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1.发明申请公开(公告)号：US20080199480A1
公开(公告)日：2008-08-21
申请号：US11572420
申请日：2004-07-22
Applicant: Maria L. Langdown , Matthew R. Nelson , Rikard H. Reneland , Stefan M. Kammerer , Andreas Braun , Mikhail F. Denissenko , Josephine M. Atienza , Eddine Saiah , James W. Zapf
Inventor： Maria L. Langdown , Matthew R. Nelson , Rikard H. Reneland , Stefan M. Kammerer , Andreas Braun , Mikhail F. Denissenko , Josephine M. Atienza , Eddine Saiah , James W. Zapf
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Provided herein are methods for identifying a risk of type II diabetes in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating type II diabetes, and therapeutic and preventative methods applicable to type II diabetes. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.
Abstract translation: 本文提供用于鉴定受试者的II型糖尿病的风险的方法，用于实施该方法的试剂和试剂盒，用于鉴定用于治疗II型糖尿病的候选治疗剂的方法，以及适用于II型糖尿病的治疗和预防方法。 这些实施方案基于对人类基因组内核苷酸序列的多态变异的分析。
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公开(公告)号：US20080004325A1
公开(公告)日：2008-01-03
申请号：US11824007
申请日：2007-06-29
Applicant: Jinbo Lee , Zhao-Kui Wan , Douglas P. Wilson , Eva Binnun , David V. Erbe , Eddine Saiah
Inventor： Jinbo Lee , Zhao-Kui Wan , Douglas P. Wilson , Eva Binnun , David V. Erbe , Eddine Saiah
IPC: A61K31/433 , C07D417/04
CPC classification number: C07D417/04
Abstract: This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1b (PTP1b).
Abstract translation: 本发明涉及调节（例如抑制）蛋白酪氨酸磷酸酶1b（PTP1b）。
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公开(公告)号：US20070219198A1
公开(公告)日：2007-09-20
申请号：US11703522
申请日：2007-02-07
Applicant: Jason Xiang , Eddine Saiah , Steve Tam , John Mckew , Lihren Chen , Manus Ipek , Katherine Lee , Huan-Qiu Li , Jianchang Li , Wei Li , Tarek Mansour , Vipin Suri , Richard Vargas , Yuchuan Wu , Zhao-Kui Wan , Jinbo Lee , Eva Binnun , Douglas Wilson
Inventor： Jason Xiang , Eddine Saiah , Steve Tam , John Mckew , Lihren Chen , Manus Ipek , Katherine Lee , Huan-Qiu Li , Jianchang Li , Wei Li , Tarek Mansour , Vipin Suri , Richard Vargas , Yuchuan Wu , Zhao-Kui Wan , Jinbo Lee , Eva Binnun , Douglas Wilson
IPC: A61K31/5377 , A61K31/497 , A61K31/496 , C07D413/02 , C07D403/02 , C07D409/02
CPC classification number: C07D211/96 , C07D295/26 , C07D401/04 , C07D403/02 , C07D409/02 , C07D413/02
Abstract: This invention relates to inhibiting 11βHSD1.
Abstract translation: 本发明涉及抑制11betaHSD1。
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公开(公告)号：US20100093734A1
公开(公告)日：2010-04-15
申请号：US12637712
申请日：2009-12-14
Applicant: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
Inventor： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC: A61K31/5375 , C07D295/14
CPC classification number: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
Abstract: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
Abstract translation: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号：US20070088163A1
公开(公告)日：2007-04-19
申请号：US10571031
申请日：2004-09-10
Applicant: Kent Pryor , Eddine Saiah , Jeffrey Kahl , Nancy Delaet , Edward Roberts , Jan Urban , Lubomir Sebo , Christopher Lum , Hiroshi Nakanishi
Inventor： Kent Pryor , Eddine Saiah , Jeffrey Kahl , Nancy Delaet , Edward Roberts , Jan Urban , Lubomir Sebo , Christopher Lum , Hiroshi Nakanishi
IPC: C07D471/02 , C07D215/16
CPC classification number: C07D471/04 , C07D405/12
Abstract: In various aspects, the present invention relates to novel compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone disease such as osteoporosis, Paget's disease, hypercalcemia, and in the treatment of metabolic diseases, such as insulin-requiring states.
Abstract translation: 在各个方面，本发明涉及调节降钙素和胰岛淀粉样多肽受体活性的新化合物; 制备这些化合物的方法; 以及包含这些化合物的药物组合物。 本发明的化合物可用作降钙素和/或胰岛淀粉样多肽激动剂和治疗骨疾病如骨质疏松症，佩吉特氏病，高钙血症，以及治疗代谢疾病如胰岛素需求状态。
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Patent Agency Ranking
公开(公告)号：US20050107399A1
公开(公告)日：2005-05-19
申请号：US10939324
申请日：2004-09-10
Applicant: Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
Inventor： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC: A61K31/416 , A61K31/4965 , C07D20060101 , C07D403/12
CPC classification number: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
Abstract: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
Abstract translation: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号：US06825208B2
公开(公告)日：2004-11-30
申请号：US10223860
申请日：2002-08-20
Applicant: Jinglan Zhou , Leslie Robinson , Nikolaus M. Gubernator , Eddine Saiah , Xu Bai , Xin Gu
Inventor： Jinglan Zhou , Leslie Robinson , Nikolaus M. Gubernator , Eddine Saiah , Xu Bai , Xin Gu
IPC: A61K31473
CPC classification number: C07D221/18
Abstract: This invention relates generally to tetracyclic tetrahydroquinoline compounds, and analogues thereof, and pharmaceutically acceptable salt forms thereof, which are selective inhibitors of serine protease enzymes, especially factor VIIa; pharmaceutical compositions containing the same; and methods of using the same as anticoagulant agents for modulation of the coagulation cascade.
Abstract translation: 本发明一般涉及四环四氢喹啉化合物及其类似物及其药学上可接受的盐形式，其是丝氨酸蛋白酶，特别是因子VIIa的选择性抑制剂; 含有该组合物的药物组合物; 以及使用其作为抗凝血剂调节凝血级联的方法。
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公开(公告)号：US20110105509A1
公开(公告)日：2011-05-05
申请号：US12938479
申请日：2010-11-03
Applicant: Neelu Kaila , Eddine Saiah , Bruce Christopher Follows , Adrian Huang , Kristin Marie Janz , Michael Dennis Lowe , Alessandro Fabio Moretto , Jennifer Romanic Thomason , Tarek Suhayl Mansour , Cara Margaret May Williams
Inventor： Neelu Kaila , Eddine Saiah , Bruce Christopher Follows , Adrian Huang , Kristin Marie Janz , Michael Dennis Lowe , Alessandro Fabio Moretto , Jennifer Romanic Thomason , Tarek Suhayl Mansour , Cara Margaret May Williams
IPC: A61K31/502 , C07D403/04 , A61K31/501 , C07D401/06 , A61K31/4439 , C07D403/14 , C07D403/06 , A61K31/4725 , C07D417/14 , C07D401/14 , A61P11/00 , A61P1/00 , A61P17/00 , A61P29/00 , A61P37/06 , A61P37/08 , C12N5/02
CPC classification number: C07D403/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D417/14
Abstract: Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.
Abstract translation: 公开了式（I）的化合物：其可用作CRTH2受体的拮抗剂。 还公开了含有式（I）化合物和式（I）化合物用于治疗对抑制内源性配体与CRTH2受体的结合有反应的疾病或病症的药物组合物。 进一步描述制备和使用这些化合物的方法。
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公开(公告)号：US20100273797A1
公开(公告)日：2010-10-28
申请号：US12829701
申请日：2010-07-02
Applicant: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
Inventor： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC: A61K31/5377 , A61K31/5375 , A61K31/437 , A61P9/00 , A61P19/02 , A61P1/00 , A61P29/00 , A61P37/06 , A61P25/00 , A61P25/28 , A61P3/04 , A61P17/00
CPC classification number: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
Abstract: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.
Abstract translation: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。
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公开(公告)号：US07632838B2
公开(公告)日：2009-12-15
申请号：US11703522
申请日：2007-02-07
Applicant: Jason Shaoyun Xiang , Eddine Saiah , Steve Y. Tam , John C. Mckew , Lihren Chen , Manus Ipek , Huan-Qiu Li , Jianchang Li , Wei Li , Tarek Suhayl Mansour , Vipin Suri , Yuchuan Wu , Zhao-Kui Wan , Jinbo Lee , Eva Binnun , Douglas P. Wilson
Inventor： Jason Shaoyun Xiang , Eddine Saiah , Steve Y. Tam , John C. Mckew , Lihren Chen , Manus Ipek , Huan-Qiu Li , Jianchang Li , Wei Li , Tarek Suhayl Mansour , Vipin Suri , Yuchuan Wu , Zhao-Kui Wan , Jinbo Lee , Eva Binnun , Douglas P. Wilson
IPC: A61K31/4965 , C07D241/04 , C07D295/00
CPC classification number: C07D211/96 , C07D295/26 , C07D401/04 , C07D403/02 , C07D409/02 , C07D413/02
Abstract: This invention relates to inhibiting 11βHSD1.
Abstract translation: 本发明涉及抑制11betaHSD1。
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