公开(公告)号：US07863417B2

公开(公告)日：2011-01-04

申请号：US10555994

申请日：2004-05-07

Applicant: Hugo Ziegler ,  Marc Heidl ,  Dominik Imfeld

Inventor： Hugo Ziegler ,  Marc Heidl ,  Dominik Imfeld

IPC: C07K5/08

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q19/08

Abstract: The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or —NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

Abstract translation: 本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或-NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。 本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

公开(公告)号：US20090155347A1

公开(公告)日：2009-06-18

申请号：US12226191

申请日：2006-04-28

Applicant: Hugo Ziegler ,  Dominik Imfeld ,  Martin Stockli ,  Marc Heidl

Inventor： Hugo Ziegler ,  Dominik Imfeld ,  Martin Stockli ,  Marc Heidl

IPC: A61K9/127 ,  C07K5/09 ,  A61K38/06

CPC classification number: A61Q19/08 ,  A61K8/64 ,  C07K5/0815 ,  C07K5/1019

Abstract: Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

Abstract translation: 可以局部施用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20 - 烷基，环烷基或芳基-C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

公开(公告)号：US20070099842A1

公开(公告)日：2007-05-03

申请号：US10555994

申请日：2004-05-07

Applicant: Hugo Ziegler ,  Marc Heldi ,  Dominik Imfeld

Inventor： Hugo Ziegler ,  Marc Heldi ,  Dominik Imfeld

IPC: A61K38/05 ,  C07K5/08

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q19/08

Abstract: The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or —NH—; or XR5 with X=O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

Abstract translation: 本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6 O >，-SO 2 -OR 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2 - ）N - 2或（CH 2 2）3 -NHC（NH）NH 2; n等于1 4; R 3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选被取代的（C 1 -C 24 - ）烷基，任选取代的C 2 -C 24链烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4 - 烷基或9-芴基 - 甲基; X表示氧（-O-）或-NH-; 或XR 5，X = O也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R 1和R 5， 不表示氢，X不同时代表氧。 本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

公开(公告)号：US08722852B2

公开(公告)日：2014-05-13

申请号：US13614337

申请日：2012-09-13

Applicant: Hugo Ziegler ,  Dominik Imfeld ,  Martin Stockli ,  Marc Heidl

Inventor： Hugo Ziegler ,  Dominik Imfeld ,  Martin Stockli ,  Marc Heidl

IPC: C07K5/11

CPC classification number: A61Q19/08 ,  A61K8/64 ,  C07K5/0815 ,  C07K5/1019

Abstract: Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

Abstract translation: 可以局部施用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20 - 烷基，环烷基或芳基-C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

公开(公告)号：US20120094919A1

公开(公告)日：2012-04-19

申请号：US13254564

申请日：2010-03-16

Applicant: Remo Gräub ,  Marc Heidl ,  Dominik Imfeld ,  Eike Müller ,  Peter Wikstroem ,  Hugo Ziegler

Inventor： Remo Gräub ,  Marc Heidl ,  Dominik Imfeld ,  Eike Müller ,  Peter Wikstroem ,  Hugo Ziegler

IPC: A61K8/64 ,  A61Q19/00

CPC classification number: A61K8/64 ,  A61K38/06 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  A61Q19/10

Abstract: The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.

Abstract translation: 本发明涉及三肽衍生物用于紧固，固紧和/或保湿皮肤的用途。 此外，本发明涉及用于刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基和/或蛋白聚糖的成纤维细胞和/或角质形成细胞的糖胺聚糖的合成的方法，所述方法尤其是合成透明质酸和 /或蛋白聚糖Decorin和/或Lumican。

公开(公告)号：US20110086060A1

公开(公告)日：2011-04-14

申请号：US12933961

申请日：2009-04-08

Applicant: Florence Bidamant ,  Dominik Imfeld ,  Peter Joller ,  Heidi Moser

Inventor： Florence Bidamant ,  Dominik Imfeld ,  Peter Joller ,  Heidi Moser

IPC: A61K8/97 ,  A61K36/00 ,  A61K36/28 ,  A61K36/53 ,  A61K36/23 ,  A61K8/99 ,  A61Q19/00 ,  A61P29/00 ,  A61P17/02

CPC classification number: A61K36/28 ,  A61K31/164 ,  A61K36/185 ,  A61K36/23 ,  A61K36/53 ,  A61K38/06 ,  A61K38/08

Abstract: The present invention relates to a composition comprising panthenol, a collagen synthesis stimulating peptide and an anti-inflammatory extract. The compositions are particular useful for preventing and treating stretch marks.

Abstract translation: 本发明涉及包含泛醇，胶原合成刺激肽和抗炎提取物的组合物。 组合物特别用于预防和治疗妊娠纹。

公开(公告)号：US08420778B2

公开(公告)日：2013-04-16

申请号：US12954142

申请日：2010-11-24

Applicant: Hugo Ziegler ,  Marc Heidl ,  Dominik Imfeld

Inventor： Hugo Ziegler ,  Marc Heidl ,  Dominik Imfeld

IPC: C07K5/08

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q19/08

Abstract: The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

Abstract translation: 本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。 本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

公开(公告)号：US08293712B2

公开(公告)日：2012-10-23

申请号：US12226191

申请日：2006-04-28

Applicant: Hugo Ziegler ,  Dominik Imfeld ,  Martin Stöckli ,  Marc Heidl

Inventor： Hugo Ziegler ,  Dominik Imfeld ,  Martin Stöckli ,  Marc Heidl

IPC: A61K38/39 ,  A61K38/00 ,  A61K31/74

CPC classification number: A61Q19/08 ,  A61K8/64 ,  C07K5/0815 ,  C07K5/1019

Abstract: Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

Abstract translation: 可以局部施用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20 - 烷基，环烷基或芳基-C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

公开(公告)号：US20140044656A1

公开(公告)日：2014-02-13

申请号：US14000747

申请日：2012-02-28

Applicant: Regina Goralczyk ,  Remo Gräub ,  Dominik Imfeld ,  Jürgen H. Vollhardt

Inventor： Regina Goralczyk ,  Remo Gräub ,  Dominik Imfeld ,  Jürgen H. Vollhardt

IPC: A61K8/365 ,  A61Q17/04

CPC classification number: A61K8/365 ,  A61K8/046 ,  A61K8/602 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/04 ,  A61Q19/08

Abstract: The present invention relates to the use of steviol as well as derivatives thereof as a skin tanning agent. Furthermore, the present invention relates to the cosmetic topical application of steviol and derivatives thereof formulated into a composition comprising a cosmetically acceptable carrier for skin tanning. Finally, the invention relates to the use of steviol for enhancement of melanin formation in human skin cells.

Abstract translation: 本发明涉及甜菊醇及其衍生物作为皮肤鞣剂的用途。 此外，本发明涉及配制成包含化妆品可接受的皮肤晒黑载体的组合物的甜菊醇及其衍生物的美容局部施用。 最后，本发明涉及甜菊醇用于增强人皮肤细胞中黑色素形成的用途。

公开(公告)号：US20130012686A1

公开(公告)日：2013-01-10

申请号：US13614337

申请日：2012-09-13

Applicant: Hugo ZIEGLER ,  Dominik IMFELD ,  Martin STOCKLI ,  Marc HEIDL

Inventor： Hugo ZIEGLER ,  Dominik IMFELD ,  Martin STOCKLI ,  Marc HEIDL

IPC: C07K5/11 ,  C07K5/09

CPC classification number: A61Q19/08 ,  A61K8/64 ,  C07K5/0815 ,  C07K5/1019

Abstract: Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or ary1-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

Abstract translation: 可以局部应用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20烷基，环烷基或芳基，C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。