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公开(公告)号：US20240192233A1
公开(公告)日：2024-06-13
申请号：US18552385
申请日：2022-03-25
申请人： FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
CPC分类号： G01N33/743 , G01N2021/1761 , G01N21/31 , G01N2333/723 , G01N2500/20
摘要： The present invention provides a drug discovery assay to screen for compounds capable of modulating condensates based on the ability of the said compounds to shift the condensation propensity of a studied target, preferably an intrinsically disordered protein.
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公开(公告)号：US20240133821A1
公开(公告)日：2024-04-25
申请号：US18402009
申请日：2024-01-02
IPC分类号： G01N21/87 , G01N21/3563 , G01N21/88 , G06N3/045
CPC分类号： G01N21/87 , G01N21/3563 , G01N21/8851 , G06N3/045 , G01N2021/3595
摘要： Identifying 3D objects A method for identification of 3D objects comprises illuminating at least part of a 3D object with electromagnetic radiation, spectroscopically obtaining spectral data for one or more regions of the 3D object, and generating, at a data processing apparatus, an identification result for the 3D object using a trained machine learning model. The trained machine learning model processes the obtained spectral data for the one or more regions to generate one or more model outputs from which the identification result is derived.
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公开(公告)号：US11943548B2
公开(公告)日：2024-03-26
申请号：US17264426
申请日：2019-08-02
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , UNIVERSITAT AUTÒNOMA DE BARCELONA , FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA (ICN2) , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
发明人： Anton Guimerà Brunet , Lluis Antoni Terés Terés , Michele Dei , Jose Agustín Cisneros Fernández , Francisco Serra Graells , José Antonio Garrido Ariza
摘要： An apparatus and a method using no switching elements for multiplexing and reading arrays of sensors whose electrical resistance is modulated by the signals to be measured are proposed. Sensor elements are arranged in groups and columns where each column is fed with a continuous voltage waveform of different amplitude, frequency and phase characteristics which then produce current signals that are modulated by the variable resistance signals to be measured. Modulated currents are summed row-wise and collected at the read-out circuits, either by applying a constant voltage to each row of the array or by connecting a capacitor and converting these current summations into output voltage signals. The read-out circuits de-multiplex each individual sensor signal to be measured by lock-in demodulation according to the frequencies and phases employed for the stimulation of each column.
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公开(公告)号：US11891687B2
公开(公告)日：2024-02-06
申请号：US17038991
申请日：2020-09-30
申请人： Corning Incorporated , ICFO—The Institute of Photonic Sciences , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
发明人： Rinu Maniyara , Prantik Mazumder , Valerio Pruneri
CPC分类号： C23C14/5806 , C23C14/086 , C23C14/35 , H01B1/08
摘要： A method is provided for manufacturing an article comprising a transparent conductive material, wherein a transparent conductive material (e.g., indium tin oxide) is deposited onto a substrate (e.g., fused silica) by physical vapor deposition, then annealed at high temperature (i.e., at least 450° C.) in a nitrogen atmosphere. The resulting article comprises a transparent conductive material that reduces the trade-off between low resistivity (or sheet resistance) and high near infrared transmission. For example, the transparent conductive material thus obtained may possess a transmission of at least 80% at 1550 nm while having a resistivity of less than or equal to about 5×10−4 Ohm-cm and a Haacke figure of merit of at least about 40×10−4Ω−1. Also provided is a method for modulating the resistivity and/or the near infrared transmission of a transparent conductive material by annealing the transparent conductive material at a high temperature under nitrogen atmosphere.
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公开(公告)号：US20240016430A1
公开(公告)日：2024-01-18
申请号：US18037191
申请日：2021-11-16
发明人： Hendrik Anne SUPÈR
IPC分类号： A61B5/16
摘要： Methods are provided of measuring and improving attention of a person with first and second eyes. These methods include: displaying one or more stimuli aimed at attracting attention of the person; obtaining, through an eye tracker, positions of the first and second eyes over time; calculating, from the obtained positions of the first and second eyes, a gaze direction evolution for each of the eyes and corresponding angular velocity evolution for each of the gaze directions; determining a motion synchrony evolution of the first and second eyes by comparing the calculated angular velocity evolution of the first eye with the calculated angular velocity evolution of the second eye; and measuring the attention of the person depending on the determined motion synchrony evolution. Computer programs, systems and computer systems that are suitable to perform such methods of measuring and improving attention are also provided.
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公开(公告)号：US20240011982A9
公开(公告)日：2024-01-11
申请号：US17818802
申请日：2022-08-10
申请人： FUNDACIÓ DE RECERCA CLINIC BARCELONA-INSTITUTE D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER , Institució Catalana de Recerca i Estudis Avançats (ICREA)
发明人： Josep Dalmau , Lidia Sabater , Francesc Graus
IPC分类号： G01N33/564 , G01N33/68
CPC分类号： G01N33/564 , G01N33/6854
摘要： A method involves detecting in a sample an autoantibody binding specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. An autoantibody binds specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. A diagnostically useful carrier with a solid phase with an immobilized polypeptide contains one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2 or a variant thereof. The autoantibody can be used for diagnosing a neurological autoimmune disease or a cancer.
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7.发明授权公开(公告)号：US11710758B2
公开(公告)日：2023-07-25
申请号：US17311419
申请日：2019-12-09
IPC分类号： H01L27/146 , H04N25/77 , H04N25/531 , G01J1/44 , H04N25/63
CPC分类号： H01L27/14665 , H04N25/531 , H04N25/77
摘要： The present invention relates to an optoelectronic apparatus, comprising: —an optoelectronic device comprising: —a transport structure (T) comprising a 2-dimensional layer; —a photosensitizing structure (P) to absorb incident light and induce changes in the electrical conductivity of the transport structure (T); and—drain (D) and source (S) electrodes electrically connected to the transport structure (T); —a read-out unit to read an electrical signal, generated at a transport channel of the transport structure (T), after an integration time interval tint has passed, and during a taccess that is at least 10 times shorter than tint, wherein tint is longer than a predetermined trapping time τtr. The present invention also relates to a reading-out method, comprising performing the operations of the read-out unit of the apparatus of the invention, and to the use of the apparatus as a light detector or as an image sensor.
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公开(公告)号：US20230139885A1
公开(公告)日：2023-05-04
申请号：US17910564
申请日：2021-03-11
申请人： FUNDACIÓ INSTITUT DE RECERCA CONTRA LA LEUCÈMIA JOSEP CARRERAS , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) , UNIVERSITAT DE BARCELONA , FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS l PUJOL (IGTP) , ONECHAIN IMMUNOTHERAPEUTICS, S.L
发明人： Pablo MENÉNDEZ BUJÁN , Talía VELASCO HERNÁNDEZ , Samanta Romina ZANETTI , Pablo ENGEL ROCAMORA , Diego SÁNCHEZ MARTÍNEZ , Francisco GUTIERREZ AGÜERA , Adrián FERNÁNDEZ MARTÍN , Victor Manuel DÍAZ CORTÉS
IPC分类号： C07K16/28 , C12N5/0783 , A61P35/00
摘要： The present invention provides therapeutics for the treatment of CD22-positive cancers such as B-cell acute lymphoblastic leukemia (B-ALL). In particular, the present invention provides an anti-CD22 monoclonal antibody whose scFv as a part of chimeric antigen receptors (CAR) T-cells can target the first Ig extracellular domain of the CD22 antigen, the farthest domain from the membrane, for use in the treatment of CD22-positive cancers.
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9.发明授权公开(公告)号：US11631964B2
公开(公告)日：2023-04-18
申请号：US16761995
申请日：2017-11-06
摘要： A method for physical random number generation includes the steps of: modulating the gain of a vertical-cavity surface-emitting laser periodically from the lower threshold to the upper threshold and back; maintaining the gain per round trip positive for a longer period than the round trip time of the cavity; maintaining the net gain per round trip negative for a longer period than the round trip time of the cavity, in order to create optical pulses of random amplitude; detecting the optical pulses; converting the optical pulses into electrical analog pulses; and digitising the electrical analog pulses into random numbers.
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公开(公告)号：US11548811B2
公开(公告)日：2023-01-10
申请号：US17359739
申请日：2021-06-28
申请人： CORNING INCORPORATED , ICFO—The Institute of Photonic Science , Institució Catalana de Recerca i Estudis Avançats (ICREA)
发明人： Connie Li , Xinyuan Liu , Miriam Marchena Martín-Francés , Valerio Pruneri , Wageesha Senaratne , Zhen Song , Kamal Kishore Soni
IPC分类号： C03C17/22 , C01B32/186 , C01B32/182
摘要： Disclosed herein are graphene coatings characterized by a porous, three-dimensional, spherical structure having a hollow core, along with methods for forming such graphene coatings on glasses, glass-ceramics, ceramics, and crystalline materials. Such coatings can be further coated with organic or inorganic layers and are useful in chemical and electronic applications.
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