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31 条记录 (耗时 0.015 秒)

    Compositions and Methods for Generating an Immune Response to a Flavivirus
    3.
    发明申请
    Compositions and Methods for Generating an Immune Response to a Flavivirus 审中-公开

    公开(公告)号：US20190030157A1

    公开(公告)日：2019-01-31

    申请号：US16074947

    申请日：2017-02-01

    申请人： GEOVAX INC.

    发明人： Farshad Guirakhoo ,  Arban Domi ,  Nathanael Paul McCurley

    IPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00

    摘要： The compositions and methods are described for generating an immune response to a flavivirus such as Zika virus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a member of genus Flavivirus (such as a member of species Zika virus), in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat an infection caused by Flavivirus.

    MVA VECTORS EXPRESSING POLYPEPTIDES AND HAVING HIGH LEVEL PRODUCTION IN CERTAIN CELL LINES
    6.
    发明申请
    MVA VECTORS EXPRESSING POLYPEPTIDES AND HAVING HIGH LEVEL PRODUCTION IN CERTAIN CELL LINES 审中-公开
    MVA矢量表达多聚体并具有某些细胞系中的高水平生产

    公开(公告)号：US20130280215A1

    公开(公告)日：2013-10-24

    申请号：US13655294

    申请日：2012-10-18

    申请人： GeoVax, Inc.

    发明人： Harriet L. Robinson

    IPC分类号： C12N15/86

    CPC分类号： C12N15/86 ,  A61K2039/5256 ,  C12N2710/24143 ,  C12N2740/16034 ,  C12N2840/102

    摘要： The present invention provides viral vectors, such as recombinant MVA vectors, that are capable of expressing one or more polypeptides, such as, e.g., HIV proteins or GM-CSF, in the cells of a human patient at relatively high levels and can also be produced in significant quantities in cultured cells. Also provided are methods for producing the viral vectors and pharmaceutical compositions containing them.

    摘要翻译： 本发明提供了能够以较高水平在人类患者的细胞中表达一种或多种多肽（例如HIV蛋白或GM-CSF）的病毒载体，例如重组MVA载体，并且还可以 在培养细胞中大量产生。 还提供了用于生产含有它们的病毒载体和药物组合物的方法。

    VACCINES AND USES THEREOF TO INDUCE AN IMMUNE RESPONSE TO SARS-COV2
    9.
    发明申请
    VACCINES AND USES THEREOF TO INDUCE AN IMMUNE RESPONSE TO SARS-COV2 有权

    公开(公告)号：US20220396810A1

    公开(公告)日：2022-12-15

    申请号：US17888131

    申请日：2022-08-15

    申请人： GeoVax, Inc.

    发明人： Mary Jo Hauser ,  Arban Domi ,  Farshad Guirakhoo

    IPC分类号： C12N15/863 ,  C07K14/005

    摘要： Provided herein are recombinant modified vaccinia Ankara (rMVA) viral vectors comprising heterologous nucleic acid inserts encoding one or more SARS-CoV2 proteins, peptides, or fragments thereof, operably linked to a promoter compatible with poxvirus expression systems that, upon expression, are capable of inducing protective immunity. The compositions can be used in a priming vaccination strategy or in a prime/boost vaccination strategy to provide immunity to SARS-CoV2 and variants thereof.

    Multivalent HIV vaccine boost compositions and methods of use
    10.
    发明授权
    Multivalent HIV vaccine boost compositions and methods of use 有权

    公开(公告)号：US11098086B2

    公开(公告)日：2021-08-24

    申请号：US16077215

    申请日：2017-02-16

    申请人： GEOVAX INC.

    发明人： Harriet Robinson

    IPC分类号： A61K39/21 ,  C07K14/16 ,  C12N15/86

    摘要： Compositions and methods of use are provided to boost a primed immune response to HIV. More specifically, the present invention relates to vaccine compositions comprising an HIV-protein boost or an MVA-expressed Env protein and methods of use. Exemplary HIV proteins for protein boosts include proteins such as gp120 proteins B.63521Δ11mutC and full-length single chain (FLSC), which has been modified to stabilize a CD4-induced Env structure. Exemplary MVAs expressing secreted Methods of administration and dosing regimens are also provided.