公开(公告)号：US20070249615A1

公开(公告)日：2007-10-25

申请号：US11737966

申请日：2007-04-20

Applicant: Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

Inventor： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

IPC: A61K31/498 ,  C07D487/02

CPC classification number: C07D471/04

Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

Abstract translation: 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R 2，R 6A，R 6B， >和R＆gt; 8如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。

公开(公告)号：US20240374697A1

公开(公告)日：2024-11-14

申请号：US18534557

申请日：2023-12-08

Applicant: Dong SHEN ,  David BROWN ,  RNAimmune, Inc.

Inventor： Dong SHEN ,  David BROWN

IPC: A61K39/00 ,  A61K9/51 ,  A61K45/06 ,  A61P37/04 ,  C07K14/47 ,  C12P19/34

Abstract: Compositions and methods are provided for potent mRNA vaccines for treatment of cancer with mutations in ras gene family multiplexed with TP53. The compositions include a pharmaceutical composition containing mRNA molecules encoding multiple peptides of a group of somatic mutations together with a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, and subcutaneous injection.

公开(公告)号：US10857315B2

公开(公告)日：2020-12-08

申请号：US15119128

申请日：2015-02-20

Applicant: David Brown

Inventor： David Brown

IPC: A61M15/00 ,  A61M11/02 ,  B05B11/06

Abstract: To disperse inhaling powders, a powder is positioned in a passage of a device for dispersing powders, wherein the passage has one or more exits, one or more inlets and one or more obstructions to block the movement or to contain the powder within the device before use. A breaching pressure differential between the one or more exits and the one or more inlets of the passage is applied to breach the one or more obstructions, which fully or partially aerosolizes the powder, thus releasing a fully or partially aerosolized powder from the device.

公开(公告)号：US10797215B2

公开(公告)日：2020-10-06

申请号：US15254918

申请日：2016-09-01

Applicant: Boris Russ ,  David Brown ,  Jared Lynch ,  Tristan Day ,  Nelson E. Coates ,  Ayaskanta Sahu ,  Jason D. Forster ,  Jeffrey Snyder ,  Jeffrey J. Urban ,  Rachel A. Segalman

Inventor： Boris Russ ,  David Brown ,  Jared Lynch ,  Tristan Day ,  Nelson E. Coates ,  Ayaskanta Sahu ,  Jason D. Forster ,  Jeffrey Snyder ,  Jeffrey J. Urban ,  Rachel A. Segalman

IPC: H01L35/26 ,  H01L35/16 ,  H01L35/34

Abstract: This disclosure provides systems, methods, and apparatus related to graded thermoelectric materials. In one aspect, a method includes providing a plurality of nanostructures. The plurality of nanostructures comprise a thermoelectric material, with nanostructures of the plurality of nanostructures having first ligands disposed on surfaces of the nanostructures. The plurality of nanostructures is deposited on a substrate to form a layer. The layer is contacted with a solution containing second ligands. A ligand exchange process occurs where some of the first ligands disposed on the plurality of nanostructures are replaced with the second ligands. A first region of the layer is removed from contact with the solution so that the ligand exchange process does not occur in the first region of the layer, with the ligand exchange process occurring in the layer in contact with the solution. The layer is then removed from contact with the solution.

公开(公告)号：US20170069815A1

公开(公告)日：2017-03-09

申请号：US15254918

申请日：2016-09-01

Applicant: Boris Russ ,  David Brown ,  Jared Lynch ,  Tristan Day ,  Nelson E. Coates ,  Ayaskanta Sahu ,  Jason D. Forster ,  Jeffrey Snyder ,  Jeffrey J. Urban ,  Rachel A. Segalman

Inventor： Boris Russ ,  David Brown ,  Jared Lynch ,  Tristan Day ,  Nelson E. Coates ,  Ayaskanta Sahu ,  Jason D. Forster ,  Jeffrey Snyder ,  Jeffrey J. Urban ,  Rachel A. Segalman

IPC: H01L35/26 ,  H01L35/34 ,  H01L35/16

CPC classification number: H01L35/26 ,  H01L35/16 ,  H01L35/34

Abstract: This disclosure provides systems, methods, and apparatus related to graded thermoelectric materials. In one aspect, a method includes providing a plurality of nanostructures. The plurality of nanostructures comprise a thermoelectric material, with nanostructures of the plurality of nanostructures having first ligands disposed on surfaces of the nanostructures. The plurality of nanostructures is deposited on a substrate to form a layer. The layer is contacted with a solution containing second ligands. A ligand exchange process occurs where some of the first ligands disposed on the plurality of nanostructures are replaced with the second ligands. A first region of the layer is removed from contact with the solution so that the ligand exchange process does not occur in the first region of the layer, with the ligand exchange process occurring in the layer in contact with the solution. The layer is then removed from contact with the solution.

Abstract translation: 本公开提供了与分级热电材料相关的系统，方法和装置。 一方面，一种方法包括提供多个纳米结构。 多个纳米结构包括热电材料，多个纳米结构的纳米结构具有设置在纳米结构表面上的第一配体。 多个纳米结构沉积在基底上以形成层。 该层与含有第二配体的溶液接触。 发生配体交换过程，其中设置在多个纳米结构上的一些第一配体被第二配体取代。 去除该层的第一区域与溶液接触，使得配体交换过程不会发生在层的第一区域中，配体交换过程发生在与溶液接触的层中。 然后将该层与溶液接触除去。

公开(公告)号：US09492541B2

公开(公告)日：2016-11-15

申请号：US10939351

申请日：2004-09-14

Applicant: Viswanathan Srinivasan ,  Ralph Brown ,  David Brown ,  Juan Carlos Menendez ,  Venkatesh Balasubramanian ,  Somphet Peter Suphasawud

Inventor： Viswanathan Srinivasan ,  Ralph Brown ,  David Brown ,  Juan Carlos Menendez ,  Venkatesh Balasubramanian ,  Somphet Peter Suphasawud

IPC: A61K9/20 ,  A61K31/137 ,  A61K45/06 ,  A61K9/24 ,  A61K31/485

CPC classification number: A61K45/06 ,  A61K9/209 ,  A61K31/137 ,  A61K31/485 ,  A61K2300/00

Abstract: A pharmaceutical dosage form which comprises phenylepherine or a pharmaceutically acceptable salt thereof and a second drug. The dosage form provides a plasma concentration within the therapeutic range of the second drug over a period which is coextensive with at least about 70% of the period over which the dosage form provides a plasma concentration within the therapeutic range of phenylepherine. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

公开(公告)号：US09410310B1

公开(公告)日：2016-08-09

申请号：US14474838

申请日：2014-09-02

Applicant: Gene Eckert ,  Stephen Derby ,  David Brown

Inventor： Gene Eckert ,  Stephen Derby ,  David Brown

IPC: A47K1/05 ,  E03C1/32 ,  E03C1/18

CPC classification number: E03C1/324 ,  A47K1/05

Abstract: The sink system (10) includes a sink support frame (12) for supporting a sink (24). A vertical adjustment mechanism (30) secured between the sink support frame (12) and a rear wall (32) permits selective vertical movement of the sink support frame (12). A horizontal adjustment mechanism (40) secured between the sink support frame (12) and the sink (24) permits selective horizontal movement of the sink (24) away from and toward the rear wall (32). Flexible cold and hot water delivery lines (44, 46) and a flexible drain pipe (54) are secured between the rear wall (32) and a bottom surface of the sink. Vertical and horizontal movement of the sink (24) greatly facilitates use of the sink (24) by elderly and disabled persons using a wheelchair (56) and/or a walker. A two-sink cabinet embodiment (130) is also disclosed.

Abstract translation: 水槽系统（10）包括用于支撑水槽（24）的水槽支撑框架（12）。 固定在水槽支撑框架（12）和后壁（32）之间的垂直调节机构（30）允许水槽支撑框架（12）的选择性垂直运动。 固定在水槽支撑框架（12）和水槽（24）之间的水平调节机构（40）允许水槽（24）远离和朝向后壁（32）的选择性的水平移动。 灵活的冷热水输送管线（44,46）和柔性排水管（54）固定在后壁（32）和水槽底面之间。 水槽（24）的垂直和水平运动大大方便了使用轮椅（56）和/或步行器的老年人和残疾人使用水槽（24）。 还公开了一种双槽柜实施例（130）。

公开(公告)号：US09334081B2

公开(公告)日：2016-05-10

申请号：US13773740

申请日：2013-02-22

Applicant: Stephen Derby ,  Gene Eckert ,  David Brown ,  John McFadden

Inventor： Stephen Derby ,  Gene Eckert ,  David Brown ,  John McFadden

IPC: B65D5/72 ,  B65D25/00 ,  B65D5/20

CPC classification number: B65D5/72 ,  B65B5/105 ,  B65B43/54 ,  B65D5/2052 ,  B65D25/005

Abstract: The folding side-wall container (10, 62, 66) provides for efficient loading and unloading of the containers appropriate for retail re-supply of goods (52, 64, 90). Use of the containers as a distribution container (62) and a wholesale goods container (66) within an automated system (60) for automated transfer by a robotic picker (68) of goods (64) from the wholesale container (66) to the distribution container (62) minimizes labor costs in distribution of the goods (64). The container (10) includes a folding wall (22) that is releasably secured in a closed position by a top lid (34) having an engagement lip (42) that secures a top edge (46) of the folding side or front wall (22). Opening the top lid (34) and then folding down the front wall (22) permits efficient loading and unloading of the container (10).

Abstract translation: 折叠侧壁容器（10,62,66）提供适于货物再供应的容器（52,64,90）的有效装载和卸载。 使用容器作为自动化系统（60）内的分配容器（62）和批发货物容器（66），用于由货物（64）从批发容器（66）到机器人选择器（68）的自动转移 分销集装箱（62）最大限度地减少了货物分配中的劳动力成本（64）。 容器（10）包括折叠壁（22），其通过具有固定折叠侧或前壁的顶部边缘（46）的接合唇缘（42）的顶盖（34）可释放地固定在关闭位置 22）。 打开顶盖（34）然后向下折叠前壁（22）允许容器（10）的有效装载和卸载。

公开(公告)号：US09259591B2

公开(公告)日：2016-02-16

申请号：US12343386

申请日：2008-12-23

Applicant: David Brown ,  Christopher Genau ,  Kent W. Leyde ,  Shan Gaw ,  Jeffrey Stewart

Inventor： David Brown ,  Christopher Genau ,  Kent W. Leyde ,  Shan Gaw ,  Jeffrey Stewart

IPC: A61N1/378 ,  A61N1/375 ,  A61N1/372

CPC classification number: A61N1/3787 ,  A61N1/37223 ,  A61N1/375 ,  A61N1/3758

Abstract: An implantable medical device having a concave ceramic housing component; a concave metal housing component attached to the ceramic housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Another aspect of the invention provides an implantable medical device having a ceramic housing component; a metal housing component; a circumferential sealing member attached to a periphery of the ceramic housing component and to a periphery of the metal housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Still another aspect of the invention provides an implantable medical device with a first metal housing component; a second metal housing component, the second metal housing component forming an opening; a ceramic housing component disposed in the opening, the first metal housing component, the second metal housing component and the ceramic housing component cooperating to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure.

Abstract translation: 一种具有凹形陶瓷壳体部件的可植入医疗装置; 连接到陶瓷壳体部件的凹入金属壳体部件以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。 本发明的另一方面提供一种具有陶瓷壳体部件的可植入医疗装置; 金属外壳部件; 周向密封构件，其附接到陶瓷壳体部件的周边和金属壳体部件的周边，以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。 本发明的另一方面提供一种具有第一金属壳体部件的可植入医疗装置; 第二金属壳体部件，所述第二金属壳体部件形成开口; 设置在所述开口中的陶瓷壳体部件，所述第一金属壳体部件，所述第二金属壳体部件和所述陶瓷壳体部件协作以形成气密密封的壳体; 以及设置在所述外壳内的电子跨壳体磁通部件。

公开(公告)号：US09137429B2

公开(公告)日：2015-09-15

申请号：US13814766

申请日：2011-08-03

Applicant: Richard Topliss ,  Andrew Benjamin David Brown

Inventor： Richard Topliss ,  Andrew Benjamin David Brown

IPC: H04N5/225 ,  G02B27/64 ,  G03B5/00 ,  H04N1/00 ,  H04N5/232

CPC classification number: H04N5/2251 ,  G02B27/646 ,  G03B5/00 ,  G03B2205/0023 ,  G03B2205/0076 ,  H04N1/00307 ,  H04N5/2257 ,  H04N5/23287

Abstract: In a camera apparatus, two SMA actuator subsystems each comprise two SMA wires connected between a camera unit and a support structure, hooked over a pivot element defining pivot axes that lie in a common plane along the optical axis. Differential contraction of the SMA wires drives rotation. The SMA actuator subsystems are opposed, but the SMA wires of each subsystem are fixed respectively to the camera unit and the support structure, reducing the height. A non-conductive substrate supporting conductive tracks electrically connected to the SMA actuator system is configured as a flexure arrangement between the camera unit and the support structure. The flexure arrangement is connected to the camera unit at a position in the common plane reducing lateral resistance to tilt. Use of an intermediate connector element allows the circuit board to be arranged in front of the intermediate connector inside the height of the lens system.

Abstract translation: 在相机装置中，两个SMA致动器子系统各自包括连接在相机单元和支撑结构之间的两条SMA线，钩在枢轴元件上，该枢轴元件限定位于沿着光轴的公共平面中的枢转轴线。 SMA线的差动收缩驱动旋转。 SMA执行器子系统相对，但每个子系统的SMA线分别固定在摄像机单元和支撑结构上，降低了高度。 电连接到SMA致动器系统的支撑导电轨道的非导电衬底被配置为相机单元和支撑结构之间的挠曲布置。 弯曲布置在公共平面中的位置处连接到相机单元，减小横向阻力以倾斜。 使用中间连接器元件允许电路板布置在透镜系统的高度内的中间连接器的前面。