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公开(公告)号：US08685945B2
公开(公告)日：2014-04-01
申请号：US13302439
申请日：2011-11-22
IPC分类号： A61K31/70
CPC分类号： A61K47/26 , A61K9/0048 , A61K31/08 , A61K31/736 , A61K47/02 , A61K47/10 , A61K47/36
摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。
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公开(公告)号：US20100196415A1
公开(公告)日：2010-08-05
申请号：US12701339
申请日：2010-02-05
IPC分类号： A61K31/736 , C09F1/04 , A61P27/02
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。
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公开(公告)号：US07552648B2
公开(公告)日：2009-06-30
申请号：US11904705
申请日：2007-09-28
IPC分类号： G01N3/00
CPC分类号： G01N3/12 , G01N33/383 , G01N2203/0003 , G01N2203/0017 , G01N2203/0019 , G01N2203/0048 , G01N2203/0284 , G01N2203/0605
摘要： Methods of determining the mechanical properties of a sample include applying a first pressure condition to a first portion of the sample and applying a second pressure condition to the second portion of the sample, the second pressure condition being different than the first pressure condition.
摘要翻译： 确定样品的机械性能的方法包括将第一压力条件施加到样品的第一部分，并将第二压力条件施加到样品的第二部分，第二压力条件不同于第一压力条件。
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4.发明授权Use of bis-amines to enhance the antimicrobial activity of aqueous compositions 有权使用双胺来增强含水组合物的抗微生物活性公开(公告)号：US07445771B2
公开(公告)日：2008-11-04
申请号：US11008027
申请日：2004-12-09
IPC分类号： A61K31/74
CPC分类号： C07C215/14 , C07C215/18
摘要： The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
摘要翻译： 描述了使用双胺来增强药物组合物的抗微生物活性。 双胺特别可用于增强水性眼用组合物如人造眼泪或眼部润滑剂的抗微生物活性，以及消毒隐形眼镜的溶液。
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公开(公告)号：US06995123B2
公开(公告)日：2006-02-07
申请号：US10738202
申请日：2003-12-17
CPC分类号： C11D1/10 , C11D1/88 , C11D3/0078 , Y10S514/912
摘要： Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.
摘要翻译： 描述隐形眼镜的清洁组合物。 该组合物包含多功能阴离子表面活性剂，其包括至少两个亲水解离头基团。 所描述的多官能表面活性剂（例如LED 3A）具有表面活性和螯合性质，并且已被发现在去除隐形眼镜中的蛋白沉积物方面特别有效。
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公开(公告)号：US5518731A
公开(公告)日：1996-05-21
申请号：US260482
申请日：1994-06-14
申请人： David L. Meadows
发明人： David L. Meadows
IPC分类号： A61K9/00 , A61K9/10 , A61K9/16 , A61K31/02 , A61K31/025 , A61P27/02 , A61K9/14 , A61K47/06 , A61K47/32 , A61K47/34
CPC分类号： A61K9/0026 , A61K31/02 , A61K31/025 , A61K9/0048 , A61K9/10 , A61K9/1635 , Y10S514/912 , Y10S514/963
摘要： Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone liquid carriers. The suspended drug delivery vehicles may be water labile or water stable and incorporate therapeutic or diagnostic compounds which remain stable and pharmaceutically effective for extended periods. The pharmaceutical compositions have improved bioavailability, are capable of low dose volume delivery, and do not leach the incorporated therapeutic or diagnostic compounds into the liquid carriers making them well suited for multi-dose packaging and administration.
摘要翻译： 公开了用于水性生理系统的非水性药物组合物，其包含悬浮在非水性全氟化碳或氟化硅氧烷液体载体中的药物递送载体。 悬浮药物递送载体可以是水不稳定的或水稳定的，并且包含长时间保持稳定和药学有效的治疗或诊断化合物。 药物组合物具有改善的生物利用度，能够低剂量体积递送，并且不将所掺入的治疗或诊断化合物浸入液体载体中，使得它们非常适合于多剂量包装和给药。
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公开(公告)号：US5441732A
公开(公告)日：1995-08-15
申请号：US853135
申请日：1992-03-18
申请人： Anne L. Hoeg , David L. Meadows
发明人： Anne L. Hoeg , David L. Meadows
IPC分类号： A61K9/00 , A61K9/06 , A61K9/107 , A61K9/16 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/38 , A61K31/19 , A01N25/04 , A61K31/745
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/38 , A61K9/0019 , A61K9/06 , A61K9/1647 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915 , Y10S514/938 , Y10S514/942
摘要： Reversibly gelling aqueous and oil emulsions are disclosed which can be modified to incorporate oil soluble pharmaceutical compounds for delivery to physiological systems in a soluble form and which undergo significant changes in viscosity in response to substantially simultaneous changes in both temperature and pH. The compositions are formed of relatively low concentrations of a stable combination of at least one pH-sensitive reversibly gelling polymer, at least one temperature-sensitive reversibly gelling polymer and at least one organic oil. The compositions can be formulated to exhibit a sol-gel transition over a wide range of conditions and viscosities and may be modified to incorporate a pharmaceutical compound for utilization as droppable or injectable drug delivery systems which will gel following administration to a physiological system for the sustained delivery of such pharmaceutical compounds.
摘要翻译： 公开了可反射胶凝的水和油乳液，其可以被修饰以引入油溶性药物化合物，以便以可溶形式递送到生理系统，并且响应于温度和pH两者的基本上同时的变化而经历显着的粘度变化。 组合物由相对低浓度的至少一种pH敏感的可逆胶凝聚合物，至少一种温度敏感的可逆胶凝聚合物和至少一种有机油的稳定组合形成。 组合物可以配制成在宽范围的条件和粘度下显示出溶胶 - 凝胶转变，并且可以被修饰以引入药物化合物以用作可滴注或可注射的药物递送系统，其将在施用于生理系统之后凝胶用于持续的 这种药物化合物的递送。
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公开(公告)号：US5173298A
公开(公告)日：1992-12-22
申请号：US588697
申请日：1990-09-27
申请人： David L. Meadows
发明人： David L. Meadows
IPC分类号： A61K9/107 , A61K9/00 , A61K9/10 , A61K9/16 , A61K9/50 , A61K31/02 , A61K31/025 , A61K47/06 , A61K47/18 , A61K47/24
CPC分类号： A61K9/0026 , A61K31/02 , A61K31/025 , A61K9/0048 , A61K9/10 , A61K9/1635 , Y10S514/912 , Y10S514/963 , Y10S514/965
摘要： Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone liquid carriers. The suspended drug delivery vehicles may be water labile or water stable and incorporate therapeutic or diagnostic compounds which remain stable and pharmaceutically effective for extended periods. The pharmaceutical compositions possess extended shelf-lives and do not leach the incorporated therapeutic or diagnostic compounds into the liquid carriers making them well suited for multi-dose packaging and administration.
摘要翻译： 公开了用于水性生理系统的非水性药物组合物，其包含悬浮在非水性全氟化碳或氟化硅氧烷液体载体中的药物递送载体。 悬浮药物递送载体可以是水不稳定的或水稳定的，并且包含长时间保持稳定和药学有效的治疗或诊断化合物。 药物组合物具有延长的保质期，并且不将所掺入的治疗或诊断化合物浸入液体载体中，使得它们非常适合于多剂量包装和给药。
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公开(公告)号：US5018578A
公开(公告)日：1991-05-28
申请号：US563765
申请日：1990-08-06
申请人： Wadood El Rabaa , R. Clay Cole , David L. Meadows
发明人： Wadood El Rabaa , R. Clay Cole , David L. Meadows
IPC分类号： E21B33/138 , E21B43/16 , E21B43/26
CPC分类号： E21B43/162 , E21B33/138 , E21B43/26 , E21B43/261
摘要： The present invention relates to a method of hydraulically fracturing a first zone with a first fluid and an adjacent second zone with a second fluid which preferably is chemically reactive with the first fluid to produce a precipitate or gel upon contact therewith. Preferably the fluids are separated from one another in the wellbore and are pumped into their respective zones at approximately the same rate so that they spread radially outward from the wellbore into the formation. Upon contact, the two fluids react with one another to form a precipitate or gel at the interface between the two zones thereby arresting further fracture propagation between the zones.
摘要翻译： 本发明涉及一种用第一流体和相邻的第二区域水力压裂第一区域的方法，其中第二流体优选与第一流体发生化学反应，以在与第一流体接触时产生沉淀物或凝胶。 优选地，流体在井筒中彼此分离，并以大致相同的速率被泵送到它们各自的区域中，使得它们从井眼径向向外扩展到地层中。 接触后，两种流体彼此反应，以在两个区域之间的界面处形成沉淀物或凝胶，从而阻止区域之间进一步的裂缝传播。
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公开(公告)号：US09175249B2
公开(公告)日：2015-11-03
申请号：US12831890
申请日：2010-07-07
IPC分类号： A61K31/765 , C11D3/48 , A61K9/00 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/00 , C11D3/22
CPC分类号： C11D3/48 , A61K9/0048 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/008 , C11D3/222 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.
摘要翻译： 本发明涉及包含环氧乙烷环氧丁烷和半乳甘露聚糖如瓜尔胶的组合物。 组合物特别适用于眼科应用，如隐形眼镜消毒和再湿润。 还考虑了使用本发明的组合物治疗干眼症的方法。
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