公开(公告)号：USRE42890E1

公开(公告)日：2011-11-01

申请号：US12796135

申请日：2004-05-19

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

IPC: A61K31/4245 ,  C07D413/04

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R1 to R6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为氧，羰基，羰基肟衍生物或α，β-不饱和羰基，取代基R 1至R 6具有 本说明书中用作药物的含义，式（I）的新型化合物，合成这些化合物的方法，含有式（I）化合物的药物组合物，使用式（I）化合物 ）用于制备用于治疗肿瘤和自身免疫疾病的药物组合物，以及使用这样的式（I）化合物或含有其的药物组合物治疗肿瘤和自身免疫性疾病的方法

公开(公告)号：US20080251635A1

公开(公告)日：2008-10-16

申请号：US12037599

申请日：2008-02-26

Applicant: Martin Eberle ,  Tim Rabel

Inventor： Martin Eberle ,  Tim Rabel

IPC: B64B1/00

CPC classification number: B64F1/14 ,  B64B1/58 ,  B64B1/66

Abstract: An apparatus for launching and recovering a lighter-than-air aircraft is provided. The aircraft includes an envelope that is substantially filled before launch with a lift gas and a second gas. The lift gas and second gas are substantially separated in the envelope by a boundary layer of mixed gas, formed by the lift and second gases. The aircraft is supported by one or more masts as the lift gas is injected to achieve the required buoyancy for launch. The aircraft is then released and rises, for example, in an inclined orientation. As the aircraft climbs, the lift gas expands in the envelope, and the second gas is vented therefrom. During horizontal descent, air can be pumped into the envelope to maintain the envelope in a substantially filled configuration. The air and lift gas can be mixed to avoid sloshing and pooling.

Abstract translation: 提供了一种用于发射和恢复轻型飞机的装置。 该飞机包括一个信封，其在发射之前用提升气体和第二个气体基本上被填充。 提升气体和第二气体通过由升力和第二气体形成的混合气体的边界层在壳体中基本分离。 飞机由一个或多个桅杆支撑，因为提升气体被注入以实现所需的浮力用于发射。 然后飞机被释放并且例如以倾斜的方向上升。 当飞机爬升时，提升气体在信封中膨胀，并且第二气体从其中排出。 在水平下降期间，可以将空气泵送到信封中，以将信封保持在基本上充满的配置。 空气和提升气体可以混合，以避免晃动和汇集。

公开(公告)号：US07423157B2

公开(公告)日：2008-09-09

申请号：US11501648

申请日：2006-08-09

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

IPC: C07D403/04

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为键，羰基，羰基，亚乙基或亚乙基羰基的衍生物，R 1， 任选取代的氨基或羟基，并且取代基R 2至R 6具有本说明书中给出的含义，这些化合物的合成方法，含有化合物的药物组合物 的式（I）化合物的中间体，用于将式（I）化合物用作药物并用于制备用于治疗肿瘤和自身免疫性疾病的药物组合物的用途，以及治疗肿瘤和自身免疫性疾病的方法 使用式（I）化合物或含有其的药物组合物。

公开(公告)号：US07380750B2

公开(公告)日：2008-06-03

申请号：US11279901

申请日：2006-04-17

Applicant: Martin Eberle ,  Tim Rabel

Inventor： Martin Eberle ,  Tim Rabel

IPC: B64B1/00

CPC classification number: B64F1/14 ,  B64B1/58 ,  B64B1/66

Abstract: An apparatus and associated method for launching and recovering a lighter-than-air aircraft are provided. The aircraft includes an envelope that is substantially filled before launch with a lift gas and a second gas. The lift gas and second gas are substantially separated in the envelope by a boundary layer of mixed gas, formed by the lift and second gases. The aircraft is supported by one or more masts as the lift gas is injected to achieve the required buoyancy for launch. The aircraft is then released and rises, for example, in an inclined orientation. As the aircraft climbs, the lift gas expands in the envelope, and the second gas is vented therefrom. During horizontal descent, air can be pumped into the envelope to maintain the envelope in a substantially filled configuration. The air and lift gas can be mixed to avoid sloshing and pooling.

Abstract translation: 提供了一种用于发射和恢复轻型飞机的装置和相关方法。 该飞机包括一个信封，其在发射之前用提升气体和第二个气体基本上被填充。 提升气体和第二气体通过由升力和第二气体形成的混合气体的边界层在壳体中基本分离。 飞机由一个或多个桅杆支撑，因为提升气体被注入以实现所需的浮力用于发射。 然后飞机被释放并且例如以倾斜的方向上升。 当飞机爬升时，提升气体在信封中膨胀，并且第二气体从其中排出。 在水平下降期间，可以将空气泵送到信封中，以将信封保持在基本上充满的配置。 空气和提升气体可以混合，以避免晃动和汇集。

公开(公告)号：US20060205739A1

公开(公告)日：2006-09-14

申请号：US11433511

申请日：2006-05-12

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Goutam Saha ,  Subir Sadhukhan ,  Rohit Saxena ,  Sudhir Srivastava

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Goutam Saha ,  Subir Sadhukhan ,  Rohit Saxena ,  Sudhir Srivastava

IPC: A61K31/506 ,  C07D403/02

CPC classification number: C07D213/85

Abstract: The invention relates to novel substituted 2-(phenyl-, pyridyl- or pyrimidyl-carbonyl)-furanes and -thiophenes and related phenoxy/phenylthio-acetophenones and corresponding heterocyclic compounds, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such a diseases.

公开(公告)号：US06686469B2

公开(公告)日：2004-02-03

申请号：US10011012

申请日：2001-11-05

Applicant: Martin Eberle ,  André Jeanguenat ,  Werner Zambach ,  Arthur Steiger ,  Saleem Farooq

Inventor： Martin Eberle ,  André Jeanguenat ,  Werner Zambach ,  Arthur Steiger ,  Saleem Farooq

IPC: C07D2412

CPC classification number: C07D239/26 ,  A01N43/54 ,  C07D239/28 ,  C07D239/34 ,  C07D239/36 ,  C07D239/42 ,  C07D239/54

Abstract: The invention relates to compounds of the general formula wherein R1 is unsubstituted or mono- to penta-substituted aryl, whereby the substituents are selected from the group consisting for instance of OH, Halogen, CN, C1-C6-alkyl, optionally substituted C3-C8-cycloalkyl and optionally substituted C3-C8-cycloalkenyl; A is for instance a single bond, C1-C12-alkylene or O; X1 and X2, independently of one another, are R10; X3 is H or R10; R10 is for instance halogen, CN, NO2, C1-C6-alkyl, C3-C8-cycloalkyl or C1-C6-haloalkyl; R21 and R22, independently of one another are for instance H, halogen, CN, NO2, OH, SH, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C6-alkyl-C3-C8-cycloalkyl or C3-C8-cycloalkyl-C1-C6-alkyl; R23 and R24, independently of one another, are for instance H, C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C6-alkyl, C1-C6-haloalkyl or C3-C8-halocycloalkyl; m is 1, 2, 3 or 4; and n is 0, 1 or 2; as well as the physiologically acceptable addition compounds, a method of producing these compounds and the usage of these compounds, pesticide compositions whose active ingredient is chosen from these compounds, each in free form or in agrochemically employable salt form, and a method of producing and using these compositions. The active ingredients, in free form or in agrochemically employable salt form, have advantageous pesticidal properties. The are especially suitable for the control of pests in agriculture and in storage, as well as in the care of domestic animals.

Abstract translation: 本发明涉及通式为化学式R 1的化合物是未取代的或一至五取代的芳基，其中取代基选自例如OH，卤素，CN，C 1 -C 6 - 烷基，任选取代的C 3 -C 8 - 环烷基和任选取代的C 3 -C 8 - 环烯基; A为例如单键，C 1 -C 12 - 亚烷基或O; X 1和X 2彼此独立地为R 10; X3为H或R10; R10为卤素，CN，NO2，C1-C6-烷基，C3-C8-环烷基或C1-C6-卤代烷基; R21和R22彼此独立地为例如H，卤素，CN ，NO 2，OH，SH，C 1 -C 6烷基，C 3 -C 8 - 环烷基，C 1 -C 6烷基-C 3 -C 8 - 环烷基或C 3 -C 8环烷基-C 1 -C 6烷基; R 23和R 24独立地为 另一个例子是H，C 1 -C 6烷基，C 3 -C 8环烷基，C 3 -C 8环烷基-C 1 -C 6烷基，C 1 -C 6卤代烷基或C 3 -C 8卤代环烷基; m是1,2,3 或4; 和n为0,1或2;以及生理上可接受的加成化合物，这些化合物的制备方法和这些化合物的用途，其活性成分选自这些化合物的农药组合物，各自为游离形式或农业化学可使用的盐 形式，以及生产和使用这些组合物的方法。 活性成分，游离形式或具有农业化学应用的盐形式，具有有利的杀虫特性。 特别适用于农业，仓储以及家畜照顾中的害虫控制。

公开(公告)号：US06365620B2

公开(公告)日：2002-04-02

申请号：US09780897

申请日：2001-02-09

Applicant: Martin Eberle ,  Harald Walter

Inventor： Martin Eberle ,  Harald Walter

IPC: C07D20740

CPC classification number: C07D207/416 ,  C07D409/12 ,  C07D409/14

Abstract: The invention relates to pesticidal trifluoromethylpyrrolcarboxamides of formula I wherein R1 is hydrogen, halogen, C1-4haloalkyl or C1-4alkyl, R2 is C1-4alkyl, C1-4haloalkyl, C1-4alkoxy-C1-4alkyl, cyano, C1-4alkylsulfonyl, phenylsulfonyl, di(C1-4alkyl)aminosulfonyl, C1-6alkylcarbonyl, benzoyl, or substituted phenylsulfonyl or benzoyl, and A is a group wherein R3 is C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6haloalkenyl, C2-6alkinyl, C1-6alkoxy, C1-6haloalkoxy, C2-6alkenyloxy, C2-6haloalkenyloxy, C2-6alkinyloxy, C3-7cycloalkyl, C1-4alkyl-C3-7cycloalkyl, C4-7cycloalkenyl, C1-4alkyl-C4-7cycloalkenyl, C3-7cycloalkyloxy, C1-4alkyl-C3-7cycloalkyloxy, C5-7cycloalkenyloxy, C1-4alkyl-C5-7cycloalkenyloxy, phenyl, naphthyl, phenoxy, naphthyloxy, or substituted phenyl or phenoxy wherein the substitutents are one to three groups independently selected from halogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, cyano, C1-4alkoxycarbonyl, C1-4alkylcarbonyl, C1-4haloalkyl, C1-4haloalkoxy, methylenedioxy or difluoromethylenedioxy, or phenyl; R4 is hydrogen, halogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy or C1-4haloalkoxy; and R5, R6 and R7 independently of each other are C1-6alkyl, C3-7cycloalkyl or C3-7cycloalkyl-C2-14alkyl. The compounds have plant-protecting properties and are suitable for protecting plants against infestation by phytopathogenic microorganisms.

Abstract translation: 本发明涉及式I的杀虫三氟甲基吡咯甲酰胺，其中R 1是氢，卤素，C 1-4卤代烷基或C 1-4烷基，R 2是C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基-C 1-4烷基，氰基，C 1-4烷基磺酰基，苯基磺酰基，二 C 1-4烷基）氨基磺酰基，C 1-6烷基羰基，苯甲酰基或取代的苯基磺酰基或苯甲酰基，A是其中R 3是C 1-6烷基，C 1-6卤代烷基，C 2-6烯基，C 2-6卤代烯基，C 2-6炔基，C 1-6烷氧基，C 1-6卤代烷氧基 ，C 2-6烯基氧基，C 2-6炔氧基，C 2-6烷氧基，C 3-7环烷基，C 1-4烷基-C 3-7环烷基，C 4-7环烯基，C 1-4烷基-C 4-7环烯基，C 3-7环烷氧基，C 1-4烷基-C 3-7环烷氧基，C 5 7-环烯氧基，C 1-4烷基-C 5-7环烯基氧基，苯基，萘基，苯氧基，萘氧基或取代的苯基或苯氧基，其中取代基是独立地选自卤素，C 1-4烷基，C 1-4烷氧基，C 1-4烷硫基，氰基 ，C 1-4烷氧基羰基，C 1-4烷基羰基，C 1-4卤代烷基，C 1-4卤代烷氧基，亚甲二氧基或二氟 亚甲二氧基或苯基; R 4是氢，卤素，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基或C 1-4卤代烷氧基; R 5，R 6和R 7彼此独立地为C 1-6烷基，C 3-7环烷基或C 3-7环烷基-C 21-14烷基。化合物具有植物保护性质，并且适用于保护植物免受植物病原微生物侵扰。

公开(公告)号：US20060169836A1

公开(公告)日：2006-08-03

申请号：US11279901

申请日：2006-04-17

Applicant: Martin Eberle ,  Tim Rabel

Inventor： Martin Eberle ,  Tim Rabel

IPC: B64B1/06

CPC classification number: B64F1/14 ,  B64B1/58 ,  B64B1/66

Abstract: An apparatus and associated method for launching and recovering a lighter-than-air aircraft are provided. The aircraft includes an envelope that is substantially filled before launch with a lift gas and a second gas. The lift gas and second gas are substantially separated in the envelope by a boundary layer of mixed gas, formed by the lift and second gases. The aircraft is supported by one or more masts as the lift gas is injected to achieve the required buoyancy for launch. The aircraft is then released and rises, for example, in an inclined orientation. As the aircraft climbs, the lift gas expands in the envelope, and the second gas is vented therefrom. During horizontal descent, air can be pumped into the envelope to maintain the envelope in a substantially filled configuration. The air and lift gas can be mixed to avoid sloshing and pooling.

Abstract translation: 提供了一种用于发射和恢复轻型飞机的装置和相关方法。 该飞机包括一个信封，其在发射之前用提升气体和第二个气体基本上被填充。 提升气体和第二气体通过由升力和第二气体形成的混合气体的边界层在壳体中基本分离。 飞机由一个或多个桅杆支撑，因为提升气体被注入以实现所需的浮力用于发射。 然后飞机被释放并且例如以倾斜的方向上升。 当飞机爬升时，提升气体在信封中膨胀，并且第二气体从其中排出。 在水平下降期间，可以将空气泵送到信封中，以将信封保持在基本上充满的配置。 空气和提升气体可以混合，以避免晃动和汇集。

公开(公告)号：US07055778B2

公开(公告)日：2006-06-06

申请号：US10752425

申请日：2004-01-06

Applicant: Martin Eberle ,  Tim Rabel

Inventor： Martin Eberle ,  Tim Rabel

IPC: B64B1/02

CPC classification number: B64F1/14 ,  B64B1/58 ,  B64B1/66

Abstract: An apparatus and associated method for launching and recovering a lighter-than-air aircraft are provided. The aircraft includes an envelope that is substantially filled before launch with a lift gas and a second gas. The lift gas and second gas are substantially separated in the envelope by a boundary layer of mixed gas, formed by the lift and second gases. The aircraft is supported by one or more masts as the lift gas is injected to achieve the required buoyancy for launch. The aircraft is then released and rises, for example, in an inclined orientation. As the aircraft climbs, the lift gas expands in the envelope, and the second gas is vented therefrom. During horizontal descent, air can be pumped into the envelope to maintain the envelope in a substantially filled configuration. The air and lift gas can be mixed to avoid sloshing and pooling.

Abstract translation: 提供了一种用于发射和恢复轻型飞机的装置和相关方法。 该飞机包括一个信封，其在发射之前用提升气体和第二个气体基本上被填充。 提升气体和第二气体通过由升力和第二气体形成的混合气体的边界层在壳体中基本分离。 飞机由一个或多个桅杆支撑，因为提升气体被注入以实现所需的浮力用于发射。 然后飞机被释放并且例如以倾斜的方向上升。 当飞机爬升时，提升气体在信封中膨胀，并且第二气体从其中排出。 在水平下降期间，可以将空气泵送到信封中，以将信封保持在基本上充满的配置。 空气和提升气体可以混合，以避免晃动和汇集。

公开(公告)号：US20050234125A1

公开(公告)日：2005-10-20

申请号：US10517977

申请日：2003-06-18

Applicant: Martin Eberle ,  Daniel Stierli ,  Urs Muller

Inventor： Martin Eberle ,  Daniel Stierli ,  Urs Muller

IPC: A01N41/06 ,  A01N41/10 ,  A01N43/16 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/60 ,  A01N43/653 ,  A01N43/78 ,  A01N43/824 ,  A01N43/836 ,  A01N47/16 ,  A01N47/38 ,  C07C303/38 ,  C07C303/40 ,  C07C311/13 ,  C07C317/20 ,  C07C323/20 ,  C07D207/26 ,  C07D207/27 ,  C07D213/30 ,  C07D213/64 ,  C07D213/643 ,  C07D213/74 ,  C07D213/85 ,  C07D215/20 ,  C07D231/12 ,  C07D233/54 ,  C07D233/60 ,  C07D239/26 ,  C07D239/42 ,  C07D239/46 ,  C07D239/60 ,  C07D241/42 ,  C07D249/08 ,  C07D271/10 ,  C07D277/20 ,  C07D277/24 ,  C07D277/34 ,  C07D277/36 ,  C07D277/42 ,  C07D285/08 ,  C07D285/12 ,  C07D295/18 ,  C07D295/205 ,  C07D295/215 ,  C07D311/16 ,  A01N37/34 ,  C07C317/32

CPC classification number: C07D207/27 ,  A01N41/06 ,  A01N43/36 ,  A01N43/40 ,  A01N43/50 ,  A01N43/56 ,  A01N43/653 ,  A01N43/78 ,  C07C311/13 ,  C07C317/20 ,  C07C323/20 ,  C07D213/30 ,  C07D213/643 ,  C07D213/85 ,  C07D231/12 ,  C07D233/54 ,  C07D239/26 ,  C07D239/42 ,  C07D239/60 ,  C07D241/42 ,  C07D249/08 ,  C07D271/10 ,  C07D277/24 ,  C07D277/34 ,  C07D277/36 ,  C07D277/42 ,  C07D285/08 ,  C07D285/12 ,  C07D295/205 ,  C07D295/215

Abstract: The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substituted aryl or heteroaryl group, R1, and R2 stand independently of each other for hydrogen, optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R3 designates hydrogen, C3-C5alkenyl, C3-C5alkynyl or optionally substituted C1,-C5alkyl; R4 is optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R5 and R6 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R7, and R8 are independently of each other hydrogen or optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; W designates a bridge selected from —O— —S(O)m- or —NR3—; X designates a direct bond or a bridge selected from —O—, —S(O)m- or —NR3—; a and b independently of each other stand for a number 1, 2 or 3; and c and m independently of each other stand for a number zero, 1 or 2. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.