公开(公告)号：US12111205B2

公开(公告)日：2024-10-08

申请号：US17414588

申请日：2019-12-17

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SORBONNE UNIVERSITE ,  COLLEGE DE FRANCE ,  ECOLE NORMALE SUPERIEURE

发明人： Raphaël Lescanne ,  Samuel Deleglise ,  Emmanuel Flurin ,  Zaki Leghtas

IPC分类号： G01J1/00 ,  G01J1/44

CPC分类号： G01J1/44 ,  G01J2001/442

摘要： A superconducting detection device for detecting a single microwave photon, including: —a quantum system with two energy levels of which the ground state and an excited state are controllable and detectable, the quantum system being designed to allow modulable three-wave interaction; —a buffer resonator arranged to receive an incident single microwave photon; —a highly dissipative auxiliary resonator arranged to discharge a photon; and —a reading device arranged to detect the state of the two-level quantum system; the buffer resonator and the auxiliary resonator are coupled to the quantum system; and the excited state of the quantum system and the photon of the auxiliary resonator are created in response to the reception of the incident photon in the buffer resonator and to the application of parametric pumping to the device. A method for detecting a single microwave photon implemented by a device according to the invention.

公开(公告)号：US20240295476A1

公开(公告)日：2024-09-05

申请号：US18573850

申请日：2022-06-16

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NORMALE SUPERIEURE PARIS-SACLAY ,  SAFRAN ,  SAFRAN AIRCRAFT ENGINES

发明人： Julien Paul SCHNEIDER-DIE-GROSS ,  Arturo MENDOZA QUISPE ,  Stéphane ROUX

IPC分类号： G01N3/02 ,  G06N5/022

CPC分类号： G01N3/02 ,  G06N5/022

摘要： A method for characterizing a mechanical part making it possible to evaluate the residual stresses in the part, as well as a method for constructing a predictive model and a non-destructive testing method making it possible to easily test such a part, the characterizing method including the following steps: measuring geometrical information of the part in a first state, physically transforming the part between the first state and a second state, measuring geometrical information of the part in its second state, determining the displacement field between the first state and the second state of the part by a digital image correlation method and obtaining the deformation field between the first state and the second state of the part, determining the stress field in the second state of the part by a finite element simulation method.

公开(公告)号：US20240190770A1

公开(公告)日：2024-06-13

申请号：US18286613

申请日：2022-04-29

申请人： ECOCEM MATERIALS LIMITED ,  ECOLE NORMALE SUPERIEURE PARIS-SACLAY ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  Institut National des Sciences Appliquées de Toulouse ,  UNIVERSITE PAUL SABATIER TOULOUSE III

发明人： Erisa MYRTJA ,  Artur KIIASHKO KIIASHKO ,  Laurent FROUIN ,  Martin CYR ,  Mohend CHAOUCHE

IPC分类号： C04B28/08 ,  C04B40/06

CPC分类号： C04B28/08 ,  C04B40/0625 ,  C04B2201/50

摘要： A binder composition in dry weight percentage comprises a) between 1% and 30% of at least one lime source, b) between 5% and 75% of ground granulated blast furnace slag, (c) between 20% and 90% of at least one filler, (d) between 0.1% and 5% of SO3−, e) between 0.1% and 1% of at least one water reducer polymer, f) between 0% and 2%, relative to the total weight of components a, b and c, of at least one activator different from d, the weights of d, e, f relative to the total weight of components a, b, c, said ground granulated blast furnace slag and the filler each being a mixture of two differently sized particles, the different sizes based on d50 and range of between 1 μm and 5 μm and >5 μm for the slag and between 0.05 μm and

公开(公告)号：US20240132547A1

公开(公告)日：2024-04-25

申请号：US18130375

申请日：2023-04-02

申请人： Institut National De La Sante Et De La Recherche Medicale (INSERM) ,  Centre National De La Recherche Scientifique (CNRS) ,  Ecole Normale Superieure De Lyon ,  Universite Claude Bernard Lyon 1

发明人： Théophile OHLMANN ,  Philippe MANGEOT ,  Emiliano RICCI

IPC分类号： C07K14/005 ,  C12N7/00 ,  C12N9/22 ,  C12N15/10 ,  C12N15/113

CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N9/22 ,  C12N15/102 ,  C12N15/113 ,  C07K2319/00 ,  C07K2319/43 ,  C07K2319/50 ,  C12N2310/20 ,  C12N2740/10023 ,  C12N2740/10042 ,  C12N2740/13023 ,  C12N2740/13042 ,  C12N2800/80

摘要： The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.

公开(公告)号：US20240054381A1

公开(公告)日：2024-02-15

申请号：US18268238

申请日：2021-12-16

申请人： UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE NORMALE SUPERIEURE DE LYON

发明人： Théau PERONNIN ,  Benjamin HUARD ,  Sébastien JEZOUIN ,  Antoine MARQUET

IPC分类号： G06N10/40 ,  G06N10/70

CPC分类号： G06N10/40 ,  G06N10/70

摘要： Control system (1) for a state of a quantum harmonic oscillator, comprising:—a harmonic oscillator (3) in a Schrodinger's cat type state,—a stabilisation device (10) with a predetermined parity of a number of bosons of the state, which device is configured to use first and second frequency combs each comprising at least as many rays as a mean number of bosons in the state, and—a multiphonic dissipation device (20) which is suitable for removing at least one pair of bosons simultaneously from the oscillator, the dissipation device being activated only between two successive time peaks of the frequency combs over a time period greater than the inverse of the product of the mean number and the inverse of the characteristic time of the multiphonic dissipation, a time period separating two activation periods being less than a characteristic loss time of a boson.

公开(公告)号：US20240024861A1

公开(公告)日：2024-01-25

申请号：US18030383

申请日：2021-10-05

申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) ,  UNIVERSITAT POLITECNICA DE VALENCIA ,  PARIS SCIENCES ET LETTRES ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  CENTRE NATIONA DE LA RECHRCHE SCIENTIFIQUE ,  ECOLE NORMALE SUPERIEURE

发明人： Sergio NAVALÓN OLTRA ,  Christina VALLES GARCIA ,  Maria CABRERO ANTONINO ,  Hermeagildo GARCIA GOMEZ ,  Christian SERRE ,  Georges MOUCHAHAM ,  Lin ZHOU

IPC分类号： B01J31/16 ,  B01J35/00 ,  C01B3/04

CPC分类号： B01J31/1691 ,  B01J35/004 ,  B01J35/0006 ,  C01B3/042 ,  C01B2203/1052 ,  C01B2203/1076

摘要： The present invention relates to metal-organic frameworks (MOFs) which contain trimetallic centres with pyrazole as a ligand in the structure thereof. Particularly, it relates to MOFs which contain units of formula (I). The present invention also relates to a photocatalytic method for generating H2 starting from liquid water or vapour using said materials.

公开(公告)号：US11803014B2

公开(公告)日：2023-10-31

申请号：US17759532

申请日：2021-01-29

申请人： SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE NORMALE SUPERIEURE

发明人： Jakob Reichel ,  Romain Long

IPC分类号： G02B6/25 ,  G02B6/293 ,  G02B6/38 ,  G02F1/21 ,  G02B6/26

CPC分类号： G02B6/29359 ,  G02B6/25 ,  G02B6/29398 ,  G02B6/3801 ,  G02F1/213 ,  G02B6/262

摘要： Optical system comprising two optical fibres which are configured to define between them a Fabry-Perot cavity, and a connecting element bonded to each of the two optical fibres, the connecting element defining a through-passage, at least one of the two optical fibres comprising an end portion arranged in the through-passage and bonded to the connecting element, the two optical fibres extending along an axis and being separated from one another by a distance Le parallel to the axis, one of the optical fibres being bonded to the connecting element at a first bonding zone, and the other optical fibre being bonded to the connecting element at a second bonding zone separated from the first bonding zone by distance parallel to the axis.

公开(公告)号：US20230278983A1

公开(公告)日：2023-09-07

申请号：US18004380

申请日：2021-07-06

申请人： Universite Claude Bernard Lyon 1 ,  Institut National de la Sante et de la Recherche Madicale ,  Centre National de la Recherche Scientifique ,  Ecole Normale Superieure de Lyon ,  Commissariat à l'Energie Atomique et aux Energies Alternatives ,  Centre Leon Berard

发明人： Alexandre Bancet ,  Claude Cochet ,  Odile Filhol-Cochet ,  Isabelle Krimm ,  Thierry Lomberget ,  Marc Le Borgne

IPC分类号： C07D401/14 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  A61P35/00

CPC分类号： C07D401/14 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  A61P35/00

摘要： The present invention relates to indole derivatives of formula (I′) as CK2 inhibitor and pharmaceutical compositions comprising the same. The present invention further relates to the use of such compounds of formula (I) for use for preventing and/or treating a cancer.

公开(公告)号：US20230141123A1

公开(公告)日：2023-05-11

申请号：US17768463

申请日：2020-07-31

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NORMALE SUPERIEURE DE PARIS ,  SORBONNE UNIVERSITE

发明人： Raja CHOUKET ,  Agathe ESPAGNE ,  Ludovic JULLIEN ,  Annie LEMARCHAND ,  Thomas LE SAUX ,  Agnès PELLISSIER-TANON ,  Laurence SIGNON COLONNA BOZZI ,  Ruikang ZHANG

IPC分类号： G01N21/64 ,  G01N21/65 ,  G02B21/08 ,  G02B27/14 ,  G02B21/16

CPC分类号： G01N21/6458 ,  G01N21/65 ,  G02B21/08 ,  G02B27/141 ,  G02B21/16 ,  G01N2021/6419

摘要： An apparatus for performing photochemical measurements on a liquid or liquid-containing sample includes a light generating system, an optical system configured for directing light from the light generating system towards the sample and a sensing system for measuring at least one optical property of the sample, wherein the light generating system is configured for generating light with intensity levels adjustable within a range, spanning at least three and preferably at least five orders of magnitude; and in that the optical system is configured for directing light from the light generating system towards the sample so as to generate a substantially uniform light intensity level, within a cylindrical region of the sample having a height larger than or equal to five time its radius.

公开(公告)号：US20230057033A1

公开(公告)日：2023-02-23

申请号：US17780855

申请日：2020-11-30

申请人： MOLSID ,  ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS

发明人： Jens HASSERODT ,  Mathieu BORDY ,  Quentin GLENADEL ,  Charlie VERRIER

IPC分类号： G01N33/542 ,  G01N33/58 ,  C07D477/24 ,  C07D501/34 ,  C09B57/00 ,  C09B67/44

摘要： Probes for the detection of β-lactamase-type enzymatic activity. In particular, novel fluorogenic substrates for detecting the presence of a catalytically active β-lactamase and a detection method using such substrates.