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公开(公告)号：US07803603B2
公开(公告)日：2010-09-28
申请号：US12061050
申请日：2008-04-02
CPC分类号： C07K14/4354 , G01N33/573 , G01N2500/04
摘要： Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
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公开(公告)号：US07659369B2
公开(公告)日：2010-02-09
申请号：US11834237
申请日：2007-08-06
IPC分类号： C07K14/00
CPC分类号： C07K14/4354 , G01N33/573 , G01N2500/04
摘要： Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码ATP合酶亚基E多肽的线虫的核酸分子。 还提供了ATP合酶亚基E样多肽序列，载体，宿主细胞和用于产生ATP合酶亚基E样核苷酸和多肽的重组方法。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07479384B2
公开(公告)日：2009-01-20
申请号：US10819645
申请日：2004-04-06
IPC分类号： C12N9/04 , C12N15/00 , C12N1/20 , C12Q1/26 , C12P21/04 , A01N25/00 , C07H21/04 , C12Q1/00 , C12Q1/68
CPC分类号： C12N9/0006
摘要： Disclosed are two nucleic acid molecules from M. incognita encoding malate dehydrogenase-like (MDH-like) polypeptides. The MDH-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of MDH-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 公开了来自编码苹果酸脱氢酶样（MDH样）多肽的不加共轭体的两个核酸分子。 还提供MDH样多肽序列，载体，宿主细胞以及用于产生MDH样核苷酸和多肽的重组方法。 本发明还涉及用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US06818433B1
公开(公告)日：2004-11-16
申请号：US10082894
申请日：2002-02-26
IPC分类号： C12N912
CPC分类号： C12Y504/02001 , C07H21/04 , C12N9/90
摘要： Disclosed is a nucleic acid molecule from nematodes encoding for phosphoglycerate mutase (PGM) polypeptides. The PGM-like polypeptide sequence is also provided, as are vectors, host cells, and recombinant methods for production of PGM-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production. Such inhibitors are useful for control nematode infection.
摘要翻译： 公开了编码磷酸甘油酸变位酶（PGM）多肽的线虫的核酸分子。 还提供PGM样多肽序列，载体，宿主细胞以及用于产生PGM样核苷酸和多肽的重组方法。 本发明还涉及用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。 这种抑制剂可用于控制线虫感染。
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公开(公告)号：US20120030834A1
公开(公告)日：2012-02-02
申请号：US12935266
申请日：2009-04-10
申请人： John D. Bradley , Brandi Chiapelli , Bingli Gao , James P. McCarter , Michelle L. Verbsky , Deryck Jeremy Williams
发明人： John D. Bradley , Brandi Chiapelli , Bingli Gao , James P. McCarter , Michelle L. Verbsky , Deryck Jeremy Williams
IPC分类号： C12N15/82 , C12N15/63 , C12N1/00 , C12N5/10 , A01H5/00 , A01H5/10 , A01N63/02 , C12Q1/68 , C07H21/02 , C12N15/113 , C12N1/19 , C12N1/15 , A01P5/00 , C07K14/415 , C11B1/00 , C08B30/00 , A23L1/212 , A23D9/00 , C07H21/04
CPC分类号： C12N15/8285 , A01H4/008 , A01N57/16 , A01N63/02 , A01N65/00 , C07K14/4354 , C12N15/113 , C12N15/8218 , C12N15/8261 , C12N15/8273 , C12N2310/14 , Y02A40/164
摘要： The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets show significant conservation at the nucleotide level between orthologs from different Meloidogyne species, facilitating genus-wide targeting by RNA interference.
摘要翻译： 本发明公开了由根结线虫（根结线虫）的线虫引起的植物病害遗传控制的基因靶标，构建体和方法。 本发明涉及通过鉴定靶编码序列和使用重组DNA技术来实现植物保护作用，用于转录后抑制或抑制植物寄生线虫细胞中靶编码序列的表达。 所公开的基因靶标显示在来自不同的根结线虫种类的直向同源物之间的核苷酸水平上的显着的保守性，通过RNA干扰促进了属于全局的靶向。
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6.发明授权公开(公告)号：US08088976B2
公开(公告)日：2012-01-03
申请号：US11360355
申请日：2006-02-23
申请人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
发明人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开序列的细胞的方法，以及用于检测生物样品中所公开序列的方法。
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7.发明授权公开(公告)号：US08067671B2
公开(公告)日：2011-11-29
申请号：US12101830
申请日：2008-04-11
申请人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
发明人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开序列的细胞的方法，以及用于检测生物样品中所公开序列的方法。
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8.发明授权Methods for identifying compounds that bind to nematode ATP synthase subunit E polypeptide 有权鉴定结合线虫ATP合酶亚基E多肽的化合物的方法公开(公告)号：US07655418B2
公开(公告)日：2010-02-02
申请号：US11834182
申请日：2007-08-06
IPC分类号： G01N33/53
CPC分类号： C07K14/4354 , G01N33/573 , G01N2500/04
摘要： Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码ATP合酶亚基E多肽的线虫的核酸分子。 还提供了ATP合酶亚基E样多肽序列，载体，宿主细胞和用于产生ATP合酶亚基E样核苷酸和多肽的重组方法。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20080160595A1
公开(公告)日：2008-07-03
申请号：US11834237
申请日：2007-08-06
IPC分类号： C12N9/00
CPC分类号： C07K14/4354 , G01N33/573 , G01N2500/04
摘要： Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码ATP合酶亚基E多肽的线虫的核酸分子。 还提供了ATP合酶亚基E样多肽序列，载体，宿主细胞和用于产生ATP合酶亚基E样核苷酸和多肽的重组方法。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20080113388A1
公开(公告)日：2008-05-15
申请号：US11834182
申请日：2007-08-06
IPC分类号： G01N33/53
CPC分类号： C07K14/4354 , G01N33/573 , G01N2500/04
摘要： Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
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