知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

8 records (took 0.018 seconds)

    Fused 1,3,5-triazines
    7.
    发明授权
    Fused 1,3,5-triazines 失效
    熔融1,3,5-三嗪

    公开(公告)号：US4499269A

    公开(公告)日：1985-02-12

    申请号：US486795

    申请日：1983-04-20

    Applicant: Colin Bennion ,  David Robinson

    Inventor： Colin Bennion ,  David Robinson

    IPC: A61K31/53 ,  A61P37/06 ,  C07D277/82 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

    CPC classification number: C07D487/04 ,  C07D277/82 ,  C07D513/04

    Abstract: There are described compounds of formula I, ##STR1## in which X is O, S or N--R.sub.7,each Y, which may be the same or different, is H, OH, alkyl C1-C8, alkoxy C1-C8 or halogen,n is an integer from 1 to 4 inclusive,R and R.sub.1, which may be the same or different, are each H; alkanoyl C2-C8 or a group R.sub.4 in which R.sub.4 is alkyl C1-C8 optionally substituted by phenyl; or is cycloalkyl C5 or C6; or is a group of formula XVI, ##STR2## in which W and Z, which may be the same or different, are each H, OH, alkoxy C1-C8, phenyl-alkoxy C7 to C10, alkyl C1-C8, halogen, --NR.sub.2 R.sub.3, --COOR.sub.2, NO.sub.2, alkanoyloxy C2-C8, or --OCH.sub.2 CH.sub.2 NR.sub.2 R.sub.3, andR.sub.2, R.sub.3 and R.sub.7, which may be the same or different, are each H or alkyl C1-C8,provided that when X is N--R.sub.7 and R is H, then R.sub.1 is not (a) H when any Y groups are H, alkyl C1-C8, alkoxy C1-C8 or halogen, or (b) unsubstituted phenyl when all Y groups are H,and pharmaceutically acceptable salts thereof.There is also described the formulation and use of the compounds as pharmaceuticals, and processes for their production.

    Abstract translation: 描述了式I的化合物，其中X是O，S或N-R7，每个Y可以相同或不同，是H，OH，烷基C1-C8，烷氧基C1-C8或 卤素，n为1〜4的整数，R和R 1可以相同或不同，分别为H; 烷酰基C 2 -C 8或其中R 4为任选被苯基取代的C 1 -C 8烷基的基团R 4; 或者是环烷基C5或C6; 或者是一组式XVI，其中W和Z可以相同或不同，各自为H，OH，烷氧基C1-C8，苯基 - 烷氧基C7-C10，烷基C1-C8，卤素 ，-NR2R3，-COOR2，NO2，烷酰氧基C2-C8或-OCH2CH2NR2R3，R2，R3和R7可以相同或不同，分别为H或C1-C8烷基，条件是当X为N-R7 并且R为H时，当任何Y基团为H，烷基C1-C8，烷氧基C1-C8或卤素时，R1不为（a）H，或（b）当所有Y基团为H时，未取代的苯基及其药学上可接受的盐 。 还描述了化合物作为药物的制剂和用途及其生产方法。

Patent Agency Ranking