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    SILENCER DEVICE
    1.
    发明申请
    SILENCER DEVICE 审中-公开
    沉默器

    公开(公告)号：US20160238335A1

    公开(公告)日：2016-08-18

    申请号：US15040845

    申请日：2016-02-10

    Applicant: Werner Bertschinger ,  Hugo Ziegler

    Inventor： Werner Bertschinger ,  Hugo Ziegler

    IPC: F41A21/30

    CPC classification number: F41A21/30

    Abstract: A silencer device for a firearm has a center portion including at least two substantially semi-circular chamber partition wall elements being spaced from one another in the longitudinal direction of the center portion, a housing portion into which the center portion is introduced, wherein between the at least two substantially semi-circular chamber partition wall elements and the inner wall of the housing portion at least one chamber is formed; and a positioning portion being at least connectable to the housing portion. The at least two substantially semi-circular chamber partition wall elements respectively comprise on their outer sides at least one chamfer, which form a lateral passage for explosive gases with the inner wall of the housing portion.

    Abstract translation: 用于枪支的消音装置具有中心部分，该中心部分包​​括沿中心部分的纵向方向彼此间隔开的至少两个基本上半圆形的室隔壁元件，其中引入中心部分的壳体部分， 至少两个大致半圆形的室隔壁元件和壳体部分的内壁形成至少一个室; 并且至少可连接到所述壳体部分的定位部分。 所述至少两个基本上为半圆形的室隔壁元件在其外侧分别包括至少一个倒角，其形成用于爆炸性气体的外部通道与壳体部分的内壁。

    COSMETIC COMPOSITION FOR STIMULATING THE SYNTHESIS OF PROTEINS OF THE BASEMENT MEMBRANE
    2.
    发明申请
    COSMETIC COMPOSITION FOR STIMULATING THE SYNTHESIS OF PROTEINS OF THE BASEMENT MEMBRANE 有权
    用于刺激基底膜蛋白质合成的化妆品组合物

    公开(公告)号：US20130012686A1

    公开(公告)日：2013-01-10

    申请号：US13614337

    申请日：2012-09-13

    Applicant: Hugo ZIEGLER ,  Dominik IMFELD ,  Martin STOCKLI ,  Marc HEIDL

    Inventor： Hugo ZIEGLER ,  Dominik IMFELD ,  Martin STOCKLI ,  Marc HEIDL

    IPC: C07K5/11 ,  C07K5/09

    CPC classification number: A61Q19/08 ,  A61K8/64 ,  C07K5/0815 ,  C07K5/1019

    Abstract: Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or ary1-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

    Abstract translation: 可以局部应用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20烷基，环烷基或芳基，C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

    Method for producing 3-amidinophenylalanine derivatives
    3.
    发明授权
    Method for producing 3-amidinophenylalanine derivatives 有权
    制备3-脒基苯丙氨酸衍生物的方法

    公开(公告)号：US08088921B2

    公开(公告)日：2012-01-03

    申请号：US12905769

    申请日：2010-10-15

    Applicant: Hugo Ziegler ,  Peter Wikstroem

    Inventor： Hugo Ziegler ,  Peter Wikstroem

    IPC: C07D295/00 ,  C07D213/00

    CPC classification number: C07D295/205 ,  C07D211/60

    Abstract: The present invention describes a method for the synthesis of enantiomerically pure 3-amidinophenylalanine derivatives, which are used as pharmaceutically effective urokinase inhibitors, by starting from 3-cyanophenylalanine derivatives. The methods of manufacture comprising only one synthesis step lead to new intermediates, namely 3-hydroxyamidino- and 3-amidrazonophenylalanine derivatives. These intermediates or their acetyl derivatives can be reduced into the desired 3-amidino-phenylalanine derivatives under gentle conditions (H2 or ammonium formiate, Pd/C (approx. 10%), ethanol/water, room temperature, normal pressure or also H2, Pd/C, AcOH or HCl/ethanol, 1-3 bar) in excellent yields and in an enantiomeric excess of up to 99.9%.

    Abstract translation: 本发明描述了通过从3-氰基苯丙氨酸衍生物开始合成用作药物有效的尿激酶抑制剂的对映体纯的3-脒基苯丙氨酸衍生物的方法。 仅包含一个合成步骤的制备方法导致新的中间体，即3-羟基脒基 - 和3-酰胺基苯丙氨酸衍生物。 这些中间体或其乙酰基衍生物可以在温和的条件下（H2或甲酸铵，Pd / C（约10％），乙醇/水，室温，常压或还有H2），还原成所需的3-脒基 - 苯丙氨酸衍生物， Pd / C，AcOH或HCl /乙醇，1-3巴），产率高达99.9％，对映异构体过量。

    TRIPEPTIDES AND DERIVATIVES THEREOF FOR COSMETIC APPLICATION IN ORDER TO IMPROVE SKIN STRUCTURE
    4.
    发明申请
    TRIPEPTIDES AND DERIVATIVES THEREOF FOR COSMETIC APPLICATION IN ORDER TO IMPROVE SKIN STRUCTURE 有权
    用于化妆品应用的TRIPEPTIDES及其衍生物以改善皮肤结构

    公开(公告)号：US20110142895A1

    公开(公告)日：2011-06-16

    申请号：US12954142

    申请日：2010-11-24

    Applicant: Hugo Ziegler ,  Marc Heidl ,  Dominik Imfeld

    Inventor： Hugo Ziegler ,  Marc Heidl ,  Dominik Imfeld

    IPC: A61K8/64 ,  A61Q19/08 ,  A61K38/06 ,  A61Q19/04 ,  A61P17/10 ,  A61P17/18 ,  A61P29/00 ,  A61Q19/06 ,  A61P31/00 ,  A61P17/00 ,  A61Q17/04 ,  A61K8/02 ,  B82Y5/00

    CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q19/08

    Abstract: The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

    Abstract translation: 本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。 本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

    Substrates for TAFI (A)
    5.
    发明授权
    Substrates for TAFI (A) 有权
    TAFI基板（A）

    公开(公告)号：US07718406B2

    公开(公告)日：2010-05-18

    申请号：US10530165

    申请日：2002-12-06

    Applicant: Hugo Ziegler ,  Dagmar Prasa ,  Jörg Stürzebecher ,  Peter Wikstroem

    Inventor： Hugo Ziegler ,  Dagmar Prasa ,  Jörg Stürzebecher ,  Peter Wikstroem

    IPC: C12P13/04 ,  A61K38/00

    CPC classification number: C07K5/06095 ,  C07K5/06086 ,  C07K5/06147 ,  C07K5/08 ,  C07K5/0802 ,  C12Q1/56

    Abstract: The invention relates to compounds of general formula (I) and acid addition salts thereof, where the various symbols have the meanings given in the description and claims, the production and use thereof as substrate for the detection of TAFIa, a fibrinolysis inhibiting enzyme. The detection occurs by using the absorption between 400 and 412 nm, arising as a result of the formation of 3-carboxy-4-nitrothiophenol from Ellman's reagent as a function of time.

    Abstract translation: 本发明涉及通式（I）的化合物及其酸加成盐，其中各种符号具有在说明书和权利要求书中给出的含义，其作为检测TAFIa，纤维蛋白溶解抑制酶的底物的生产和用途。 通过使用400和412nm之间的吸收作为由Ellman试剂形成3-羧基-4-硝基苯硫酚作为时间的函数而产生的检测发生。

    Microbiocidal N-phenyl-N-[4-(4-pyridyl-2-pyrimidin-2-yl]-amine derivatives
    7.
    发明授权
    Microbiocidal N-phenyl-N-[4-(4-pyridyl-2-pyrimidin-2-yl]-amine derivatives 失效

    公开(公告)号：US07074787B2

    公开(公告)日：2006-07-11

    申请号：US10451930

    申请日：2001-12-20

    Applicant: Martin Eberle ,  Hugo Ziegler ,  Fredrik Cederbaum ,  Peter Ackermann ,  Anita Schnyder

    Inventor： Martin Eberle ,  Hugo Ziegler ,  Fredrik Cederbaum ,  Peter Ackermann ,  Anita Schnyder

    IPC: C07D401/04 ,  C07D413/04 ,  A01N43/54

    CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14

    Abstract: The invention relates to novel N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives of the general formula (I) wherein the sum of (m+p) together is 0, 1, 2 or 3; n and q are independently of each other 0 or 1, and the sum of (m+p+q) together is 1, 2, 3 or 4; R1 is hydrogen, halogen, alkoxy, haloalkyl, haloalkoxy or alkyl; R2 is hydrogen, C1–C6-alkyl, C1–C6-haloalkyl or C1–C6-alkoxy; R2A is hydrogen, C1–C6-alkyl, C3–C4-alkenyl or C3–C4-alkynyl; each of R3, R4, R5 and R6 is, independently of the others, hydrogen, C1–C6-alkyl, C1–C6-haloalkyl, hydroxy-C1–C6-alkyl or C1–C6-alkoxy-C1–C6-alkyl, or the ring members CR3R4 or CR5R6 or CR2R2A are independently of each other a carbonyl group (C═O) or a group C═S; X is C═O, C═S, S═O or O═S═O; Y is O, S, C═O, CH2, —N(R8)—, —O—N(R8)—, —N(R8)—O— or NH—; R7 is hydrogen, C1–C4-alkyl, C3–C4-alkenyl, C3–C4-alkynyl, —CH2OR8, CH2SR8, —C(O)R8, —C(O)OR8, SO2R8, SOR8 or SR8; and R8 is C1–C8-alkyl, C1–C8-alkoxyalkyl, C1–C8 haloalkyl or phenylC1–C2-alkyl wherein the phenyl may be substituted by up to three groups selected from halo or C1–C4-alkyl; or a salt thereof. The invention also relates to the preparation of the compounds and to agrochemical compositions comprising at least one of those compounds as active ingredient as well as the preparation of the said compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

    Pesticidal bis-oxime compounds
    8.
    发明授权
    Pesticidal bis-oxime compounds 失效
    杀虫双肟化合物

    公开(公告)号：US06525092B1

    公开(公告)日：2003-02-25

    申请号：US09787481

    申请日：2001-04-27

    Applicant: Hugo Ziegler ,  Stephan Trah

    Inventor： Hugo Ziegler ,  Stephan Trah

    IPC: A01N3734

    CPC classification number: C07C251/48 ,  A01N37/50 ,  C07C251/60 ,  C07C255/61

    Abstract: Bis-oxime compounds of the general formula (I) are provided wherein X, Y, R1, R2 R3 and n are as defined in the specification. The bis-oxime compounds possess pesticidal activity, which may provide plants with protection from phytopathogenic microorganisms.

    Abstract translation: 提供通式（I）的双肟化合物，其中X，Y，R 1，R 2，R 3和n如说明书中所定义。 双肟化合物具有杀虫活性，可为植物提供植物病原微生物的保护。

    Silencer device
    10.
    发明授权
    Silencer device 有权

    公开(公告)号：US10094633B2

    公开(公告)日：2018-10-09

    申请号：US15040845

    申请日：2016-02-10

    Applicant: Werner Bertschinger ,  Hugo Ziegler

    Inventor： Werner Bertschinger ,  Hugo Ziegler

    IPC: F41A21/30

    Abstract: A silencer device for a firearm has a center portion including at least two substantially semi-circular chamber partition wall elements being spaced from one another in the longitudinal direction of the center portion, a housing portion into which the center portion is introduced, wherein between the at least two substantially semi-circular chamber partition wall elements and the inner wall of the housing portion at least one chamber is formed; and a positioning portion being at least connectable to the housing portion. The at least two substantially semi-circular chamber partition wall elements respectively comprise on their outer sides at least one chamfer, which form a lateral passage for explosive gases with the inner wall of the housing portion.

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