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    Process for the production of mannitol by immobilized micro-organisms
    5.
    发明授权
    Process for the production of mannitol by immobilized micro-organisms 失效
    通过固定化微生物生产甘露醇的方法

    公开(公告)号：US06602691B1

    公开(公告)日：2003-08-05

    申请号：US09743342

    申请日：2001-01-09

    申请人： Heikki Ojamo ,  Hannu Koivikko ,  Heikki Heikkilä

    发明人： Heikki Ojamo ,  Hannu Koivikko ,  Heikki Heikkilä

    IPC分类号： C12P718

    CPC分类号： C12N11/08 ,  C12P7/18

    摘要： The invention relates to the production of mannitol by bioconversion with the aid of immobilized micro-organisms as well as to the use of the mannitol and by-products formed in the conversion process. In said process a solution containing a substrate convertible into mannitol is fed into contact with solid carrier particles containing viable mannitol-forming microorganism cells immobilized in and/or on said particles. The solution is reconditioned between successive conversion steps in order to provide conversion of a major portion of said substrate into mannitol.

    摘要翻译： 本发明涉及通过固定微生物的生物转化生产甘露醇，以及在转化过程中形成的甘露糖醇和副产物的用途。 在所述方法中，将含有可转化为甘露糖醇的底物的溶液与含有固定在所述颗粒中和/或所述颗粒上的含活性的形成甘露糖的微生物细胞的固体载体颗粒进行接触。 在连续转化步骤之间对该溶液进行再生，以提供所述底物的主要部分转化为甘露糖醇。

    Method for the production of xylitol
    6.
    发明授权
    Method for the production of xylitol 失效
    生产木糖醇的方法

    公开(公告)号：US07482144B2

    公开(公告)日：2009-01-27

    申请号：US10341220

    申请日：2003-01-13

    申请人： Heikki Ojamo ,  Merja Penttila ,  Heikki Heikkila ,  Jaana Uusitalo ,  Marja Ilmen ,  Marja-Leena Sarkki ,  Maija-Leena Vehkomaki

    发明人： Heikki Ojamo ,  Merja Penttila ,  Heikki Heikkila ,  Jaana Uusitalo ,  Marja Ilmen ,  Marja-Leena Sarkki ,  Maija-Leena Vehkomaki

    IPC分类号： C12P7/18 ,  C12N7/16 ,  C12N1/18

    CPC分类号： C12P7/18

    摘要： The invention relates to a method for the production of xylitol, the method comprising (a1) providing (i) a microorganism having xylanolytic activity, and (ii) a microorganism capable of converting a pentose sugar to xylitol; or (a2) providing a microorganism having xylanolytic activity and being capable of converting a pentose sugar to xylitol, (b) culturing the microorganism of step (a1) (i) or the microorganism of step (a2) in a medium comprising polymer or oligomer materials containing pentose sugars in conditions sufficient for enabling hydrolysis of said polymers or oligomers by the microorganism; (c) producing xylitol in the microorganism of step (a1) (ii) or in the microorganism of step (a2) by bioconversion of the hydrolysis products obtained in step (b), and (d) recovering said xylitol produced. The invention also relates to a microorganism, which has xylanolytic activity and has been genetically modified (i) to enhance its xylanolytic activity, and (ii) to reduce its xylitol metabolism.

    摘要翻译： 本发明涉及一种生产木糖醇的方法，所述方法包括（a1）提供（i）具有木聚糖分解活性的微生物和（ii）能够将戊糖转化成木糖醇的微生物; 或（a2）提供具有木聚糖分解活性并能够将戊糖转化为木糖醇的微生物，（b）在包含聚合物或低聚物的培养基中培养步骤（a1）（i）的微生物或步骤（a2）的微生物） 在足以使微生物水解所述聚合物或低聚物的条件下含有戊糖的材料; （c）通过步骤（b）中获得的水解产物的生物转化和（d）回收所生产的木糖醇，在步骤（a1）（ⅱ）的微生物中或在步骤（a2）的微生物中生产木糖醇。 本发明还涉及一种具有木聚糖分解活性且经遗传修饰的微生物（i）增强其木聚糖分解活性，和（ii）降低其木糖醇代谢。