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公开(公告)号：US07968325B2
公开(公告)日：2011-06-28
申请号：US10867537
申请日：2004-06-14
IPC分类号： C12N1/20 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N15/00 , C12N5/00 , C12N5/10 , C12N1/00 , C12N1/14 , C07H21/04
CPC分类号： C12N9/93 , C07H21/04 , C12N9/1029 , C12N9/13 , C12N15/8243 , C12P7/625
摘要： Coexpression of a polyhydroxyalkanoic acid synthase and a either a fatty acid:acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed.
摘要翻译： 聚羟基链烷酸合酶和细胞中的脂肪酸：酰基-CoA转移酶或酰基辅酶A合成酶的共表达能够使聚酯材料的生物合成。 公开了用于制备聚酯的质粒，细菌，材料和方法。
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2.发明申请Novel Gene Products From Bacillus Licheniformis Forming Or Decomposing Polyamino Acids And Improved Biotechnological Production Methods Based Thereon 有权来自地衣芽孢杆菌形成或分解聚氨基酸的新型基因产物及其改进的生物技术生产方法公开(公告)号：US20070190604A1
公开(公告)日：2007-08-16
申请号：US11611945
申请日：2006-12-18
申请人： Jorg FEESCHE , Cornelius BESSLER , Stefan EVERS , Karl-Heinz MAURER , Armin EHRENREICH , Birgit VEITH , Heiko LIESEGANG , Anke HENNE , Christina HERZBERG , Gerhard GOTTSCHALK
发明人： Jorg FEESCHE , Cornelius BESSLER , Stefan EVERS , Karl-Heinz MAURER , Armin EHRENREICH , Birgit VEITH , Heiko LIESEGANG , Anke HENNE , Christina HERZBERG , Gerhard GOTTSCHALK
摘要： The invention relates to five or four novel genes and the gene products thereof from Bacillus licheniformis and sufficiently similar genes and proteins which are involved in vivo in the formation of polyamino acids. The gene in question is ywsC, ywsC′, ywtA, ywtB and ywtD or proteins coded thereby. The gene ywsC, ywsC′, ywtA and ywtB can be used to improve biotechnological production methods by microorganisms, wherein they are functionally inactivated; the gene ywtD which codes for a peptide decomposing poly-gamma glutamate can, inversely, contribute to the improvement of biotechnological production methods by increased expression. Said genes can be used positively, preferably to result in a modification or decomposition of poly-gamma glutamate.
摘要翻译： 本发明涉及5或4种新型基因及其从地衣芽孢杆菌中得到的基因产物以及与体内在聚氨基酸形成有关的充分相似的基因和蛋白质。 所讨论的基因是ywsC，ywsC'，ywtA，ywtB和ywtD或由此编码的蛋白质。 基因ywsC，ywsC'，ywtA和ywtB可用于通过微生物改善生物技术生产方法，其中它们在功能上失活; 编码分解聚-γ谷氨酸的肽的基因ywtD可以相反地通过增加表达来促进生物技术生产方法的改进。 所述基因可以积极使用，优选导致聚-γ谷氨酸的修饰或分解。
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公开(公告)号：US07205140B2
公开(公告)日：2007-04-17
申请号：US10689564
申请日：2003-10-20
CPC分类号： C12Y305/04021 , C12N9/78
摘要： The present invention relates to the discovery of novel genes encoding a polypeptide having creatinine deiminase activity and methods of use. Also disclosed is a kit using the novel sequences for determining the concentration of creatinine in a sample.
摘要翻译： 本发明涉及编码具有肌酐去酰亚胺酶活性的多肽和使用方法的新基因的发现。 还公开了使用用于测定样品中肌酸酐浓度的新序列的试剂盒。
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4.发明申请公开(公告)号：US20070190605A1
公开(公告)日：2007-08-16
申请号：US11616319
申请日：2006-12-27
申请人： Cornelius Bessler , Jorg Feesche , Stefan Evers , Karl-Heinz Maurer , Armin Ehrenreich , Birgit Veith , Heiko Liesegang , Anke Henne , Christina Herzberg , Gerhard Gottschalk
发明人： Cornelius Bessler , Jorg Feesche , Stefan Evers , Karl-Heinz Maurer , Armin Ehrenreich , Birgit Veith , Heiko Liesegang , Anke Henne , Christina Herzberg , Gerhard Gottschalk
IPC分类号： C07H21/04 , C12P21/06 , C12P7/40 , C12N9/02 , C12N9/16 , C12N9/32 , C12N9/42 , C12N9/50 , C12N9/64 , C12N15/74 , C12N1/21
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12N9/16 , C12N9/78 , C12N9/80 , C12N9/84 , C12N9/88 , C12N9/93 , C12N15/75 , C12P7/16 , C12P7/40 , C12P7/42 , C12P7/52 , C12P13/001 , C12Y101/01 , C12Y101/01035 , C12Y101/01157 , C12Y102/04002 , C12Y103/99 , C12Y203/01019 , C12Y206/01042 , C12Y207/02007 , C12Y305/01001 , C12Y305/01011 , C12Y401/01018 , C12Y401/01019 , C12Y402/01017 , C12Y402/01055 , C12Y602/01 , C12Y602/01001 , Y02E50/10 , Y02P20/52
摘要： The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesized via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.
摘要翻译： 本发明涉及地衣芽孢杆菌的25个迄今未描述的基因及其衍生的基因产物及其全部充分同源的核酸及其蛋白质。 它们发生在五种不同的代谢途径中，用于形成气味物质。 所讨论的代谢途径是用于合成：1）异戊酸（作为亮氨酸分解代谢的一部分），2）2-甲基丁酸和/或异丁酸（作为缬氨酸和/或异亮氨酸分解代谢的一部分） 3）丁醇和/或丁酸（作为丁酸代谢的一部分），4）丙酸（作为丙酸代谢的一部分）和/或5）尸胺和/或腐胺（作为赖氨酸分解代谢的一部分） 和/或精氨酸）。 这些基因的鉴定允许开发生物技术生产方法，其被改进到对于辅助这些核酸的程度，可以通过使微生物中相应的基因失活来减少通过这些代谢途径合成的恶臭物质的形成 用于生物技术生产。 此外，这些基因产物因此可用于制备反应或根据其各自生物化学性质的方法。
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公开(公告)号：US20050084930A1
公开(公告)日：2005-04-21
申请号：US10689564
申请日：2003-10-20
CPC分类号： C12Y305/04021 , C12N9/78
摘要： The present invention relates to the discovery of novel genes encoding a polypeptide having creatinine deiminase activity and methods of use. Also disclosed is a kit using the novel sequences for determining the concentration of creatinine in a sample.
摘要翻译： 本发明涉及编码具有肌酐去酰亚胺酶活性的多肽和使用方法的新基因的发现。 还公开了使用用于测定样品中肌酸酐浓度的新序列的试剂盒。
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公开(公告)号：US06759219B2
公开(公告)日：2004-07-06
申请号：US09380773
申请日：1999-09-03
IPC分类号： C12P762
CPC分类号： C12N9/93 , C07H21/04 , C12N9/1029 , C12N9/13 , C12N15/8243 , C12P7/625
摘要： Coexpression of a polyhydroxyalkanoic acid synthase and either a fatty acid: acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed.
摘要翻译： 聚羟基链烷酸合酶和脂肪酸：酰基-CoA转移酶或酰基-CoA合成酶在细胞中的共表达使得能够生物合成聚酯材料。 公开了用于制备聚酯的质粒，细菌，材料和方法。
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7.发明授权
公开(公告)号：US4929557A
公开(公告)日：1990-05-29
申请号：US176344
申请日：1988-03-31
CPC分类号： C12N9/2457 , C12N9/2411 , C12N9/2417 , C12Y302/01041 , Y10S435/801 , Y10S435/822
摘要： At least one type of excretable, thermostable amylolytic enzyme, such as amylase and pullulanase, can be recovered from a culture medium in which thermophilic anaerobic bacteria, such as Thermoanaerobacter finii or Thermobacteroides acetoethylicus, are propagated anaerobically in continuous culture, in the presence of a higher saccharide as carbon source, such an enzyme having a high stability at temperatures between 60.degree. and 70.degree. C. in absence of metal ions and substrate and under aerobic conditions.
摘要翻译： 可以从培养基中回收至少一种可排除的热稳定淀粉分解酶，例如嗜热厌氧细菌，例如热嗜热杆菌（Thermanaerobacter finii）或嗜热醋杆菌（Thermobacteroides acetoethylicus），在连续培养物中厌氧地繁殖，在 较高的糖类作为碳源，这种酶在不存在金属离子和底物的条件下，在有氧条件下，在60〜70℃的温度下具有高稳定性。
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8.发明授权Gene products of Bacillus licheniformis which form odorous substances and improved biotechnological production methods based thereon 有权其形成气味物质的地衣芽孢杆菌的基因产物和基于其的改良的生物技术生产方法公开(公告)号：US09394528B2
公开(公告)日：2016-07-19
申请号：US11616319
申请日：2006-12-27
申请人： Cornelius Bessler , Jörg Feesche , Stefan Evers , Karl-Heinz Maurer , Armin Ehrenreich , Birgit Veith , Heiko Liesegang , Anke Henne , Christina Herzberg , Gerhard Gottschalk
发明人： Cornelius Bessler , Jörg Feesche , Stefan Evers , Karl-Heinz Maurer , Armin Ehrenreich , Birgit Veith , Heiko Liesegang , Anke Henne , Christina Herzberg , Gerhard Gottschalk
IPC分类号： C12N15/74 , C12N1/20 , C12P21/06 , C12N9/06 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/78 , C12N9/80 , C12N9/88 , C12N9/00 , C12N15/52 , C12P7/16 , C12P7/40 , C12P7/52 , C12P13/00
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12N9/16 , C12N9/78 , C12N9/80 , C12N9/84 , C12N9/88 , C12N9/93 , C12N15/75 , C12P7/16 , C12P7/40 , C12P7/42 , C12P7/52 , C12P13/001 , C12Y101/01 , C12Y101/01035 , C12Y101/01157 , C12Y102/04002 , C12Y103/99 , C12Y203/01019 , C12Y206/01042 , C12Y207/02007 , C12Y305/01001 , C12Y305/01011 , C12Y401/01018 , C12Y401/01019 , C12Y402/01017 , C12Y402/01055 , C12Y602/01 , C12Y602/01001 , Y02E50/10 , Y02P20/52
摘要： The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesized via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.
摘要翻译： 本发明涉及地衣芽孢杆菌的25个迄今未描述的基因及其衍生的基因产物及其全部充分同源的核酸及其蛋白质。 它们发生在五种不同的代谢途径中，用于形成气味物质。 所讨论的代谢途径是用于合成：1）异戊酸（作为亮氨酸分解代谢的一部分），2）2-甲基丁酸和/或异丁酸（作为缬氨酸和/或异亮氨酸分解代谢的一部分） 3）丁醇和/或丁酸（作为丁酸代谢的一部分），4）丙酸（作为丙酸代谢的一部分）和/或5）尸胺和/或腐胺（作为赖氨酸分解代谢的一部分） 和/或精氨酸）。 这些基因的鉴定允许开发生物技术生产方法，其被改进到对于辅助这些核酸的程度，可以通过使微生物中相应的基因失活来减少通过这些代谢途径合成的恶臭物质的形成 用于生物技术生产。 此外，这些基因产物因此可用于制备反应或根据其各自生物化学性质的方法。
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9.发明授权Microorganisms providing novel gene products forming or decomposing polyamino acids 有权提供形成或分解聚氨基酸的新基因产物的微生物公开(公告)号：US07807443B2
公开(公告)日：2010-10-05
申请号：US11611945
申请日：2006-12-18
申请人： Jörg Feesche , Cornelius Bessler , Stefan Evers , Karl-Heinz Maurer , Armin Ehrenreich , Birgit Veith , Heiko Liesegang , Anke Henne , Christina Herzberg , Gerhard Gottschalk
发明人： Jörg Feesche , Cornelius Bessler , Stefan Evers , Karl-Heinz Maurer , Armin Ehrenreich , Birgit Veith , Heiko Liesegang , Anke Henne , Christina Herzberg , Gerhard Gottschalk
摘要： The invention relates to five or four novel genes and the gene products thereof from Bacillus licheniformis and sufficiently similar genes and proteins which are involved in vivo in the formation of polyamino acids. The gene in question is ywsC, ywsC′, ywtA, ywtB and ywtD or proteins coded thereby. The gene ywsC, ywsC′, ywtA and ywtB can be used to improve biotechnological production methods by microorganisms, wherein they are functionally inactivated; the gene ywtD which codes for a peptide decomposing poly-gamma glutamate can, inversely, contribute to the improvement of biotechnological production methods by increased expression. Said genes can be used positively, preferably to result in a modification or decomposition of poly-gamma glutamate.
摘要翻译： 本发明涉及5或4种新型基因及其从地衣芽孢杆菌中得到的基因产物以及与体内在聚氨基酸形成有关的充分相似的基因和蛋白质。 所讨论的基因是ywsC，ywsC'，ywtA，ywtB和ywtD或由此编码的蛋白质。 基因ywsC，ywsC'，ywtA和ywtB可用于通过微生物改善生物技术生产方法，其中它们在功能上失活; 编码分解聚-γ谷氨酸的肽的基因ywtD可以相反地通过增加表达来促进生物技术生产方法的改进。 所述基因可以积极使用，优选导致聚-γ谷氨酸的修饰或分解。
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10.发明授权Process for fermenting carbohydrate- and phosphate-containing liquid media 失效用于发酵含碳水化合物和磷酸盐的液体介质的方法
公开(公告)号：US4605620A
公开(公告)日：1986-08-12
申请号：US442093
申请日：1982-11-16
IPC分类号： C12P7/26 , C12P7/06 , C12P7/16 , C12P7/28 , C12P7/52 , C12P7/54 , C12R1/645 , C12N1/20 , C12Q3/00
摘要： The invention relates to a process for fermenting carbohydrate- and phosphate-containing liquid media with limitation of phosphate with bacteria capable of forming butanol, acetone and/or ethanol as fermentation products performed with a total phosphate content in the medium of 1.0 to 0.4 mmoles.
摘要翻译： 本发明涉及一种使含有碳水化合物和磷酸盐的液体培养基发酵的方法，其中磷酸盐与能够形成丁醇，丙酮和/或乙醇的细菌一起发酵，作为在1.0至0.4毫摩尔培养基中的总磷酸盐含量进行的发酵产物。
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