METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS
    2.
    发明申请
    METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS 失效
    与DEHYDRONS包裹相关的方法和组合物

    公开(公告)号:US20130131076A1

    公开(公告)日:2013-05-23

    申请号:US11927329

    申请日:2007-10-29

    IPC分类号: A61K31/506

    CPC分类号: A61K31/506 C07D401/04

    摘要: This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.

    摘要翻译: 该应用描述了药物发现和药物成像/检测中的新技术:包装技术。 该技术基于可溶性蛋白质结构中确定的奇异点。 与基于标准结构考虑的药物设计方法相比,蛋白质的包装,或更准确地说,其脱水剂图案可以用作选择性过滤器来设计小分子抑制剂。 本文描述的包装技术是用于避免药物治疗中的副作用并且锐化药物对肿瘤细胞的抑制作用的合理药物设计的新型形式。

    Surface modified bi-component polymeric fiber
    7.
    发明申请
    Surface modified bi-component polymeric fiber 审中-公开
    表面改性双组分聚合物纤维

    公开(公告)号:US20070122614A1

    公开(公告)日:2007-05-31

    申请号:US11290145

    申请日:2005-11-30

    IPC分类号: D02G3/36 D02G3/02 D02G3/22

    摘要: The present invention provides a bicomponent fiber having increased surface roughness. The fiber includes a first polymer and a composite, wherein the composite forms a layer which forms at least a portion of the fiber's surface. The composite is formed by a second polymer and a filler, where an average particle size of the filler can be greater than a thickness of the layer formed by the composite. The fibers can have a round, oval, trilobal, triangular, dog-boned, flat or hollow shape and a symmetrical or asymmetrical sheath/core or side-by-side configuration. When the fiber has a sheath/core configuration, the composite can form the sheath, and the average particle size of the filler can be greater than the thickness of the sheath.

    摘要翻译: 本发明提供了具有增加的表面粗糙度的双组分纤维。 纤维包括第一聚合物和复合材料,其中复合物形成形成纤维表面的至少一部分的层。 复合材料由第二聚合物和填料形成,其中填料的平均粒径可以大于由复合材料形成的层的厚度。 纤维可以具有圆形,椭圆形,三叶形,三角形,狗骨形,扁平或中空形状和对称或不对称的护套/芯或并排配置。 当纤维具有鞘/芯构造时,复合材料可以形成护套,并且填料的平均粒径可以大于护套的厚度。

    APPARATUS AND METHOD FOR MONITORING BIOLOGICAL CELL CULTURE
    10.
    发明申请
    APPARATUS AND METHOD FOR MONITORING BIOLOGICAL CELL CULTURE 失效
    用于监测生物细胞培养的装置和方法

    公开(公告)号:US20050254055A1

    公开(公告)日:2005-11-17

    申请号:US11160058

    申请日:2005-06-07

    申请人: Hong Peng

    发明人: Hong Peng

    IPC分类号: C12M1/34 G01N21/00 G01N21/51

    CPC分类号: G01N21/51 C12M41/36

    摘要: An apparatus and method for real-time and on-line monitoring the cell growth and concentration in a dynamic cell culture environment, with techniques that suppressing noise from ambient light, non-uniform scattering distribution, bubble and interface reflection effects in the dynamic environment.

    摘要翻译: 一种用于在动态细胞培养环境中实时和在线监测细胞生长和浓度的装置和方法,其具有在动态环境中抑制来自环境光的噪声,不均匀散射分布,气泡和界面反射效应的技术。