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1.发明授权Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy 失效混合复合物作为移动和对比试剂在NMR成像和光谱学
公开(公告)号：US4915933A
公开(公告)日：1990-04-10
申请号：US878651
申请日：1986-06-26
Applicant: Nicholas A. Matwiyoff
Inventor： Nicholas A. Matwiyoff
CPC classification number: A61K49/06 , Y10S436/806 , Y10T436/24
Abstract: Mixed anionic complexes of the type (MW.sub.m Y.sub.n Z.sub.p).sup.r- wherein M is a paramagnetic ion; W, Y, and Z are each different ligands which chelate M; and m+n+p.gtoreq.2 but preferably less than 5, with the proviso that at least two different ligands W, Y, Z are present in the complex; are provided as versatile NMR contrast and shift reagents, especially for clinical diagnostic imaging and spectroscopic procedures. In an exemplary embodiment, at least one of the ligands W, Y, Z is metabolizable by the target tissue, and at least one of the ligands W, Y, Z is substantially inert; the complex is thus tailorable to improve both physiological tolerance and tissue specificity of NMR contrast and shift reagents, while maintaining excellent contrast and shift effects for reliable and accurate results.
Abstract translation: 类型（MWmYnZp）r-的混合阴离子络合物，其中M是顺磁离子; W，Y和Z各自是螯合M的不同配体; 并且m + n + p> / = 2，但优选小于5，条件是在络合物中存在至少两种不同的配体W，Y，Z; 被提供作为通用的NMR对比和转移试剂，特别是临床诊断成像和光谱程序。 在一个示例性实施方案中，配体W，Y，Z中的至少一个可被靶组织代谢，并且配体W，Y，Z中的至少一个基本上是惰性的; 因此，该复合物可以改进，以改善NMR对比度和转移试剂的生理学耐受性和组织特异性，同时保持优异的对比度和偏移效果以获得可靠和准确的结果。
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Patent Agency Ranking
公开(公告)号：US5906807A
公开(公告)日：1999-05-25
申请号：US405017
申请日：1995-03-16
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
CPC classification number: A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
Abstract translation: 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂还可以调节组织以增强非特异性成像剂的吸收。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。
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公开(公告)号：US06375927B1
公开(公告)日：2002-04-23
申请号：US09506086
申请日：2000-02-17
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
IPC: A61K5100
CPC classification number: A61K51/081 , A61K47/6415 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance up-take of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
Abstract translation: 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂也可以调理组织以增强非特异性成像剂的摄取。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。
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公开(公告)号：US6033644A
公开(公告)日：2000-03-07
申请号：US186096
申请日：1998-11-05
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
CPC classification number: A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
Abstract translation: 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂还可以调节组织以增强非特异性成像剂的吸收。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。
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5.发明授权Enhancement of abnormal tissue uptake of antibodies, tumor-specific agents or conjugates thereof for diagnostic imaging or therapy 失效增强抗体，肿瘤特异性试剂或其缀合物的异常组织摄取用于诊断成像或治疗
公开(公告)号：US5399338A
公开(公告)日：1995-03-21
申请号：US694151
申请日：1991-05-01
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff , Buck A. Rhodes
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff , Buck A. Rhodes
CPC classification number: A61K49/16 , A61K47/48261 , A61K49/085 , A61K49/14 , A61K51/08 , A61K51/081 , A61K51/1033 , A61K51/1045 , A61K51/1087 , A61K2123/00
Abstract: Biomodulators, in conjunction with antibodies, tumor-specific agents or conjugates thereof, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity.
Abstract translation: 结合抗体的生物调节剂，任选与成像活性部分连接的肿瘤特异性试剂或其缀合物可以施用于宿主以增强其图像，例如NMR-，X射线或放射线图像，优选地通过增加异常 组织信号强度。
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公开(公告)号：US5401489A
公开(公告)日：1995-03-28
申请号：US694325
申请日：1991-05-01
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
CPC classification number: A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
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