
申请人： Eric W. Scarpa , James A. Glazier
发明人： Eric W. Scarpa , James A. Glazier
CPC分类号： B65B35/205 , B65B57/06
摘要： A barrel loader for a cartoner having a product conveyor and a carton conveyor. A plurality of pusher heads are carried on two spaced endless chains. A cam track between the chains cooperates with cam followers on the heads to cam the heads toward the product conveyor to thrust product into the cartons. A switch on the cam track diverts a pusher head from the cam track upon detecting the absence of a carton with which the pusher head is associated.
摘要翻译： 用于装有产品输送机和纸箱输送机的纸箱的桶式装载机。 多个推动头承载在两个间隔开的环形链上。 链条之间的凸轮轨道与头部上的凸轮从动件配合，将头部朝向产品输送机凸轮，将产品推入纸箱中。 当检测到没有与推动头相关联的纸箱时，凸轮轨道上的开关将推动头从凸轮轨道转移。
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公开(公告)号：US08355136B2
公开(公告)日：2013-01-15
申请号：US13158502
申请日：2011-06-13
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
CPC分类号： G01N21/05 , B82Y15/00 , B82Y30/00 , G01N21/554 , G01N2021/0346
摘要： Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
摘要翻译： 提供了将样品和试剂流的微流控制和微腔表面等离子体共振传感器结合在一起的可穿戴或可植入装置，其具有能够特异性结合体内目标分析物，配体或分子的表面处理或涂层功能化。 该装置可用于确定体液中目标分析物的存在和浓度，从而有助于诊断，监测或检测疾病状况的变化。
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公开(公告)号：US20100189603A1
公开(公告)日：2010-07-29
申请号：US12751090
申请日：2010-03-31
申请人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
发明人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
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公开(公告)号：US20100188664A1
公开(公告)日：2010-07-29
申请号：US12751101
申请日：2010-03-31
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。
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公开(公告)号：US09267099B2
公开(公告)日：2016-02-23
申请号：US13635043
申请日：2011-03-15
CPC分类号： C12M21/08 , A61K35/44 , C12M23/10 , C12M23/20 , C12N5/0068 , C12N2533/90
摘要： Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.
摘要翻译： 本文公开了包括支撑介质内的活细胞的毛细管制造装置。 细胞的培养产生具有天然或预定几何形状的可行的管腔毛细血管网络，以及与毛细管网络相关联的ECM和基底膜。 毛细管网络和可从毛细管网络拆卸的ECM和基底膜可用于组织工程应用。
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公开(公告)号：US20110257494A1
公开(公告)日：2011-10-20
申请号：US13158502
申请日：2011-06-13
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
IPC分类号： A61B5/1455
CPC分类号： G01N21/05 , B82Y15/00 , B82Y30/00 , G01N21/554 , G01N2021/0346
摘要： Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
摘要翻译： 提供了将样品和试剂流的微流控制和微腔表面等离子体共振传感器结合在一起的可穿戴或可植入装置，其具有能够特异性结合体内目标分析物，配体或分子的表面处理或涂层功能化。 该装置可用于确定体液中目标分析物的存在和浓度，从而有助于诊断，监测或检测疾病状况的变化。
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公开(公告)号：US07852482B2
公开(公告)日：2010-12-14
申请号：US12751090
申请日：2010-03-31
申请人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
发明人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。
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公开(公告)号：US08169615B2
公开(公告)日：2012-05-01
申请号：US13116491
申请日：2011-05-26
申请人： James A. Glazier , Dragos Amarie
发明人： James A. Glazier , Dragos Amarie
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。
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公开(公告)号：US07724373B2
公开(公告)日：2010-05-25
申请号：US11611509
申请日：2006-12-15
申请人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
发明人： James A. Glazier , Bogdan Dragnea , Dragos Amarie
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5027 , B82Y15/00 , B82Y30/00 , G01N21/05 , G01N21/553 , G01N33/54373 , G01N2021/0346
摘要： A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.
摘要翻译： 一种用于检测测试流体中目标分析物，配体或分子的存在的传感器，其包括其上安装有表面等离子体共振（SPR）元件阵列的透光基板。 描述了用于利用单个微芯片传感器检测几个目标的存在的多通道传感器。 还描述了多通道传感器，其包括通常功能化为多个目标之一的SPR元件的集合。 检测器感测指示与靶标结合的SPR元件的共振响应的变化。
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公开(公告)号：US20130004469A1
公开(公告)日：2013-01-03
申请号：US13635043
申请日：2011-03-15
CPC分类号： C12M21/08 , A61K35/44 , C12M23/10 , C12M23/20 , C12N5/0068 , C12N2533/90
摘要： Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.
摘要翻译： 本文公开了包括支撑介质内的活细胞的毛细管制造装置。 细胞的培养产生具有天然或预定几何形状的可行的管腔毛细血管网络，以及与毛细管网络相关联的ECM和基底膜。 毛细管网络和可从毛细管网络拆卸的ECM和基底膜可用于组织工程应用。
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