- 专利标题: VACCINES AND USES THEREOF TO INDUCE AN IMMUNE RESPONSE TO SARS-COV2
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申请号: US17888131申请日: 2022-08-15
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公开(公告)号: US20220396810A1公开(公告)日: 2022-12-15
- 发明人: Mary Jo Hauser , Arban Domi , Farshad Guirakhoo
- 申请人: GeoVax, Inc.
- 申请人地址: US GA Smyrna
- 专利权人: GeoVax, Inc.
- 当前专利权人: GeoVax, Inc.
- 当前专利权人地址: US GA Smyrna
- 主分类号: C12N15/863
- IPC分类号: C12N15/863 ; C07K14/005
摘要:
Provided herein are recombinant modified vaccinia Ankara (rMVA) viral vectors comprising heterologous nucleic acid inserts encoding one or more SARS-CoV2 proteins, peptides, or fragments thereof, operably linked to a promoter compatible with poxvirus expression systems that, upon expression, are capable of inducing protective immunity. The compositions can be used in a priming vaccination strategy or in a prime/boost vaccination strategy to provide immunity to SARS-CoV2 and variants thereof.
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