公开(公告)号：US20240208998A1

公开(公告)日：2024-06-27

申请号：US18556456

申请日：2022-04-21

申请人： FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÓGICA DE VALL HEBRON ,  UNIVERSITAT DE BARCELONA ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

发明人： Héctor GARCÍA PALMER ,  Isabel PUIG BORREIL ,  Josep TABERNERO CATURLA ,  Carlos GALDEANO CANTADOR ,  Diego MUÑOZ-TORRERO LÓPEZ-IBARRA ,  Xavier BARRIL ALONSO ,  Sergio RUIZ CARMONA

IPC分类号： C07D513/04 ,  A61K31/427 ,  A61K31/429 ,  A61P35/00 ,  C07D417/14 ,  C07D519/00

CPC分类号： C07D513/04 ,  A61K31/427 ,  A61K31/429 ,  A61P35/00 ,  C07D417/14 ,  C07D519/00

摘要： The present invention relates to 2-aminothiazol or 2-aminooxazol derivatives or pharmaceutically acceptable salt thereof for use in the treatment of hyperproliferative disorders, to method of treatment and/or prevention of hyperproliferative disorders using said compounds and to a subgroup of said derivatives which are new.

公开(公告)号：US20220190260A1

公开(公告)日：2022-06-16

申请号：US17199655

申请日：2021-03-12

申请人： Samsung Electronics Co., Ltd. ,  UNIVERSITAT DE BARCELONA

发明人： Yongsik JUNG ,  Laura RODRIGUEZ RAURELL ,  Joao Carlos LIMA ,  Hyeonho Choi ,  Seungyeon KWAK ,  Kyuyoung HWANG

IPC分类号： H01L51/00 ,  C07F1/00 ,  C09K11/06

摘要： An organometallic compound represented by Formula 1 wherein, M1 to M4 are each independently a first-row transition metal, a second-row transition metal, or a third-row transition metal; X1 and X2 are each independently C(R5)(R6), Si(R5)(R6), N(R5), O, S, Se, or Te; W1 to W4 are each independently N(R7)(R8), P(R7)(R8), S(R7), a C5-C60 carbocyclic group unsubstituted or substituted with at least one R10a, or a C1-C60 heterocyclic group unsubstituted or substituted with at least one R10a; L1 to L6 are each independently a C1-C30 alkylene group unsubstituted or substituted with at least one R10a, a C5-C60 carbocyclic group unsubstituted or substituted with at least one R10a, or a C1-C60 heterocyclic group unsubstituted or substituted with at least one R10a, a3 to a6 are each independently an integer from 0 to 3, and R1 to R8 and R10a in Formula 1 are as described herein.

公开(公告)号：US11363689B2

公开(公告)日：2022-06-14

申请号：US17266504

申请日：2019-07-31

申请人： Universitat de Barcelona ,  Enlighting Technologies S.L.

发明人： Adrià Huguet Ferran ,  Blas Garrido Fernández ,  Sergio Hernández Márquez

IPC分类号： H05B45/22 ,  H05B47/11 ,  H05B47/16

摘要： Method for generating light spectra and corresponding device. Starting from a plurality of light sources (2), comprising the steps of selecting a target colour from a target region (7) of a colour space, and emitting a target light (6) from said light sources (2) according to a weighted combination of light sources (2) corresponding to said target colour, using an output model (3) which is optimized according to an optimization parameter, and previously determined in a modelling stage comprising: —calculating a plurality of mixed spectra (4), as weighted combinations of said plurality of light sources (2), their colour coordinates and their optimization parameters; —partitioning in sectors a modelling region (5) of said colour space; —for each sector, selecting the mixed spectrum having the best optimization parameter; thus obtaining an optimized weighted combination; —using the optimized weighted combinations, establishing a correspondence between colours and weighted combinations; —thus obtaining said output model (3).

公开(公告)号：US20220143107A1

公开(公告)日：2022-05-12

申请号：US17602134

申请日：2020-04-14

申请人： INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS) ,  FUNDACIÓ CLÍNIC PER A LA RECERCA BIOMÈDICA ,  HOSPITAL CLÍNIC DE BARCELONA ,  UNIVERSITAT DE BARCELONA

发明人： Josep M. SUÑÉ NEGRE ,  Alex SORIANO VILADOMIU ,  Andrea AIRA GOMEZ ,  Csaba FEHER

IPC分类号： A61K35/741 ,  A61K9/48

摘要： The present invention provides a solid oral pharmaceutical composition comprising a pharmaceutically effective amount of living microorganisms and one or more pharmaceutically acceptable water absorbing excipient(s), wherein the composition has a water content, determined according to European Pharmacopoeia 9.4, section 2.5.12., from 0.5 to 30% with respect the total weight of the composition. The invention also provides processes for its preparation as well as it use in therapy. The live-cell based composition of the invention is stable at mild conditions.

公开(公告)号：US20220116555A1

公开(公告)日：2022-04-14

申请号：US17532589

申请日：2021-11-22

申请人： Universitat De Barcelona

发明人： David GASCÓN FORA ,  Sergio GÓMEZ FERNÁNDEZ ,  Joan MAURICIO FERRÉ

IPC分类号： H04N5/359 ,  H04N5/378

摘要： Silicon-based photomultipliers (SiPMs) for reducing optical crosstalk effects in the SiPMs are provided. The SiPMs include macrocells. Each macrocell includes microcells, coupled in parallel, and a reading circuit coupled to an output of each macrocell. The microcells are arranged in the SiPM so that adjacent microcells belong to different macrocells. When a microcell performs a detection, the reading circuit of each macrocell having one or more microcells adjacent to the microcell that performed the detection is configured to disable its output signal during a predefined period of time. PET devices or systems and methods for reducing crosstalk effects are also provided.

公开(公告)号：US11191851B2

公开(公告)日：2021-12-07

申请号：US16572260

申请日：2019-09-16

申请人： MUSC Foundation for Research Development ,  The United States Government as Represented by the Department of Veterans Affairs ,  The Regents of the University of Colorado, a body corporate ,  Universitat de Barcelona

发明人： Stephen Tomlinson ,  V. Michael Holers ,  Pablo Engel

IPC分类号： A61K49/00 ,  A61K51/10 ,  C07K16/18 ,  G01N33/569 ,  A61K49/16 ,  C07K16/28 ,  G01N33/534

摘要： Provided herein, inter alia, are compositions and methods of using the same for detecting complement activation.

公开(公告)号：US20200276138A1

公开(公告)日：2020-09-03

申请号：US16609124

申请日：2018-04-27

申请人： University of Virginia Patent Foundation ,  UNIVERSITAT DE BARCELONA ,  Consejo Superior de Investigaciones Cientificas

发明人： Thomas P. Loughran, JR. ,  Gemma Fabrias ,  Jose Luis Abad ,  Josefina Casas ,  David J. Feith ,  Su-Fern Tan ,  Jennifer M. Pearson ,  Antonio Delgado Cirilo

IPC分类号： A61K31/164 ,  A61P35/02

摘要： The present application provides novel compositions and methods for treating acute myeloid leukemia (AML). Compounds of the invention are acid ceramidase inhibitors, reduce AML cell viability, inhibit AML cell proliferation, increase cell death of AML cells, and induce apoptosis in AML cells. A primary compound of the invention is SACLAC: 2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide. The bromine analog of SACLAC (SABRAC: 2-bromo-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide) is also useful for treating AML. SACLAC has much better activity than other know drugs used to treat AML.

公开(公告)号：US20190084927A1

公开(公告)日：2019-03-21

申请号：US16142907

申请日：2018-09-26

申请人： UNIVERSITAT DE BARCELONA ,  FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) ,  IPROTEOS S.L.

发明人： Ernest Giralt Lledó ,  Teresa Tarragó Clua ,  Roger Prades Cosano ,  Soledad Royo Gracia

IPC分类号： C07D207/16 ,  C07D403/06

摘要： The present invention relates to 1-[1-(benzoyl )-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity formula (I) to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.

公开(公告)号：US20180313688A1

公开(公告)日：2018-11-01

申请号：US15768084

申请日：2016-10-20

申请人： UNIVERSITAT DE BARCELONA

发明人： Angel DIEGUEZ BARRIENTOS ,  Oscar ALONSO CASANOVAS ,  Joan CANALS GIL ,  Eva VILELLA FIGUERAS

IPC分类号： G01J1/02 ,  G01J1/46

CPC分类号： G01J1/0238 ,  G01J1/46 ,  G01J2001/442 ,  G01J2001/4466 ,  H03K5/1534 ,  H03K5/19

摘要： Signal processing method for histogram generation, and corresponding device and use. The method generates the histogram from a plurality of event detectors that generate event signals as a response to external events, and are connected to a current injection module which is connected to a plurality of capacitors, wherein each histogram bin is univocally assigned to a capacitor. The method includes: during an event time interval corresponding to a bin, the event detectors generate event signals as a response to external events; the current injection module detects said event signals and, for each event signal, generates a corresponding current signal, which is injected in a capacitor assigned to said bin, and stored therein; repeating steps for each successive bin of said histogram; and reading the charge accumulated in each of said capacitors.

公开(公告)号：US20180154106A1

公开(公告)日：2018-06-07

申请号：US15883692

申请日：2018-01-30

申请人： UNIVERSITAT DE BARCELONA ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ,  INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)

发明人： Mavi SÁNCHEZ VIVES ,  Mel SLATER ,  Jorge ARROYO PALACIOS

IPC分类号： A61M21/02

CPC分类号： A61M21/02 ,  A61B5/1114 ,  A61B5/16 ,  A61B5/6814 ,  A61B5/744 ,  A61M2021/0027 ,  A61M2021/005 ,  A61M2205/50 ,  A61M2205/582 ,  A61M2209/088 ,  A61M2230/06 ,  A61M2230/42 ,  A61M2230/50 ,  A61M2230/63 ,  A61M2230/65 ,  G06F3/012 ,  G06F3/016 ,  G06T13/40

摘要： Methods for provoking a physiological response in a subject comprising: receiving from sensors an orientation of an HMD of the subject and a parameter indicative of a physiological state of the subject, determining a video signal representing an avatar of the subject in a virtual reality scenario to be displayed on the head mounted display taking into account the orientation of the head mounted display, wherein the video signal includes an indication of a physiological state of the avatar, and sending the video signal to the head mounted display for visualization, optionally accompanied by a suitable audio signal. During a first period, the indication of the physiological state of the avatar substantially corresponds to the measured physiological state, and during a second period the indication of the physiological state of the avatar does not correspond to the measured physiological state. Related computer program and computing systems are also disclosed.