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22 条记录 (耗时 0.024 秒)

    Peptides and related molecules that bind to TALL-1
    2.
    发明授权
    Peptides and related molecules that bind to TALL-1 有权
    结合TALL-1的肽和相关分子

    公开(公告)号：US07737111B2

    公开(公告)日：2010-06-15

    申请号：US11272521

    申请日：2005-11-10

    申请人： Hosung Min ,  Hailing Hsu ,  Fei Xiong

    发明人： Hosung Min ,  Hailing Hsu ,  Fei Xiong

    IPC分类号： A61K38/10

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  C07K1/047 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/7151 ,  C07K16/241 ,  C07K2319/30 ,  C07K2319/74 ,  C12N15/1037 ,  C40B40/02

    摘要： The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO:100) a1a2a3CDa6La8a9a10Ca12a13a14, (SEQ. ID. NO:104) b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ. ID. NO:105) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ. ID. NO:106) d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18 (SEQ. ID. NO:107) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ. ID NO:109) f1f2f3Kf5Df7Lf9f10Qf12f13f14 wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a—V1—(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.

    摘要翻译： 本发明涉及调节TALL-1活性的治疗剂。 根据本发明，TALL-1的调节剂可以包含氨基酸序列Dz2Lz4，其中z2是氨基酸残基，z4是苏氨酰基或异亮氨酰基。 示例性分子包括下式的一个序列（SEQ。ID NO：100）a1a2a3CDa6La8a9a10Ca12a13a14，（SEQ ID NO：104）b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18（SEQ ID。NO：105）c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18（SEQ ID。NO：106）d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18（ SEQ ID NO：107）e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18（SEQ ID NO：109）f1f2f3Kf5Df7Lf9f10Qf12f13f14其中取代基如说明书中所定义。 本发明还包括式（X1）a-V1-（X2）b的物质的组合物，其中V1是共价连接到一种或多种上述TALL-1调节组合物的载体。 载体和TALL-1调节组合物可以通过TALL-1调节部分的N末端或C末端连接。 优选的载体是Fc结构域，优选的Fc结构域是IgG Fc结构域。

    Peptides and related molecules that bind to TALL-1
    3.
    发明申请
    Peptides and related molecules that bind to TALL-1 有权

    公开(公告)号：US20060135431A1

    公开(公告)日：2006-06-22

    申请号：US11272521

    申请日：2005-11-10

    申请人： Hosung Min ,  Hailing Hsu ,  Fei Xiong

    发明人： Hosung Min ,  Hailing Hsu ,  Fei Xiong

    IPC分类号： A61K38/10 ,  C07K7/08

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  C07K1/047 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/7151 ,  C07K16/241 ,  C07K2319/30 ,  C07K2319/74 ,  C12N15/1037 ,  C40B40/02

    摘要： The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO:100) a1a2a3CDa6La8a9a10Ca12a13a14, (SEQ. ID. NO:104) b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ. ID. NO:105) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ. ID. NO:106) d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18 (SEQ. ID. NO:107) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ. ID NO:109) f1f2f3Kf5Df7Lf9f10Qf12f13f14 wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.

    TNF receptor-associated intracellular signaling proteins and methods of use
    5.
    发明授权
    TNF receptor-associated intracellular signaling proteins and methods of use 失效
    TNF受体相关的细胞内信号蛋白和使用方法

    公开(公告)号：US5563039A

    公开(公告)日：1996-10-08

    申请号：US414625

    申请日：1995-03-31

    申请人： David V. Goeddel ,  Hailing Hsu

    发明人： David V. Goeddel ,  Hailing Hsu

    IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K14/46 ,  C12N15/12 ,  G01N33/566

    CPC分类号： C07K14/7151 ,  A61K38/00

    摘要： A novel family of intracellular signaling proteins, exemplified by a Tumor Necrosis Factor Receptor-1 Associated Death Domain protein (TRADD), share a common TRADD sequence and include transducers of signals that modulate cell growth, differentiation and apoptosis. As such, the TRADD proteins, TRADD-encoding nucleic acids, and natural TRADD intracellular binding targets provide both important targets and means for therapeutic intervention. In particular, the invention provides isolated TRADDs and TRADD fragments, nucleic acids encoding the subject TRADDs and TRADD fragments or capable of selectively hybridizing to such TRADD-encoding nucleic acids, vectors and cells comprising TRADD-encoding nucleic acids, and TRADD-specific binding reagents. These compositions find use in diagnostic and therapeutic methods for disease associated with undesirable cell growth, migration, differentiation and/or cytokine signal responsiveness and methods and compositions for identifying lead compounds and pharmacological agents.

    摘要翻译： 由肿瘤坏死因子受体-1相关死亡域蛋白（TRADD）示例的新型细胞内信号蛋白家族共享一个常见的TRADD序列，并且包括调节细胞生长，分化和凋亡的信号转导子。 因此，TRADD蛋白，TRADD编码核酸和天然TRADD细胞内结合靶标为治疗干预提供了重要的目标和手段。 特别地，本发明提供了分离的TRADD和TRADD片段，编码主题TRADD和TRADD片段的核酸或能够选择性地与编码这种TRADD编码核酸，载体和包含TRADD编码核酸的细胞和TRADD特异性结合试剂 。 这些组合物用于与不良细胞生长，迁移，分化和/或细胞因子信号反应性相关的疾病的诊断和治疗方法以及用于鉴定铅化合物和药理学试剂的方法和组合物。

    Nucleic acids encoding NTR3, a member of the TNF-receptor supergene family
    9.
    发明授权
    Nucleic acids encoding NTR3, a member of the TNF-receptor supergene family 失效
    编码NTR3的核酸，TNF受体超基因家族的成员

    公开(公告)号：US06599716B1

    公开(公告)日：2003-07-29

    申请号：US09632277

    申请日：2000-08-03

    申请人： Hailing Hsu

    发明人： Hailing Hsu

    IPC分类号： C12P2102

    CPC分类号： C07K14/70578 ,  A01K2217/05 ,  C12N2799/021

    摘要： The present invention provides a purified polynucleotide encoding a novel receptor, designated NTR3, which belongs to the TNF receptor gene superfamily; to purified NTR3 polypeptide molecules; to antibodies that bind NTR3; to materials comprising such molecules; and to methods of using such molecules.

    摘要翻译： 本发明提供了编码属于TNF受体基因超家族的NTR3的新型受体的纯化多核苷酸; 纯化的NTR3多肽分子; 结合NTR3的抗体; 包括这种分子的材料; 以及使用这种分子的方法。