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    GENETICALLY REPROGRAMMED TREGS EXPRESSING CARS
    2.
    发明申请
    GENETICALLY REPROGRAMMED TREGS EXPRESSING CARS 有权

    公开(公告)号：US20220186232A1

    公开(公告)日：2022-06-16

    申请号：US17598208

    申请日：2020-03-26

    申请人： Gavish-Galilee Bio Applications Ltd.

    发明人： Gideon Gross ,  Hadas Weinstein-Marom ,  Sarah Pozner ,  Amit Kroner

    IPC分类号： C12N15/62 ,  A61P1/00 ,  C07K14/54 ,  C07K14/725 ,  C07K16/12

    摘要： Nucleic acid molecules comprising a nucleotide sequence encoding an activating chimeric antigen receptor (aCARs) are provided, said aCARs comprising (i) an extracellular binding-domain specifically binding an antigen selected from an antigen of the commensal gut microflora and a self-cell surface antigen specific to the lamina propria (LP) or submucosa of the gastrointestinal tract; (ii) a transmembrane domain; (iii) an intracellular domain including at least one signal transduction element that activates and/or co-stimulates a T cell; and optionally (iv) a stalk region linking the extracellular domain and the transmembrane domain. Compositions and vectors comprising the nucleic acid molecules encoding the aCAR as well as methods for preparing regulatory T cells comprising the vectors and expressing the aCARs are further provided as are methods for treating or preventing a disease, disorder or condition manifested in excessive activity of the immune system in a subject, comprising administering to said subject the mammalian Treg expressing on its surface an aCAR. The regulatory T cells optionally express a membrane-bound homodimeric IL-10 conferring a stable Tr1 phenotype.

    SYSTEM FOR TREATMENT OF POLLUTED EFFLUENTS
    3.
    发明申请
    SYSTEM FOR TREATMENT OF POLLUTED EFFLUENTS 有权

    公开(公告)号：US20210292206A1

    公开(公告)日：2021-09-23

    申请号：US17339432

    申请日：2021-06-04

    申请人： GAVISH-GALILEE BIO APPLICATIONS LTD.

    发明人： Giora RYTWO ,  Gonen DASKAL

    IPC分类号： C02F9/00 ,  C02F1/00 ,  B01D65/02 ,  B01D61/14 ,  B01D61/18 ,  B01D61/22 ,  B01D69/02

    摘要： A system for treatment of a polluted effluent includes an outer chamber and a computerized control system. The system is configured to treat an effluent/catalyst mixture that includes the polluted effluent in admixture with a purification slurry. The slurry includes particles of one or more catalysts and/or organoclays. The treatment of the effluent/catalyst mixture is carried out by contact between the particles of the catalysts and/or organoclays and the polluted effluent to mineralize or degrade pollutants in the polluted effluent.