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    METHODS FOR SYNTHESIZING LABELED COMPOUNDS
    3.
    发明申请
    METHODS FOR SYNTHESIZING LABELED COMPOUNDS 审中-公开
    合成标记化合物的方法

    公开(公告)号：US20130060017A1

    公开(公告)日：2013-03-07

    申请号：US13550055

    申请日：2012-07-16

    申请人： Dennis ESHIMA ,  Mehmet HUSNU ,  Jim STONE ,  Brian C. KELLEY

    发明人： Dennis ESHIMA ,  Mehmet HUSNU ,  Jim STONE ,  Brian C. KELLEY

    IPC分类号： C07H1/00

    CPC分类号： C07H5/02

    摘要： The invention relates to methods for synthesizing compounds on solid supports. The invention also relates to synthesizing labeled compounds, such as those used in the field of radiopharmaceuticals. The invention relates to methods for synthesizing halogenated radiopharmaceuticals such as fludeoxyglucose (also known as fluorodeoxyglucose or FDG).

    摘要翻译： 本发明涉及在固体支持物上合成化合物的方法。 本发明还涉及合成标记的化合物，例如在放射性药物领域中使用的化合物。 本发明涉及卤代放射性药物如氟脱氧葡萄糖（也称为氟脱氧葡萄糖或FDG）的合成方法。

    CLOSED VIAL FILL SYSTEM FOR ASEPTIC DISPENSING
    4.
    发明申请
    CLOSED VIAL FILL SYSTEM FOR ASEPTIC DISPENSING 有权
    封闭式盲管系统用于自由分配

    公开(公告)号：US20120222774A1

    公开(公告)日：2012-09-06

    申请号：US13339226

    申请日：2011-12-28

    申请人： Mehmet HUSNU ,  Dennis Eshima ,  Derrick Alcaide ,  Scott N. Danhof ,  Jim Gleeson ,  Eric Hassenpflug ,  Jim Prescott

    发明人： Mehmet HUSNU ,  Dennis Eshima ,  Derrick Alcaide ,  Scott N. Danhof ,  Jim Gleeson ,  Eric Hassenpflug ,  Jim Prescott

    IPC分类号： B65B1/04 ,  B65D71/06

    CPC分类号： A61J1/2006 ,  A61B50/33 ,  A61J1/1406 ,  B65B3/003 ,  B65B37/06

    摘要： A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.

    摘要翻译： 封闭路径小瓶填充系统包括散装产品小瓶，由步进电动机操作的蠕动泵，分配歧管组件，可连接至少一个最终产品小瓶，可选的质量检查站和可选的废物收集系统。 可以将浓度，活性和体积（CAV）传感器并入系统以直接从合成单元接收放射性药物产品。 控制系统可以集成到系统中以提供对放射性药物分配过程的各个方面的自动控制。 该系统用于将完成的放射性药物无菌分配到接收容器中，例如质量控制小瓶，无菌小瓶和/或最终产品小瓶，同时为用户提供去除和丢弃被污染的一次性组件的有效手段。

    CZT SENSOR FOR TUMOR DETECTION AND TREATMENT
    6.
    发明申请
    CZT SENSOR FOR TUMOR DETECTION AND TREATMENT 审中-公开
    CZT传感器用于肿瘤检测和治疗

    公开(公告)号：US20130060134A1

    公开(公告)日：2013-03-07

    申请号：US13606591

    申请日：2012-09-07

    申请人： Dennis ESHIMA ,  Mehmet HUSNU ,  Jim STONE

    发明人： Dennis ESHIMA ,  Mehmet HUSNU ,  Jim STONE

    IPC分类号： G01T1/24 ,  A61B6/04 ,  A61N5/10 ,  G01T1/167

    CPC分类号： A61B6/037 ,  A61B6/12 ,  A61B6/4241 ,  A61N5/1049 ,  A61N2005/1052 ,  G01T1/1614

    摘要： A tumor treatment apparatus may include an array of collimated CZT detectors configured to intersect a known coordinate and measure gamma radiation activity, for example at 511 keV. A radiation delivery system may be configured to direct radiation through the known coordinate on the basis of the gamma radiation activity. A translatable and rotatable table may be configured to support a tumor host, wherein the tumor is positionable relative to the known coordinate on the basis of the gamma radiation activity emitted by the tumor and measured by the array of collimated CZT detectors. Radiation from the radiation delivery system may be delivered to the tumor at the known coordinate, and may be delivered in an intra-operative surgical environment.

    摘要翻译： 肿瘤治疗装置可以包括被配置为与已知坐标相交并且测量γ辐射活动的准直CZT检测器阵列，例如在511keV。 辐射递送系统可以被配置为基于伽马辐射活动来引导辐射通过已知坐标。 可翻译和可旋转的桌子可以被配置为支撑肿瘤宿主，其中根据由肿瘤发射的伽马辐射活动并通过准直的CZT检测器阵列测量的肿瘤可相对于已知坐标定位。 来自辐射递送系统的辐射可以以已知的坐标递送到肿瘤，并且可以在手术中的手术环境中递送。

    METHOD AND SYSTEM FOR AUTOMATED QUALITY CONTROL PLATFORM
    7.
    发明申请
    METHOD AND SYSTEM FOR AUTOMATED QUALITY CONTROL PLATFORM 审中-公开
    自动质量控制平台的方法与系统

    公开(公告)号：US20130018618A1

    公开(公告)日：2013-01-17

    申请号：US13550030

    申请日：2012-07-16

    申请人： Dennis Eshima ,  Mehmet Husnu ,  Jim Stone

    发明人： Dennis Eshima ,  Mehmet Husnu ,  Jim Stone

    IPC分类号： G06F19/00

    CPC分类号： G06Q10/06395 ,  G06Q10/20 ,  G21G1/0005

    摘要： A method and system for performing automated quality control analysis of a plurality of radiopharmaceuticals are provided. The method includes uniquely identifying each of the plurality of radiopharmaceuticals, and identifying and implementing a tailored quality control program for each of the radiopharmaceuticals. The method further includes automatically performing a plurality of selected quality control tests for each of the radiopharmaceuticals based on the tailored quality control program, and collecting information produced by the plurality of selected quality control tests.

    摘要翻译： 提供了一种用于执行多种放射性药物的自动化质量控制分析的方法和系统。 该方法包括唯一地识别多个放射性药物中的每一个，以及为每个放射性药物识别和实施定制的质量控制程序。 该方法还包括基于定制的质量控制程序自动执行针对每个放射性药物的多个选择的质量控制测试，以及收集由多个选择的质量控制测试产生的信息。

    PHARMACEUTICAL PRODUCTION MANAGEMENT SYSTEM
    10.
    发明申请
    PHARMACEUTICAL PRODUCTION MANAGEMENT SYSTEM 审中-公开
    医药生产管理系统

    公开(公告)号：US20110029445A1

    公开(公告)日：2011-02-03

    申请号：US12848031

    申请日：2010-07-30

    申请人： Bretten Whittacre ,  Dennis Eshima ,  Arris Robinson ,  Troy Connelly

    发明人： Bretten Whittacre ,  Dennis Eshima ,  Arris Robinson ,  Troy Connelly

    IPC分类号： G06Q50/00

    CPC分类号： G06Q10/06 ,  G06Q30/018 ,  G09B5/00 ,  G09B7/00 ,  G09B19/003

    摘要： A computer includes a memory and a processor, the memory having instrul. A computer-implemented method, a computer comprising a storage device, a memory and a processor, the storage device having instructions stored therein. The instructions, which when executed by the processor, causes the computer to (1) receive, at the production module, a request for production of a radioactive pharmaceutical; (2) verify, utilizing a training module on the computer, completion by the user of at least a training program corresponding to production of the radioactive pharmaceutical; (3) verify completion by the user of equipment calibration requirements and equipment qualification requirements for the equipment that is used in the production of the radioactive pharmaceutical; and (4) prevent access to further operations of the production module if the training program has not been completed, the equipment calibration requirements have not been completed or the equipment qualification requirements have not been completed.

    摘要翻译： 计算机包括存储器和处理器，存储器具有通用性。 计算机实现的方法，包括存储装置，存储器和处理器的计算机，所述存储装置具有存储在其中的指令。 指令在处理器执行时使计算机（1）在生产模块处接收放射性药物生产请求; （2）验证使用计算机上的培训模块，用户至少完成与放射性药物生产相对应的培训计划; （3）验证用户对放射性药物生产所用设备的设备校准要求和设备资质要求; （4）如果培训计划尚未完成，设备校准要求尚未完成或设备资质要求尚未完成，则不得进一步开展生产模块的操作。