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公开(公告)号：US09376695B2
公开(公告)日：2016-06-28
申请号：US12238704
申请日：2008-09-26
申请人： Rustem Saidovich Shakulov , Elena Vitalievna Klyachko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh
发明人： Rustem Saidovich Shakulov , Elena Vitalievna Klyachko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh
CPC分类号： C12P21/02 , C12N9/001 , C12N9/90 , C12N9/92 , C12P13/20 , C12P13/222 , C12P13/24 , C12Y103/01013 , C12Y503/01009 , C12Y504/99005 , Y02P20/52
摘要： A method for producing an L-amino acid is described, for example, L-phenylalanine and L-histidine, by fermentation using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified by attaching a DNA fragment able to be transcribed encoding the peptide represented in SEQ ID NO: 2, or a variant thereof, particularly a portion of the ssrA gene, to the 3′-end of gene encoding for the bacterial enzyme, which influences on the L-amino acid biosynthesis, such as chorismate mutase/prephenate dehydrogenase or phosphoglucose isomerase.
摘要翻译： 通过使用肠杆菌科的细菌进行发酵，描述了L-氨基酸的制造方法，例如L-苯丙氨酸和L-组氨酸，其中，通过将能够转录的DNA片段连接到编码 SEQ ID NO：2所示的肽，或其变体，特别是ssrA基因的一部分，对编码细菌酶的基因的3'末端，其影响L-氨基酸生物合成，例如绒毛膜变位酶 / prephenate脱氢酶或磷酸葡萄糖异构酶。
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2.发明授权Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine 有权突变型磷酸核糖焦磷酸合成酶及其生产L-组氨酸的方法公开(公告)号：US08071339B2
公开(公告)日：2011-12-06
申请号：US12031757
申请日：2008-02-15
CPC分类号： C12N9/1235 , C12P13/24
摘要： The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene.
摘要翻译： 本发明涉及抗嘌呤核苷酸反馈的突变型细菌PRPP合成酶，以及使用肠杆菌科的细菌产生L-组氨酸的方法，其中所述细菌的L-氨基酸生产力通过使用 PRPP合成酶，其抗嘌呤核苷酸反馈，由突变体prsA基因编码。
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3.发明授权公开(公告)号：US07399618B2
公开(公告)日：2008-07-15
申请号：US11696375
申请日：2007-04-04
CPC分类号： C12P13/24 , C12N9/1022
摘要： A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talB gene.
摘要翻译： 提供了利用肠杆菌科的细菌产生L-组氨酸的方法，其中通过增强talB基因编码的转醛醇酶的活性来增强细菌的L-氨基酸生产力。
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公开(公告)号：US08003368B2
公开(公告)日：2011-08-23
申请号：US12349743
申请日：2009-01-07
申请人： Aleksey Nikolaevich Marchenko , Sergey Vladimirovich Benevolensky , Elena Vitalievna Klyachko , Yuri Ivanovich Kozlov , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner
发明人： Aleksey Nikolaevich Marchenko , Sergey Vladimirovich Benevolensky , Elena Vitalievna Klyachko , Yuri Ivanovich Kozlov , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner
IPC分类号： C12N1/21 , C12N1/20 , C12N15/70 , C12N9/00 , C12P13/04 , C12P13/24 , C07H21/04 , C12P13/14 , C12P13/20 , C12P13/08
摘要： A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
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5.发明授权Method for producing L-amino acids using bacteria of the enterobacteriaceae family 有权使用肠杆菌科的细菌生产L-氨基酸的方法公开(公告)号：US08785161B2
公开(公告)日：2014-07-22
申请号：US13466266
申请日：2012-05-08
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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6.发明申请METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY 有权使用肠杆菌属细菌生产L-氨基酸的方法公开(公告)号：US20120219996A1
公开(公告)日：2012-08-30
申请号：US13466266
申请日：2012-05-08
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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7.发明授权Method for producing L-amino acids using bacteria of the Enterobacteriaceae family 有权使用肠杆菌科的细菌生产L-氨基酸的方法公开(公告)号：US07915018B2
公开(公告)日：2011-03-29
申请号：US11247138
申请日：2005-10-12
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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8.发明申请Method for Producing a Non-Aromatic L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Expression of the csrA Gene Attenuated 有权使用具有csrA基因表达的肠杆菌科的细菌产生非芳香族L-氨基酸的方法衰减公开(公告)号：US20090239266A1
公开(公告)日：2009-09-24
申请号：US11830969
申请日：2007-07-31
申请人： Andrey Yurievich Gulevich , Danila Vadimovich ZIMENKOV , Elena Vitalievna KLYACHKO , Tatyana Viktorovna LEONOVA , Yury Ivanovich Kozlov , Vitaly Grigorievich PARASKEVOV
发明人： Andrey Yurievich Gulevich , Danila Vadimovich ZIMENKOV , Elena Vitalievna KLYACHKO , Tatyana Viktorovna LEONOVA , Yury Ivanovich Kozlov , Vitaly Grigorievich PARASKEVOV
IPC分类号： C12P13/24 , C12N1/21 , C12P13/20 , C12P13/12 , C12P13/06 , C12P13/08 , C12P13/14 , C12P13/04
CPC分类号： C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/24
摘要： The present invention provides a method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the csrA gene.
摘要翻译： 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的非芳香族L-氨基酸的制造方法，其已被修饰以减弱csrA基因的表达。
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9.发明授权Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes 有权利用具有增强的木糖利用基因表达的细菌通过发酵生产L-氨基酸的方法公开(公告)号：US08003367B2
公开(公告)日：2011-08-23
申请号：US11079392
申请日：2005-03-15
申请人： Aleksey Nikolaevich Marchenko , Sergey Vladimirovich Benevolensky , Elena Vitalievna Klyachko , Yuri Ivanovich Kozlov , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner
发明人： Aleksey Nikolaevich Marchenko , Sergey Vladimirovich Benevolensky , Elena Vitalievna Klyachko , Yuri Ivanovich Kozlov , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner
摘要： A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
摘要翻译： 使用具有增加基因表达的埃希氏杆菌属的细菌，例如L-组氨酸，L-苏氨酸，L-赖氨酸，L-谷氨酸和L-色氨酸等的L-氨基酸的生产方法，例如 公开了编码木糖利用酶的xylABFGHR基因座的那些。 该方法包括在含有木糖的培养基中培养L-氨基酸生产菌，并从培养基中收集L-氨基酸。
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10.发明授权Method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family having expression of the csrA gene attenuated 有权使用具有csrA基因表达的肠杆菌科的细菌制造非芳香族L-氨基酸的方法减毒公开(公告)号：US07771976B2
公开(公告)日：2010-08-10
申请号：US11830969
申请日：2007-07-31
申请人： Andrey Yurievich Gulevich , Danila Vadimovich Zimenkov , Elena Vitalievna Klyachko , Tatyana Viktorovna Leonova , Yury Ivanovich Koslov , Vitaly Grigorievich Paraskevov, legal representative
发明人： Andrey Yurievich Gulevich , Danila Vadimovich Zimenkov , Elena Vitalievna Klyachko , Tatyana Viktorovna Leonova , Yury Ivanovich Koslov
IPC分类号： C12P13/08 , C12P13/04 , C12P13/24 , C12P13/20 , C12P13/14 , C12P13/12 , C12P13/06 , C12N1/20 , C07K14/00 , C07H21/02
CPC分类号： C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/24
摘要： The present invention provides a method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the csrA gene.
摘要翻译： 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的非芳香族L-氨基酸的制造方法，其已被修饰以减弱csrA基因的表达。
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