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公开(公告)号：US5914096A
公开(公告)日：1999-06-22
申请号：US74377
申请日：1998-05-08
Applicant: Robert B. Palmer , Jerry L. Born
Inventor： Robert B. Palmer , Jerry L. Born
CPC classification number: C07B59/004 , A61K51/0497 , A61K51/088 , C07F9/68
Abstract: Radioactive arsenic (.sup.72 As) labelled tissue specific ligands are prepared and used in the medical imaging of malignant breast or prostate tumors.
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公开(公告)号：US5906807A
公开(公告)日：1999-05-25
申请号：US405017
申请日：1995-03-16
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
CPC classification number: A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
Abstract translation: 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂还可以调节组织以增强非特异性成像剂的吸收。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。
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公开(公告)号：US5401489A
公开(公告)日：1995-03-28
申请号：US694325
申请日：1991-05-01
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
CPC classification number: A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
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Patent Agency Ranking
公开(公告)号：US06375927B1
公开(公告)日：2002-04-23
申请号：US09506086
申请日：2000-02-17
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
IPC: A61K5100
CPC classification number: A61K51/081 , A61K47/6415 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance up-take of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
Abstract translation: 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂也可以调理组织以增强非特异性成像剂的摄取。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。
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5.发明授权Image enhancement by coadministration of biomodulators and structurally modified imaging agents 失效通过共同给予生物调节剂和结构修饰的成像剂的图像增强
公开(公告)号：US5240693A
公开(公告)日：1993-08-31
申请号：US694157
申请日：1991-05-01
Applicant: Jerry L. Born , Dennis Eshima , Frank O. Kroh , Paul L. Mann
Inventor： Jerry L. Born , Dennis Eshima , Frank O. Kroh , Paul L. Mann
CPC classification number: A61K49/085 , A61K49/10 , A61K49/105 , A61K51/0491 , A61K51/0497 , A61K51/081 , A61B6/037 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators can be administered together with an agent such as a drug or an imaging agent (specific or non-specific) structurally modified to take advantage of perturbations of cell oligosaccharide displays caused by biomodulators, to enhance images of a host, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity. Biomodulators condition tissue to enhance or otherwise modify up-take of the drug or structurally modified imaging agent.
Abstract translation: 生物调节剂可与诸如药物或成像剂（特异性或非特异性）的药剂一起施用，其结构修饰以利用由生物调节剂引起的细胞寡糖显示剂的扰动，以增强宿主的图像，例如NMR-， 优选通过增加异常组织信号强度的X射线或放射线图像。 生物调节剂调节组织以增强或以其它方式改变药物或结构改性成像剂的摄取。
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公开(公告)号：US6106804A
公开(公告)日：2000-08-22
申请号：US874946
申请日：1997-06-13
Applicant: Robert B. Palmer , Jerry L. Born
Inventor： Robert B. Palmer , Jerry L. Born
CPC classification number: C07B59/004 , A61K51/0497 , A61K51/088 , C07F9/68
Abstract: Radioactive arsenic (.sup.72 As) labelled tissue specific ligands are prepared and used in the medical imaging of malignant breast or prostate tumors.
Abstract translation: 放射性砷（72As）标记的组织特异性配体被制备并用于恶性乳腺或前列腺肿瘤的医学成像。
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公开(公告)号：US6033644A
公开(公告)日：2000-03-07
申请号：US186096
申请日：1998-11-05
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
CPC classification number: A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
Abstract translation: 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂还可以调节组织以增强非特异性成像剂的吸收。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。
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8.发明授权Enhancement of abnormal tissue uptake of antibodies, tumor-specific agents or conjugates thereof for diagnostic imaging or therapy 失效增强抗体，肿瘤特异性试剂或其缀合物的异常组织摄取用于诊断成像或治疗
公开(公告)号：US5399338A
公开(公告)日：1995-03-21
申请号：US694151
申请日：1991-05-01
Applicant: Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff , Buck A. Rhodes
Inventor： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff , Buck A. Rhodes
CPC classification number: A61K49/16 , A61K47/48261 , A61K49/085 , A61K49/14 , A61K51/08 , A61K51/081 , A61K51/1033 , A61K51/1045 , A61K51/1087 , A61K2123/00
Abstract: Biomodulators, in conjunction with antibodies, tumor-specific agents or conjugates thereof, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity.
Abstract translation: 结合抗体的生物调节剂，任选与成像活性部分连接的肿瘤特异性试剂或其缀合物可以施用于宿主以增强其图像，例如NMR-，X射线或放射线图像，优选地通过增加异常 组织信号强度。
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