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1.发明申请公开(公告)号：US20190290745A1
公开(公告)日：2019-09-26
申请号：US16068527
申请日：2017-01-09
申请人： GEOVAX INC.
发明人： Harriet Robinson , Arban Domi , Michael Hellerstein , Farshad Guirakhoo , Nathanael Paul McCurley
摘要： The compositions and methods are described for generating an immune response to a tumor associated antigen such as MUC1. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a neoplasm expressing the tumor associated antigen in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat neoplasms and associated diseases.
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公开(公告)号：US20230256088A1
公开(公告)日：2023-08-17
申请号：US17950989
申请日：2022-09-22
申请人： GeoVax, Inc.
发明人： Farshad Guirakhoo
IPC分类号： A61K39/285 , A61P35/00 , A61K39/00 , C12N15/86
CPC分类号： A61K39/285 , A61P35/00 , A61K39/00117 , C12N15/86 , A61K2039/5258 , A61K2039/575
摘要： The compositions and methods are described for generating an immune response to a tumor associated antigen such as MUC-1. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to MUC-1 in the subject to which the vector is administered and boosting the immune response by administering a MUC-1 peptide. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat neoplasms and associated diseases.
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3.发明申请公开(公告)号：US20200282036A1
公开(公告)日：2020-09-10
申请号：US16648693
申请日：2018-09-18
申请人： GEOVAX, INC.
IPC分类号： A61K39/015 , A61K47/69 , A61K9/00 , A61P33/06
摘要： The compositions and methods are described for generating an immune response to a Plasmodium antigen. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to malaria by expressing the Plasmodium antigen in the subject to which the MVA vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat malaria.
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公开(公告)号：US20190030157A1
公开(公告)日：2019-01-31
申请号：US16074947
申请日：2017-02-01
申请人： GEOVAX INC.
摘要： The compositions and methods are described for generating an immune response to a flavivirus such as Zika virus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a member of genus Flavivirus (such as a member of species Zika virus), in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat an infection caused by Flavivirus.
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公开(公告)号：US20230040403A1
公开(公告)日：2023-02-09
申请号：US17876682
申请日：2022-07-29
申请人： GeoVax, Inc.
发明人： Harriet Robinson , Arban Domi , Michael Hellerstein , Farshad Guirakhoo , Nathanael Paul McCurley
摘要： The compositions and methods are described for generating an immune response to an antigen. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens as a fusion product with a viral glycoprotein and matrix protein for generating a protective immune response to a subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat diseases.
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公开(公告)号：US20220396810A1
公开(公告)日：2022-12-15
申请号：US17888131
申请日：2022-08-15
申请人： GeoVax, Inc.
发明人： Mary Jo Hauser , Arban Domi , Farshad Guirakhoo
IPC分类号： C12N15/863 , C07K14/005
摘要： Provided herein are recombinant modified vaccinia Ankara (rMVA) viral vectors comprising heterologous nucleic acid inserts encoding one or more SARS-CoV2 proteins, peptides, or fragments thereof, operably linked to a promoter compatible with poxvirus expression systems that, upon expression, are capable of inducing protective immunity. The compositions can be used in a priming vaccination strategy or in a prime/boost vaccination strategy to provide immunity to SARS-CoV2 and variants thereof.
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公开(公告)号：US20200171141A1
公开(公告)日：2020-06-04
申请号：US16631489
申请日：2018-07-18
申请人： GEOVAX, INC.
发明人： Farshad Guirakhoo , Arban Domi
摘要： Compositions and methods are described for generating an immune response to an arenavirus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a member of genus Arenavirus (such as a member of species Lassa virus) in the subject to which the vector is administered. The compositions and methods of the present invention may be used to prevent and/or treat an infection caused by arenavirus.
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公开(公告)号：US11857611B2
公开(公告)日：2024-01-02
申请号：US17726254
申请日：2022-04-21
申请人： Geovax, Inc.
IPC分类号： A61K39/015 , A61K47/69 , A61P33/06 , A61K9/00 , A61K39/00
CPC分类号： A61K39/015 , A61K9/0019 , A61K47/6901 , A61P33/06 , A61K2039/5256 , A61K2039/54
摘要： The compositions and methods are described for generating an immune response to a Plasmodium antigen. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to malaria by expressing the Plasmodium antigen in the subject to which the MVA vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat malaria.
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公开(公告)号：US11638750B2
公开(公告)日：2023-05-02
申请号：US17000768
申请日：2020-08-24
申请人： GEOVAX, INC.
摘要： The compositions and methods are described for generating an immune response to a flavivirus such as Zika virus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a member of genus Flavivirus (such as a member of species Zika virus), in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat an infection caused by Flavivirus.
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公开(公告)号：US11311612B2
公开(公告)日：2022-04-26
申请号：US16648693
申请日：2018-09-18
申请人： GEOVAX, INC.
IPC分类号： A61K39/015 , A61K47/69 , A61P33/06 , A61K9/00 , A61K39/00
摘要： The compositions and methods are described for generating an immune response to a Plasmodium antigen. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to malaria by expressing the Plasmodium antigen in the subject to which the MVA vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat malaria.
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