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公开(公告)号：US20120190105A1
公开(公告)日：2012-07-26
申请号：US13374899
申请日：2012-01-23
Applicant: John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong
Inventor： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong
CPC classification number: C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , G01N15/1459 , G01N2015/149
Abstract: A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.
Abstract translation: 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的相应微流体通道连接的通道。 柔性垫片可以防止泄漏，并允许流体通过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜，以允许空气逸出，并由皮下注射针插入液体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。
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公开(公告)号：US08993311B2
公开(公告)日：2015-03-31
申请号：US13506892
申请日：2012-05-23
Applicant: John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
Inventor： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
CPC classification number: C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
Abstract: A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
Abstract translation: 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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公开(公告)号：US08871500B2
公开(公告)日：2014-10-28
申请号：US13374898
申请日：2012-01-23
Applicant: John S. Foster , Daryl W. Grummitt , John C. Harley , Jaquelin K. Spong , Kimberly L. Turner
Inventor： John S. Foster , Daryl W. Grummitt , John C. Harley , Jaquelin K. Spong , Kimberly L. Turner
CPC classification number: G01N33/5005 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0633 , C12M47/04
Abstract: A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
Abstract translation: 描述了基于MEMS的系统和方法，用于将目标颗粒与流体流的其余部分分离。 该系统利用形成在基板上的独特的微加工可移动结构，其以旋转方式围绕一个或多个固定点移动，所述固定点都位于运动轴的一侧。 可移动结构由独立的力产生装置致动，该装置与其基板上形成的可移动结构完全分开。 这允许可移动结构完全浸没在样品流体中。
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4.发明申请公开(公告)号：US20220260480A1
公开(公告)日：2022-08-18
申请号：US17716007
申请日：2022-04-08
Applicant: John S. Foster , Mark A. Naivar , Kevin E. Shields , Daryl W. Grummitt , Timothy J. Wilt , Yareeve Zemel , Lily Li
Inventor： John S. Foster , Mark A. Naivar , Kevin E. Shields , Daryl W. Grummitt , Timothy J. Wilt , Yareeve Zemel , Lily Li
Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.
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Patent Agency Ranking
公开(公告)号：US08822207B2
公开(公告)日：2014-09-02
申请号：US13374899
申请日：2012-01-23
Applicant: John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong
Inventor： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong
CPC classification number: C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , G01N15/1459 , G01N2015/149
Abstract: A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.
Abstract translation: 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的相应微流体通道连接的通道。 柔性垫片可以防止泄漏，并允许流体通过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜，以允许空气逸出，并由皮下注射针插入液体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。
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公开(公告)号：US20120190104A1
公开(公告)日：2012-07-26
申请号：US13374898
申请日：2012-01-23
Applicant: John S. Foster , Daryl W. Grummitt , John C. Harley , Jaquelin K. Spong , Kimberly L. Turner
Inventor： John S. Foster , Daryl W. Grummitt , John C. Harley , Jaquelin K. Spong , Kimberly L. Turner
CPC classification number: G01N33/5005 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0633 , C12M47/04
Abstract: A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
Abstract translation: 描述了基于MEMS的系统和方法，用于将目标颗粒与流体流的其余部分分离。 该系统利用形成在基板上的独特的微加工可移动结构，其以旋转方式围绕一个或多个固定点移动，所述固定点都位于运动轴的一侧。 可移动结构由独立的力产生装置致动，该装置与其基板上形成的可移动结构完全分开。 这允许可移动结构完全浸没在样品流体中。
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公开(公告)号：US09194786B2
公开(公告)日：2015-11-24
申请号：US13507830
申请日：2012-08-01
Applicant: John S. Foster , Daryl W. Grummitt
Inventor： John S. Foster , Daryl W. Grummitt
CPC classification number: G01N15/1463 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0454 , B07C5/3425 , G01N15/1404 , G01N15/1425 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/1413 , G01N2015/149
Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.
Abstract translation: 一种使用粒子操纵级和多个激光询问区的基于MEMS的粒子操纵系统。 激光询问区域可用于评估粒子操纵阶段的有效性或准确性。 在一个示例性实施例中，颗粒操纵阶段是微制造的翼片式流体阀，其从流体流中的非目标颗粒排序目标颗粒。 激光询问阶段在翼片式分选阀的输入和输出处设置在微细加工的流体通道中。 激光询问区域可用于评估排序的有效性或准确性，以及在排序过程中控制或调整排序参数。
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公开(公告)号：US20140034555A1
公开(公告)日：2014-02-06
申请号：US13507830
申请日：2012-08-01
Applicant: John S. Foster , Daryl W. Grummitt
Inventor： John S. Foster , Daryl W. Grummitt
IPC: B07B1/00
CPC classification number: G01N15/1463 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0454 , B07C5/3425 , G01N15/1404 , G01N15/1425 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/1413 , G01N2015/149
Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.
Abstract translation: 一种使用粒子操纵级和多个激光询问区的基于MEMS的粒子操纵系统。 激光询问区域可用于评估粒子操纵阶段的有效性或准确性。 在一个示例性实施例中，颗粒操纵阶段是微制造的翼片式流体阀，其从流体流中的非目标颗粒排序目标颗粒。 激光询问阶段在翼片式分选阀的输入和输出处设置在微细加工的流体通道中。 激光询问区域可用于评估排序的有效性或准确性，以及在排序过程中控制或调整排序参数。
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公开(公告)号：US20120255373A1
公开(公告)日：2012-10-11
申请号：US13506892
申请日：2012-05-23
Applicant: John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
Inventor： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
IPC: G01N1/28
CPC classification number: C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
Abstract: A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
Abstract translation: 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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