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    Azoline Compound and Azole Compound Library and Method for Producing Same
    1.
    发明申请
    Azoline Compound and Azole Compound Library and Method for Producing Same 审中-公开
    唑啉化合物和唑类化合物库及其制备方法

    公开(公告)号：US20140113830A1

    公开(公告)日：2014-04-24

    申请号：US14003506

    申请日：2012-03-09

    申请人： Hiroaki Suga ,  Yuki Goto ,  Yumi Ito

    发明人： Hiroaki Suga ,  Yuki Goto ,  Yumi Ito

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  C07K14/47 ,  C12N15/1062 ,  C12P17/16 ,  C12P21/02 ,  C12Q1/37 ,  G01N2500/00

    摘要： An object of the present invention is to provide a method of efficiently constructing a library abundant in diversity and also usable for screening of a compound that binds to a target substance having protease activity.The present invention provides a method of constructing an azoline compound library containing two or more azoline compounds having an azoline backbone introduced into at least one of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof of Xaa0 of a peptide represented by the following formula (I): A-(Xaa0)n-B  (I) [wherein, m numbers of Xaa0s respectively represent arbitrary amino acids, at least one of which is an amino acid selected from the group consisting of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof, m represents an inter selected from 2 to 40, and A and B each independently represent a peptide composed of from 0 to 100 amino acids].

    摘要翻译： 本发明的目的是提供一种有效地构建多样性丰富的文库并且也可用于筛选结合具有蛋白酶活性的目标物质的化合物的方法。 本发明提供一种构建含有两个或更多个具有引入到Cys，Ser，Thr和2,3-二氨基酸中的至少一种的唑啉主链的二环或二唑化合物的唑啉化合物文献的方法，以及肽类似物的Xaa0 由下式（I）表示：A-（Xaa0）nB（I）[其中，Xaa0的m个数分别表示任意氨基酸，其中至少一个是选自Cys，Ser， Thr和2,3-二氨基酸及其类似物，m表示选自2至40个，A和B各自独立地表示由0至100个氨基酸组成的肽]。

    Methods for ribosomal synthesis of polypeptides containing unnatural N-terminal groups and applications thereof
    2.
    发明授权
    Methods for ribosomal synthesis of polypeptides containing unnatural N-terminal groups and applications thereof 有权
    含有非天然N端基的多肽的核糖体合成方法及其应用

    公开(公告)号：US08557542B2

    公开(公告)日：2013-10-15

    申请号：US12515074

    申请日：2007-11-13

    申请人： Hiroaki Suga ,  Hiroshi Murakami ,  Yuki Goto ,  Atsushi Ohta

    发明人： Hiroaki Suga ,  Hiroshi Murakami ,  Yuki Goto ,  Atsushi Ohta

    IPC分类号： C12P21/06

    CPC分类号： C12N15/67 ,  C12P21/02

    摘要： The present invention aims to synthesize a polypeptide having an unnatural structure at the N-terminus via a biosynthetic process by translation of amino acid sequence information encoded by a nucleic acid. A polypeptide having any amino acid at the N-terminus is synthesized by using an ARS ribozyme that catalyzes the acylation of tRNA with any amino acid to attach any amino acid to an initiator tRNA, thereby initiating a translation with the initiator tRNA.

    摘要翻译： 本发明旨在通过生物合成方法通过翻译由核酸编码的氨基酸序列信息在N末端合成具有非天然结构的多肽。 通过使用催化tRNA与任何氨基酸酰化以将任何氨基酸连接至引发剂tRNA的ARS核酶合成在N末端具有任何氨基酸的多肽，从而开始与引发剂tRNA的翻译。

    Quorum sensing inhibitor
    3.
    发明授权
    Quorum sensing inhibitor 失效
    法定感测抑制剂

    公开(公告)号：US08507674B2

    公开(公告)日：2013-08-13

    申请号：US12739554

    申请日：2008-11-12

    申请人： Hiroaki Suga ,  Jun Igarashi

    发明人： Hiroaki Suga ,  Jun Igarashi

    IPC分类号： C07D239/70

    CPC分类号： A01N43/90 ,  C07D471/04

    摘要： The present invention provides a control agent that is extremely effective in controlling bacterial diseases. The quorum sensing inhibitor and bacterial disease control agent for agricultural and horticultural use of the present invention contain a pyrimidinone compound represented by General Formula (1): wherein R1 represents a C1-5 alkyl group or a phenyl group, and R2 represents a hydrogen atom or a C1-5 alkyl group, provided that R1 cannot be a methyl group when R2 represents a hydrogen atom.

    摘要翻译： 本发明提供一种在控制细菌性疾病方面非常有效的控制剂。 本发明的用于农业和园艺用途的群体感应抑制剂和细菌性疾病防治剂含有通式（1）表示的嘧啶酮化合物：其中R1表示C1-5烷基或苯基，R2表示氢原子 或C 1-5烷基，条件是当R 2表示氢原子时，R 1不能为甲基。

    Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same
    4.
    发明授权
    Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same 失效
    酰胺化合物或其盐，生物膜抑制剂，生物膜去除剂和含有它们的消毒剂

    公开(公告)号：US08258307B2

    公开(公告)日：2012-09-04

    申请号：US11935512

    申请日：2007-11-06

    申请人： Hiroaki Suga ,  Jun Igarashi

    发明人： Hiroaki Suga ,  Jun Igarashi

    IPC分类号： C07D211/56 ,  A61K31/445

    CPC分类号： C07D207/50 ,  A01N43/36 ,  A01N43/40 ,  A61K8/4913 ,  A61K8/4926 ,  A61Q11/00 ,  A61Q17/005 ,  C07D207/14 ,  C07D211/58 ,  C07D295/32

    摘要： The present invention provides a new amide compound and salt thereof that is capable of inhibiting biofilm formation or removing deposited biofilms. The present invention also provides a biofilm formation inhibitor or a biofilm remover containing the amide compound or salt thereof as an active ingredient.An amide compound or salt thereof according to the present invention is denoted by General Formula (1): wherein R1 is a hydrogen atom or a hydroxyl group, R2 is a C5-12 alkyl group, and Q is a substituent denoted by Formula (Q1) or (Q2), wherein n and m are 0 or 1.

    摘要翻译： 本发明提供了能够抑制生物膜形成或去除沉积的生物膜的新的酰胺化合物及其盐。 本发明还提供了含有酰胺化合物或其盐作为活性成分的生物膜形成抑制剂或生物膜去除剂。 根据本发明的酰胺化合物或其盐由通式（1）表示：其中R1是氢原子或羟基，R2是C5-12烷基，Q是由式（Q1）表示的取代基 ）或（Q2），其中n和m为0或1。

    AMIDE COMPOUND AND BACTERIAL DISEASE CONTROL AGENT FOR AGRICULTURAL AND HORTICULTURAL USE
    5.
    发明申请
    AMIDE COMPOUND AND BACTERIAL DISEASE CONTROL AGENT FOR AGRICULTURAL AND HORTICULTURAL USE 失效
    用于农业和农业用途的化合物和细菌病害控制剂

    公开(公告)号：US20100261920A1

    公开(公告)日：2010-10-14

    申请号：US12740064

    申请日：2008-11-06

    申请人： Hiroaki Suga ,  Jun Igarashi

    发明人： Hiroaki Suga ,  Jun Igarashi

    IPC分类号： C07C233/33 ,  C07C235/80

    CPC分类号： C07C233/32 ,  A01N37/18 ,  A01N37/42 ,  C07C235/14 ,  C07C235/80 ,  C07C2601/16

    摘要： The present invention provides an amide compound having antibacterial activity, and a bacterial infection control agent for agricultural and horticultural use that contains the amide compound. The novel amide compound of the present invention is represented by General Formula (1): wherein R is a —CH(R1)(R2) or a —CO(R2) group, R1 is a hydrogen atom or a hydroxyl group, and R2 is a C1-12 alkyl group.

    摘要翻译： 本发明提供具有抗菌活性的酰胺化合物和含有酰胺化合物的农业和园艺用细菌感染控制剂。 本发明的新型酰胺化合物由通式（1）表示：其中R是-CH（R 1）（R 2）或-CO（R 2）基团，R 1是氢原子或羟基，R 2 是C1-12烷基。

    Catalytic RNAs with aminoacylation activity
    7.
    发明授权
    Catalytic RNAs with aminoacylation activity 有权
    具有氨基酰化活性的催化RNA

    公开(公告)号：US07001723B1

    公开(公告)日：2006-02-21

    申请号：US09721414

    申请日：2000-11-22

    申请人： Hiroaki Suga ,  Dimitrios Kourouklis ,  Hirohide Saito ,  Nick Lee ,  Neil Bonzagni

    发明人： Hiroaki Suga ,  Dimitrios Kourouklis ,  Hirohide Saito ,  Nick Lee ,  Neil Bonzagni

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/12

    摘要： The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans aminoacylation activity only have the catalytic domain. A method is provided for constructing and screening of these molecules. These molecules are suitable for aminoacylating tRNA-like molecules with specific amino acids.

    摘要翻译： 本发明提供具有顺式或反式氨基酰化活性的催化RNA分子。 具有顺式氨基酰化活性的催化RNA分子包含催化结构域和氨基酰化结构域。 具有反氨基酰化活性的催化RNA分子仅具有催化结构域。 提供了构建和筛选这些分子的方法。 这些分子适用于具有特定氨基酸的氨基酰化tRNA样分子。

    Azoline compound and azole compound library and method for producing same
    8.
    发明授权
    Azoline compound and azole compound library and method for producing same 有权

    公开(公告)号：US10197567B2

    公开(公告)日：2019-02-05

    申请号：US14003506

    申请日：2012-03-09

    申请人： Hiroaki Suga ,  Yuki Goto ,  Yumi Ito

    发明人： Hiroaki Suga ,  Yuki Goto ,  Yumi Ito

    IPC分类号： C12N15/10 ,  G01N33/543 ,  C12Q1/37 ,  C07K14/47 ,  C12P21/02 ,  C12P17/16

    摘要： An object of the present invention is to provide a method of efficiently constructing a library abundant in diversity and also usable for screening of a compound that binds to a target substance having protease activity.The present invention provides a method of constructing an azoline compound library containing two or more azoline compounds having an azoline backbone introduced into at least one of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof of Xaa0 of a peptide represented by the following formula (I): A-(Xaa0)n-B  (I) [wherein, m numbers of Xaa0s respectively represent arbitrary amino acids, at least one of which is an amino acid selected from the group consisting of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof, m represents an inter selected from 2 to 40, and A and B each independently represent a peptide composed of from 0 to 100 amino acids].

    Peptide library production method, peptide library, and screening method
    9.
    发明授权
    Peptide library production method, peptide library, and screening method 有权

    公开(公告)号：US10195578B2

    公开(公告)日：2019-02-05

    申请号：US13990180

    申请日：2011-12-05

    申请人： Hiroaki Suga ,  Jumpei Morimoto

    发明人： Hiroaki Suga ,  Jumpei Morimoto

    IPC分类号： C40B50/06 ,  B01J19/00 ,  C12N15/10 ,  C12N15/67 ,  C07K7/08 ,  C12Q1/34 ,  C07K14/705 ,  C40B50/08

    摘要： Object is to provide a method of constructing a library of peptides having, at a desired position in the random sequence of each peptide, an amino acid having a portion capable of binding to a target. The invention provides a method of producing a library of peptides having, at a designated position in the random sequence of each peptide, a special amino acid having a portion capable of binding to a target, including (i) preparing a library of mRNAs having, in the mRNA sequence coding for a random amino acid sequence, a base sequence having an altered codon encoding the special amino acid, (ii) preparing an aminoacyl tRNA with the special amino acid linked to a tRNA encoded by the altered codon, and (iii) translating the mRNAs by using a cell-free translation system containing the aminoacyl tRNA to obtain a library of peptides having, in the random sequence thereof, a predetermined special amino acid.

    Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same
    10.
    发明授权
    Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same 失效
    酰胺化合物或其盐，生物膜抑制剂，生物膜去除剂和含有它们的消毒剂

    公开(公告)号：US08748617B2

    公开(公告)日：2014-06-10

    申请号：US13567695

    申请日：2012-08-06

    申请人： Hiroaki Suga ,  Jun Igarashi

    发明人： Hiroaki Suga ,  Jun Igarashi

    IPC分类号： C07D211/56 ,  A01N43/40

    CPC分类号： C07D207/50 ,  A01N43/36 ,  A01N43/40 ,  A61K8/4913 ,  A61K8/4926 ,  A61Q11/00 ,  A61Q17/005 ,  C07D207/14 ,  C07D211/58 ,  C07D295/32

    摘要： The present invention provides a new amide compound and salt thereof that is capable of inhibiting biofilm formation or removing deposited biofilms. The present invention also provides a biofilm formation inhibitor or a biofilm remover containing the amide compound or salt thereof as an active ingredient.An amide compound or salt thereof according to the present invention is denoted by General Formula (1): wherein R1 is a hydrogen atom or a hydroxyl group, R2 is a C5-12 alkyl group, and Q is a substituent denoted by Formula (Q1) or (Q2), wherein n and m are 0 or 1.

    摘要翻译： 本发明提供了能够抑制生物膜形成或去除沉积的生物膜的新的酰胺化合物及其盐。 本发明还提供了含有酰胺化合物或其盐作为活性成分的生物膜形成抑制剂或生物膜去除剂。 根据本发明的酰胺化合物或其盐由通式（1）表示：其中R1是氢原子或羟基，R2是C5-12烷基，Q是由式（Q1）表示的取代基 ）或（Q2），其中n和m为0或1。