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1.发明申请Method for producing L-amino acids using bacteria belonging to the genus escherichia 有权使用属于埃希氏菌属的细菌生产L-氨基酸的方法公开(公告)号：US20100099153A1
公开(公告)日：2010-04-22
申请号：US12569335
申请日：2009-09-29
申请人： Maria Viacheslavovna Vitushkina , Vitaliy Arkadyevich Livshits , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Irina Vladimirovna Biryukova , Zhanna Iosifovna Katashkina , Aleksandra Yurievna Skorokhodova , Alla Valentinovna Belareva
发明人： Maria Viacheslavovna Vitushkina , Vitaliy Arkadyevich Livshits , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Irina Vladimirovna Biryukova , Zhanna Iosifovna Katashkina , Aleksandra Yurievna Skorokhodova , Alla Valentinovna Belareva
IPC分类号： C12P13/22
CPC分类号： C12P13/222 , C07K14/245 , C12P13/227 , C12P21/02
摘要： A method for producing lower alkyl ester of α-L-aspartyl-L-phenylalanine by cultivating a recombinant Escherichia coli bacterium that has the ability to produce and accumulate an aromatic L-amino acid according in a culture medium to produce and accumulate L-phenylalanine in the medium and synthesizing lower alkyl ester of α-L-aspartyl-L-phenylalanine from the aspartic acid or its derivative and the obtained L-phenylalanine.
摘要翻译： 通过培养能够在培养基中产生并积累芳香族L-氨基酸的重组大肠杆菌细菌来生产和积累L-苯丙氨酸的生产α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯的方法 在培养基中合成α-L-天冬氨酰-L-苯丙氨酸的低级烷基酯，得到L-苯丙氨酸。
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2.发明授权Escherichia bacteria transformed with the yddG gene to enhance L-amino acid producing activity 有权用yddG基因转化的大肠杆菌细菌以增强L-氨基酸产生活性公开(公告)号：US07666655B2
公开(公告)日：2010-02-23
申请号：US10302997
申请日：2002-11-25
申请人： Maria Viacheslavovna Vitushkina , Vitaliy Arkadyevich Livshits , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Irina Vladimirovna Biryukova , Zhanna Iosifovna Katashkina , Aleksandra Yurievna Skorokhodova , Alla Valentinovna Belareva
发明人： Maria Viacheslavovna Vitushkina , Vitaliy Arkadyevich Livshits , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Irina Vladimirovna Biryukova , Zhanna Iosifovna Katashkina , Aleksandra Yurievna Skorokhodova , Alla Valentinovna Belareva
CPC分类号： C12P13/222 , C07K14/245 , C12P13/227 , C12P21/02
摘要： The present invention relates to a method for producing L-amino acid, such as L-phenylalanine and L-tryptophan, is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yddG gene from Escherichia coli, wherein said protein has an activity to make said bacterium resistant to L-phenylalanine, a phenylalanine analogue, or a tryptophan analogue. The present invention further relates to a method for producing lower alkyl ester of α-L-aspartyl-L-phenylalanine.
摘要翻译： 本发明涉及使用属于埃希氏杆菌属的细菌的L-苯丙氨酸和L-色氨酸的L-氨基酸的生产方法，其中所述细菌的L-氨基酸生产力通过提高所述细菌的活性而提高 由来自大肠杆菌的yddG基因编码的蛋白质，其中所述蛋白质具有使所述细菌对L-苯丙氨酸，苯丙氨酸类似物或色氨酸类似物具有抗性的活性。 本发明还涉及α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯的制造方法。
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公开(公告)号：US07989611B2
公开(公告)日：2011-08-02
申请号：US11002141
申请日：2004-12-03
CPC分类号： C12N15/71
摘要： An expression control sequence which controls expression of a target gene linked downstream of the expression control sequence depending on an intracellular concentration of an amino acid, wherein in a bacterial cell which harbors a DNA construct comprising the expression control sequence, a promoter linked upstream of the expression control sequence and the target gene linked downstream of the expression control sequence, frequency of termination in the expression control sequence, of transcription starting from the promoter is lowered by increase of an intracellular concentration of an amino acid, whereby expression of the target gene increases.
摘要翻译： 根据氨基酸的细胞内浓度控制表达控制序列下游的靶基因的表达的表达调控序列，其中在含有表达控制序列的DNA构建体的细菌细胞中，连接上游的启动子 通过增加氨基酸的细胞内浓度来降低表达控制序列和连接于表达控制序列下游的靶基因，表达控制序列中的终止频率，起始于启动子的转录，从而靶基因的表达增加 。
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4.发明授权Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine 有权制备α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯的方法公开(公告)号：US07935506B2
公开(公告)日：2011-05-03
申请号：US12569335
申请日：2009-09-29
申请人： Maria Viacheslavovna Vitushkina , Vitaliy Arkadyevich Livshits , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Irina Vladimirovna Biryukova , Zhanna Iosifovna Katashkina , Aleksandra Yurievna Skorokhodova , Alla Valentinovna Belareva
发明人： Maria Viacheslavovna Vitushkina , Vitaliy Arkadyevich Livshits , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Irina Vladimirovna Biryukova , Zhanna Iosifovna Katashkina , Aleksandra Yurievna Skorokhodova , Alla Valentinovna Belareva
IPC分类号： C12P13/22
CPC分类号： C12P13/222 , C07K14/245 , C12P13/227 , C12P21/02
摘要： A method for producing lower alkyl ester of α-L-aspartyl-L-phenylalanine by cultivating a recombinant Escherichia coli bacterium that has the ability to produce and accumulate an aromatic L-amino acid according in a culture medium to produce and accumulate L-phenylalanine in the medium and synthesizing lower alkyl ester of α-L-aspartyl-L-phenylalanine from the aspartic acid or its derivative and the obtained L-phenylalanine.
摘要翻译： 通过培养能够在培养基中产生并积累芳香族L-氨基酸的重组大肠杆菌细菌来生产和积累L-苯丙氨酸的生产α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯的方法 在培养基中合成α-L-天冬氨酰-L-苯丙氨酸的低级烷基酯，得到L-苯丙氨酸。
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5.发明授权Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the ydiN gene or the ydiB gene or combination thereof 有权使用具有减弱的ydiN基因或ydiB基因表达的肠杆菌科的细菌生产L-氨基酸的方法或其组合公开(公告)号：US07820415B2
公开(公告)日：2010-10-26
申请号：US12372060
申请日：2009-02-17
申请人： Andrey Yurievich Gulevich , Tatyana Aleksandrovna Gaydenko , Vladimir Yurievich Ermishev , Aleksandra Yurievna Skorokhodova , Irina Vladimirovna Biryukova , Sergei Vladimirovich Mashko
发明人： Andrey Yurievich Gulevich , Tatyana Aleksandrovna Gaydenko , Vladimir Yurievich Ermishev , Aleksandra Yurievna Skorokhodova , Irina Vladimirovna Biryukova , Sergei Vladimirovich Mashko
CPC分类号： C12P13/222 , C07K14/245 , C12N9/0006 , C12P13/225 , C12P13/227 , C12P21/02
摘要： The present invention provides a method for producing an aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ydiN gene, the ydiB gene, or both.
摘要翻译： 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌生产芳香族L-氨基酸的方法，其已经被修饰以减弱ydiN基因，ydiB基因或两者的表达 。
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6.发明申请公开(公告)号：US20090226919A1
公开(公告)日：2009-09-10
申请号：US12388568
申请日：2009-02-19
申请人： Andrey Yurievich Gulevich , Aleksandra Yurievna Skorokhodova , Vladimir Yurievich Ermishev , Natalya Igorevna Minaeva , Danila Vadimovich Zimenkov , Aleksandr Aleksandrovich Krylov , Irina Vladimirovna Biryukova , Sergei Vladimirovich Mashko
发明人： Andrey Yurievich Gulevich , Aleksandra Yurievna Skorokhodova , Vladimir Yurievich Ermishev , Natalya Igorevna Minaeva , Danila Vadimovich Zimenkov , Aleksandr Aleksandrovich Krylov , Irina Vladimirovna Biryukova , Sergei Vladimirovich Mashko
IPC分类号： C12Q1/68 , C12N1/21 , C12P21/00 , C12N9/00 , C12P13/04 , C12P19/38 , C12P19/30 , C12P1/04 , C12N15/64 , C12N15/66
CPC分类号： C12N15/70
摘要： The present invention provides a method for constructing recombinant translationally coupled operons, a method for producing useful metabolites using the bacterium containing the coupled operons, and a method for monitoring gene expression.
摘要翻译： 本发明提供构建重组翻译偶联的操纵子的方法，使用含有偶联的操纵子的细菌产生有用的代谢物的方法，以及监测基因表达的方法。
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7.发明授权Method of producing amino acids using E. coli transformed with sucrose PTS genes 有权使用用蔗糖PTS基因转化的大肠杆菌生产氨基酸的方法公开(公告)号：US07179623B2
公开(公告)日：2007-02-20
申请号：US11204011
申请日：2005-08-16
申请人： Vitaliy Arkadyevich Livshits , Vera Georgievna Doroshenko , Sergei Vladimirovich Mashko , Valery Zavenovich Akhverdian , Yury Ivanovich Kozlov
发明人： Vitaliy Arkadyevich Livshits , Vera Georgievna Doroshenko , Sergei Vladimirovich Mashko , Valery Zavenovich Akhverdian , Yury Ivanovich Kozlov
CPC分类号： C12N9/1205 , C12N15/52 , C12P13/04
摘要： Amino acids such as threonine, homoserine, isoleucine, lysine, valine and tryptophan are produced using a bacterium belonging to the genus Escherichia which has been constructed from a sucrose non-assimilative strain belonging to the genus Escherichia and which harbors sucrose non-PTS or PTS genes and has an ability to produce the amino acid.
摘要翻译： 氨基酸如苏氨酸，高丝氨酸，异亮氨酸，赖氨酸，缬氨酸和色氨酸使用属于埃希氏杆菌属的细菌产生，该细菌由属于埃希氏杆菌属的蔗糖非同化菌株构建，并含有蔗糖非PTS或PTS 基因并具有产生氨基酸的能力。
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公开(公告)号：US08728774B2
公开(公告)日：2014-05-20
申请号：US13032057
申请日：2011-02-22
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
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9.发明申请METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY 有权使用肠杆菌属细菌生产L-氨基酸的方法公开(公告)号：US20110143403A1
公开(公告)日：2011-06-16
申请号：US13032057
申请日：2011-02-22
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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10.发明授权Method for producing L-amino acids using bacteria of the enterobacteriaceae family 有权使用肠杆菌科的细菌生产L-氨基酸的方法公开(公告)号：US08785161B2
公开(公告)日：2014-07-22
申请号：US13466266
申请日：2012-05-08
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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