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公开(公告)号：US08292944B2
公开(公告)日：2012-10-23
申请号：US11016269
申请日：2004-12-17
申请人： Eric V. Schmid , John D. Nguyen , Steven C. Howard , Orlando M. Padilla , Andrew Morris , Robert F. Eisele , Joseph Anthony DiPari , David G. Matsuura , Philip J. Simpson , Walter D. Gillespie , Daniel Moore , Thomas R. Jackson , Joan Zeltinger , Keith Allen Esser , Donald K. Brandom
发明人： Eric V. Schmid , John D. Nguyen , Steven C. Howard , Orlando M. Padilla , Andrew Morris , Robert F. Eisele , Joseph Anthony DiPari , David G. Matsuura , Philip J. Simpson , Walter D. Gillespie , Daniel Moore , Thomas R. Jackson , Joan Zeltinger , Keith Allen Esser , Donald K. Brandom
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/92 , A61F2/93 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , B33Y80/00
摘要： The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.
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公开(公告)号：US08133959B2
公开(公告)日：2012-03-13
申请号：US13101499
申请日：2011-05-05
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
摘要翻译： 固有的不透射线的侧链可结晶聚合物（IRSCCP）可用于各种医疗应用。 IRSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物，重原子以有效使聚合物不透射线的量存在。 包括IRSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。
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公开(公告)号：US07473417B2
公开(公告)日：2009-01-06
申请号：US11200656
申请日：2005-08-10
申请人： Joan Zeltinger , Donald K. Brandom
发明人： Joan Zeltinger , Donald K. Brandom
CPC分类号： C08G65/4006 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91591 , A61F2210/0004 , A61K49/0442 , A61L31/18 , B33Y70/00 , B33Y80/00 , C08G64/08 , C08G64/18
摘要： Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresorbable and radiopaque and physicomechanical properties are desired.
摘要翻译： 本发明的优选实施方案涉及聚合物医疗装置，例如支架。 更具体地，本文公开的组合物包含含卤素的苯酚，其可用于医疗器械和其它需要生物可再吸收和不透射线和物理机械性能的用途。
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公开(公告)号：US20110213456A1
公开(公告)日：2011-09-01
申请号：US13101391
申请日：2011-05-05
IPC分类号： A61F2/82 , C08F220/18 , C08F8/14
CPC分类号： A61L31/18 , A61F2/92 , A61K49/12 , A61K49/126 , A61K49/128 , A61L31/06 , C08F220/00 , C08G63/00 , C08G63/08
摘要： Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.
摘要翻译： 侧链可结晶（SCC）聚合物可用于各种医疗应用。 在某些应用中，含重链原子的侧链可结晶聚合物（HACSCCP）特别有用。 HACSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物。 在某些构型中，重质原子以有效使聚合物不透射线的量存在。 包括HACSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。 包括SCC聚合物的聚合物材料也可制成其他医疗装置，例如支架。
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公开(公告)号：US20130253631A1
公开(公告)日：2013-09-26
申请号：US13615339
申请日：2012-09-13
申请人： Eric V. Schmid , John D. Nguyen , Steven C. Howard , Orlando M. Padilla , Andrew Morris , Robert F. Eisele , Joseph Anthony DiPari , David G. Matsuura , Philip J. Simpson , Walter D. Gillespie , Daniel Moore , Thomas R. Jackson , Joan Zeltinger , Keith Allen Esser , Donald K. Brandom
发明人： Eric V. Schmid , John D. Nguyen , Steven C. Howard , Orlando M. Padilla , Andrew Morris , Robert F. Eisele , Joseph Anthony DiPari , David G. Matsuura , Philip J. Simpson , Walter D. Gillespie , Daniel Moore , Thomas R. Jackson , Joan Zeltinger , Keith Allen Esser , Donald K. Brandom
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/92 , A61F2/93 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , B33Y80/00
摘要： The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.
摘要翻译： 本发明涉及一种包括周向相邻模块的可扩张支架。 模块包括纵向相邻的滑动和锁定径向元件，其允许径向元件从塌缩直径单向滑动到扩张/展开的直径，但是抑制从扩张直径的径向反冲。
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公开(公告)号：US20100131037A1
公开(公告)日：2010-05-27
申请号：US12566623
申请日：2009-09-24
申请人： Joachim B. Kohn , Durgadas Bolikal , Aaron D. Pesnell , Joan Zeltinger , Donald K. Brandom , Eric Schmid
发明人： Joachim B. Kohn , Durgadas Bolikal , Aaron D. Pesnell , Joan Zeltinger , Donald K. Brandom , Eric Schmid
CPC分类号： A61L31/148 , A61F2/82 , A61F2250/0098 , A61L31/06 , A61L31/18 , C08L71/02
摘要： The present invention relates to polymeric medical devices such as stents. More particularly the polymeric compositions disclosed herein comprise halogen-containing, tyrosine-derived diphenols, optionally in conjunction with other groups, such as dicarboxylic acids and/or poly(alkylene oxides), such that the medical devices made from these polymeric compositions are bioresorbable and inherently radiopaque, and exhibit physicomechanical properties consistent with the intended uses of such devices.
摘要翻译： 本发明涉及诸如支架的聚合物医疗装置。 更具体地，本文公开的聚合物组合物包含含卤素的酪氨酸衍生的二酚，任选地与其它基团如二羧酸和/或聚（环氧烷烃）结合，使得由这些聚合物组合物制成的医疗装置是生物可再吸收的， 固有地不透射线，并表现出与这种装置的预期用途一致的物理机械性质。
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公开(公告)号：US5547996A
公开(公告)日：1996-08-20
申请号：US282029
申请日：1994-07-29
CPC分类号： C08J9/02 , C08G61/127 , C08L71/00 , C08L79/08 , C08J2361/20
摘要： Reacting carbonyls, such as aldehydes and ketones, with amines produces a ketimine or aldimine and a water byproduct. When the ketimine or aldimine reaction occurs in a polymer composition, the polymer becomes foamed due to the evolution of water. Hence, carbonyl and amine containing compounds may be introduced into a polymeric composition to serve as an in-situ blowing agent. The carbonyl and amine containing compounds may be different polymers which will be combined through a ketimine or aldimine linkage to form a graft co-polymer, they may be small molecular weight additives that are placed in the composition with a polymer that is to be foamed as a byproduct of a ketimine or aldimine reaction of the additives, or they may be a polymer containing a carbonyl or amine moiety and a small molecular weight additive compound that will react with the moiety on the polymer to form a ketimine or aldimine.
摘要翻译： 羰基化合物如醛和酮与胺反应产生酮亚胺或醛亚胺和水副产物。 当在聚合物组合物中发生酮亚胺或醛亚胺反应时，由于水的释放，聚合物变得发泡。 因此，可以将羰基和胺化合物引入聚合物组合物中以用作原位发泡剂。 含羰基和胺的化合物可以是不同的聚合物，它们将通过酮亚胺或醛亚胺键组合以形成接枝共聚物，它们可以是小分子量的添加剂，其被放置在组合物中，其中待发泡的聚合物为 或者它们可以是含有羰基或胺部分和小分子量添加剂化合物的聚合物，其将与聚合物上的部分反应以形成酮亚胺或醛亚胺。
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公开(公告)号：US09782523B2
公开(公告)日：2017-10-10
申请号：US13101391
申请日：2011-05-05
CPC分类号： A61L31/18 , A61F2/92 , A61K49/12 , A61K49/126 , A61K49/128 , A61L31/06 , C08F220/00 , C08G63/00 , C08G63/08
摘要： Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.
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公开(公告)号：US08703113B2
公开(公告)日：2014-04-22
申请号：US11335771
申请日：2006-01-18
IPC分类号： A61K31/74
CPC分类号： A61L31/18 , A61F2/92 , A61K49/12 , A61K49/126 , A61K49/128 , A61L31/06 , C08F220/00 , C08G63/00 , C08G63/08
摘要： Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.
摘要翻译： 侧链可结晶（SCC）聚合物可用于各种医疗应用。 在某些应用中，含重链原子的侧链可结晶聚合物（HACSCCP）特别有用。 HACSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物。 在某些构型中，重质原子以有效使聚合物不透射线的量存在。 包括HACSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。 包括SCC聚合物的聚合物材料也可制成其他医疗装置，例如支架。
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公开(公告)号：US08685367B2
公开(公告)日：2014-04-01
申请号：US10952274
申请日：2004-09-27
CPC分类号： A61K31/785 , A61K49/0442
摘要： Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
摘要翻译： 优选的实施方案涉及固有的不透射线的，生物相容的，生物可再吸收的聚合物颗粒的组合物和使用它们来栓塞体腔的方法。
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