公开(公告)号：US11197982B2

公开(公告)日：2021-12-14

申请号：US16361630

申请日：2019-03-22

Applicant: David Sharpe Heister

Inventor： David Sharpe Heister

IPC: A61M25/10 ,  A61M25/00 ,  A61B17/00

Abstract: A balloon catheter is disclosed for endovascular procedures. In one embodiment, among others, the balloon catheter includes an elongated catheter body. At a distal end, the catheter body also includes an angled tip and a balloon adjacent to the angled tip. The balloon is inflatable to form an oblong shape.

公开(公告)号：US09575062B2

公开(公告)日：2017-02-21

申请号：US14302341

申请日：2014-06-11

Applicant: Anand Natrajan ,  David Sharpe ,  Qingping Jiang

Inventor： Anand Natrajan ,  David Sharpe ,  Qingping Jiang

IPC: G01N33/543 ,  C07D219/04 ,  C07D401/12 ,  C07D219/14

CPC classification number: G01N33/54393 ,  C07D219/04 ,  C07D219/14 ,  C07D401/12 ,  C09B15/00 ,  Y10T436/13

Abstract: Hydrophilic, chemiluminescent acridinium compounds containing zwitterions are disclosed. These acridinium compounds, when used as chemiluminescent labels in immunochemistry assays and the like, exhibit decreased non-specific binding to solid phases and provide increased assay sensitivity.

Abstract translation: 公开了含有两性离子的亲水的，化学发光的吖啶鎓化合物。 当这些吖啶鎓化合物在免疫化学测定等中用作化学发光标记时，表现出与固相的非特异性结合降低并提供增加的测定灵敏度。

公开(公告)号：US09487480B2

公开(公告)日：2016-11-08

申请号：US13699435

申请日：2011-05-18

Applicant: Anand Natrajan ,  David Sharpe ,  David Wen ,  Qingping Jiang

Inventor： Anand Natrajan ,  David Sharpe ,  David Wen ,  Qingping Jiang

IPC: C07C309/13 ,  C07D207/14 ,  C07D207/452 ,  A61K47/48 ,  C07C309/14 ,  C07D207/46 ,  C07D403/12 ,  C07D493/10 ,  C07D495/04 ,  C07F9/09

CPC classification number: C07D207/452 ,  A61K47/48061 ,  A61K47/48284 ,  A61K47/545 ,  A61K47/643 ,  C07C309/14 ,  C07D207/46 ,  C07D403/12 ,  C07D493/10 ,  C07D495/04 ,  C07F9/091 ,  C07K1/13 ,  C07K7/06 ,  C07K14/765 ,  C09B11/24 ,  G01N33/5306

Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.

Abstract translation: 用于改性疏水性分子以提高其溶解度和/或降低其非特异性结合的含两相元素的化合物。 含有两性离子的化合物可适用于可检测标记如生物素和荧光素的改性以改善其溶解度。 含有两性离子的化合物也可用于制备蛋白质，肽和其它大分子的缀合物或用于交联分子和/或大分子。

公开(公告)号：US09353056B2

公开(公告)日：2016-05-31

申请号：US13699435

申请日：2011-05-18

Applicant: Anand Natrajan ,  David Sharpe ,  David Wen ,  Qingping Jiang

Inventor： Anand Natrajan ,  David Sharpe ,  David Wen ,  Qingping Jiang

IPC: C07C309/13 ,  C07D207/14 ,  C07D207/452 ,  A61K47/48 ,  C07C309/14 ,  C07D207/46 ,  C07D403/12 ,  C07D493/10 ,  C07D495/04 ,  C07F9/09

Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.

公开(公告)号：US07648596B2

公开(公告)日：2010-01-19

申请号：US11653387

申请日：2007-01-16

Applicant: David Sharpe ,  Firooz Rasouli ,  John F. Cunningham

Inventor： David Sharpe ,  Firooz Rasouli ,  John F. Cunningham

IPC: B22F1/00

CPC classification number: B22F3/18 ,  B21B3/00 ,  B21B9/00 ,  B21B27/06 ,  B21B27/106 ,  B21B39/006 ,  B21B39/08 ,  B21B45/004 ,  B21B2045/006 ,  B22F2003/1053 ,  B22F2003/248 ,  B22F2998/10 ,  B22F2999/00 ,  C21D1/42 ,  C21D7/13 ,  Y02P10/253 ,  B22F3/105 ,  B22F3/16 ,  B22F3/24 ,  B22F3/14 ,  B22F2201/10

Abstract: An apparatus for rolling of a powder metallurgical metallic workpiece is provided having a feeding device, a first induction heating apparatus in operable communication with a first RF generator and at least a first hot rolling mill. A process control device monitors at least one parameter of the first RF generator and outputs a signal. A method for continuous rolling of a metallic workpiece is also provided using the apparatus for rolling. The process control device signal can be used to monitor metallurgical properties of the workpiece and provide in-line evaluation of the workpiece.

Abstract translation: 提供了一种用于轧制粉末冶金金属工件的装置，其具有进给装置，与第一RF发生器和至少第一热轧机可操作地连通的第一感应加热装置。 过程控制设备监视第一RF发生器的至少一个参数并输出信号。 也可以使用轧制装置来提供金属制工件的连续轧制方法。 过程控制装置信号可用于监测工件的冶金性能，并提供对工件的在线评估。

公开(公告)号：US20090318627A1

公开(公告)日：2009-12-24

申请号：US12278621

申请日：2007-02-06

Applicant: Anand Natrajan ,  David Sharpe ,  Jim Costello ,  Qingping Jiang

Inventor： Anand Natrajan ,  David Sharpe ,  Jim Costello ,  Qingping Jiang

IPC: C08G63/91 ,  C07D219/00 ,  C07J43/00 ,  C07K2/00 ,  C07H21/00

CPC classification number: C07D219/04

Abstract: Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium-functionalized solid-phase supports comprise a solid phase support linked to a chemiluminescent substituted acridinium compound through a linker group covalently attached to the nitrogen atom of the acridinium nucleus and the solid phase support as exemplified in FIG. 1.

Abstract translation: 公开了吖啶鎓官能化固相载体和制备吖啶酮官能化固相载体的方法。 吖啶酮官能化的固相载体包括通过共价连接到吖啶核的氮原子的连接基团和固相载体连接到化学发光的取代的吖啶鎓化合物的固相载体，如图1所示。 1。

公开(公告)号：US07319041B2

公开(公告)日：2008-01-15

申请号：US10260504

申请日：2002-09-27

Applicant: Anand Natrajan ,  Todd Sells ,  Hartmut Schroeder ,  Guohan Yang ,  David Sharpe ,  Qingping Jiang ,  Hana Lukinsky ,  Say-Jong Law

Inventor： Anand Natrajan ,  Todd Sells ,  Hartmut Schroeder ,  Guohan Yang ,  David Sharpe ,  Qingping Jiang ,  Hana Lukinsky ,  Say-Jong Law

IPC: G01N33/533 ,  G01N33/536 ,  G01N33/53 ,  C07D219/00

CPC classification number: C07D219/04 ,  B82Y15/00 ,  G01N33/533 ,  G01N33/542 ,  G01N33/588 ,  Y10S435/968 ,  Y10S436/80

Abstract: Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base formation, or acridinium sulfonamides with or without electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus.

Abstract translation: 化学发光吖啶鎓化合物用于均相测定以确定样品中分析物的浓度，而不需要强酸或强碱处理。 化学发光的吖啶鎓化合物包括在吖啶鎓核上的C2和/或C7位上具有给电子官能团的吖啶酯以抑制假碱形成，或在C2和/或C7位置具有或不具有给电子官能团的吖啶鎓磺酰胺， ium核。

公开(公告)号：US20060101044A1

公开(公告)日：2006-05-11

申请号：US10982367

申请日：2004-11-05

Applicant: Linqi Liu ,  Robert Neugebauer ,  David Sharpe ,  Nattavut Sutyanyong ,  Calisto Zuzarte

Inventor： Linqi Liu ,  Robert Neugebauer ,  David Sharpe ,  Nattavut Sutyanyong ,  Calisto Zuzarte

IPC: G06F17/00 ,  G06F7/00

CPC classification number: G06F17/30418 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99942

Abstract: Disclosed is a data processing system, a data processing system implemented method and an article of manufacture for executing a query having a union all operator. The data processing system implemented method directs the data processing system to execute a query against a data object. The query has a union all operator and has a set of data modifying operators. The set of data modifying operators is associated with the union all operator. The union all operator references the data object. The data processing system implemented method includes preventing the union all operator from being applied to the data object, and applying the set of data modifying operators against the data object.

Abstract translation: 公开了一种数据处理系统，数据处理系统实现方法和用于执行具有联合全部操作者的查询的制品。 数据处理系统实现的方法指导数据处理系统对数据对象执行查询。 该查询具有一个union all运算符，并具有一组数据修改运算符。 数据修改运算符的集合与union all运算符相关联。 union all操作符引用数据对象。 数据处理系统实现的方法包括防止所有操作员的联合被应用于数据对象，并且对数据对象应用一组数据修改运算符。

公开(公告)号：US07007237B1

公开(公告)日：2006-02-28

申请号：US09563371

申请日：2000-05-03

Applicant: Timothy David Sharpe

Inventor： Timothy David Sharpe

IPC: G06F9/00

CPC classification number: A61F5/03

Abstract: A method and system that allows the user to fetch a subsequent web page while maintaining the current web page as the active web page. The next web page is fetched “in the background” and stored in cache memory without interrupting the user. Once the requested web page has been stored in cache, an indicator is added to the history list allowing the user access to the processed web page. In order to view the next web page, the user simply selects the appropriate icon on the user interface, such as the forward button which is akin to selecting the back or forward button to scroll through the history of web pages. Since the web page is in the cache, it is displayed relatively quickly and since the user selects when to display the page, there is no interruption.

Abstract translation: 一种方法和系统，其允许用户在将当前网页保持为活动网页的同时获取后续网页。 下一个网页在后台获取并存储在缓存中，而不会中断用户。 一旦所请求的网页已被存储在高速缓存中，则指示符被添加到历史列表中，允许用户访问处理的网页。 为了查看下一个网页，用户只需在用户界面上选择适当的图标，例如转发按钮，类似于选择后退或转发按钮来浏览网页的历史记录。 由于网页在缓存中，所以显示得相对较快，因为用户选择何时显示页面，所以不会有中断。

公开(公告)号：US20050004906A1

公开(公告)日：2005-01-06

申请号：US10910119

申请日：2004-08-03

Applicant: Paul Huffman ,  Kathy McKnight ,  David Sharpe ,  Daniel Zilio

Inventor： Paul Huffman ,  Kathy McKnight ,  David Sharpe ,  Daniel Zilio

IPC: G06F12/00 ,  G06F17/30

CPC classification number: G06F16/24554 ,  G06F16/24557 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99935 ,  Y10S707/99943 ,  Y10S707/99945

Abstract: A query processing system has a query processor and a data manager. The query processor calls the data manager to carry out data access for a query including a filtering operation. The data manager accesses the data in a set of data and before returning the data, initiates a callback to the query processor to determine if the located data meets the filtering criteria. Where the data does not satisfy the filtering criteria, the data manager seeks additional data in the set of data, without having to return the first located data to the query processor.

Abstract translation: 查询处理系统具有查询处理器和数据管理器。 查询处理器调用数据管理器对包括过滤操作的查询执行数据访问。 数据管理器访问一组数据中的数据，并在返回数据之前，向查询处理器发起回调，以确定所查找的数据是否满足过滤条件。 在数据不满足过滤标准的情况下，数据管理器在数据集中寻求附加数据，而不必将第一定位数据返回给查询处理器。