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公开(公告)号：US08394275B2
公开(公告)日：2013-03-12
申请号：US12811158
申请日：2008-12-16
IPC分类号： B01D15/08
CPC分类号： B01D15/14 , B01D15/22 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , Y10T29/49826
摘要： A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.
摘要翻译： 制备液相色谱装置的方法包括将两个内部导管插入中间管中，将中间管插入外管中，在中间管与至少一个内管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。
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公开(公告)号：US08409443B2
公开(公告)日：2013-04-02
申请号：US12595344
申请日：2008-04-10
CPC分类号： B01L3/50825 , B01L3/5021 , B01L2200/026 , B01L2200/142 , B01L2300/0858 , Y10T137/0318 , Y10T137/7869 , Y10T137/86187 , Y10T436/25375 , Y10T436/255
摘要： A device for limiting sample evaporation. The device has a vessel body having a body exterior surface and at least one body interior surface. The at least one body interior surface has one or more walls defining a first chamber, a second chamber and a conduit means. The first chamber has a first chamber opening for receiving at least one of the groups selected from a sample and a sample dispensing device. The first chamber opening defines the border of the body exterior surface and the body interior surface. The conduit means is in communication with the first chamber and the second chamber for receiving at least one of the group consisting of sample from said first chamber, a sample from a sample dispensing device and a sample dispensing device passing through or into the conduit means for placing the sample in the conduit means or into the second chamber. The second chamber is in communication with the conduit means for receiving and containing the sample from at least one of the group selected from the sample dispensing device and conduit means. The conduit means is arranged such that the sample in the second chamber is substantially isolated from the atmosphere to limit sample evaporation in the second chamber as the sample is contained therein.
摘要翻译： 用于限制样品蒸发的装置。 该装置具有容器主体，其具有主体外表面和至少一个主体内表面。 所述至少一个主体内表面具有限定第一室，第二室和导管装置的一个或多个壁。 第一室具有用于接收从样品和样品分配装置中选择的至少一个组的第一室开口。 第一腔室开口限定身体外表面和身体内表面的边界。 导管装置与第一腔室和第二腔室连通，用于接收来自所述第一腔室的样品，来自样品分配装置的样品和通过或进入导管装置的样品分配装置中的至少一个， 将样品放置在导管装置中或进入第二室。 第二室与用于从选自样品分配装置和导管装置中的组中的至少一个接收和容纳样品的导管装置连通。 管道装置被布置成使得第二室中的样品基本上与大气隔离，以在样品被包含在第二室中时限制第二室中的样品蒸发。
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3.发明申请Methods, Compositions and Devices For Performing Ionization Desorption on Silicon Derivatives 审中-公开用于在硅衍生物上进行电离解吸的方法，组合物和装置公开(公告)号：US20080305555A1
公开(公告)日：2008-12-11
申请号：US12063093
申请日：2006-08-16
CPC分类号： H01J49/04 , B01L3/5085 , Y10T436/24
摘要： A device for the presentation of samples for MALDI or DIOS ion source, comprising a semiconductor wafer body having at least one first surface and at least one second surface, the first surface being chemically modified to repel said aqueous sample toward said second surface.
摘要翻译： 用于呈现用于MALDI或DIOS离子源的样品的装置，包括具有至少一个第一表面和至少一个第二表面的半导体晶片体，所述第一表面经化学修饰以将所述水性样品排斥到所述第二表面。
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公开(公告)号：US08496818B2
公开(公告)日：2013-07-30
申请号：US11576385
申请日：2004-10-07
CPC分类号： B01D15/22 , G01N30/02 , G01N30/30 , G01N30/6091 , G01N30/7266
摘要： A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.
摘要翻译： 高压液相色谱（HPLC）毛细管柱装置，用于处理具有容纳填充毛细管柱的盒的HPLC样品的系统和方法; 用于样品流体的至少一个到毛细管柱的入口连接; 以及用于样品流体的来自毛细管柱的至少一个出口连接。 出口连接能够容纳用于雾化样品流体的喷嘴或用于将样品流体从喷嘴塔输送到喷嘴的输送管。 入口连接使得能够通过设置在盒壳体内的电气连接向毛细管柱供应电力; 并且用于蒸发样品液体的气体从用于样品流体的毛细管柱通过盒壳体内的气体供给管线供应到至少一个出口连接。 可以通过热连接来控制样品液体的温度。
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5.发明申请公开(公告)号：US20100018928A1
公开(公告)日：2010-01-28
申请号：US11719381
申请日：2005-11-16
CPC分类号： G01N30/603 , B01D15/22 , B01J20/283
摘要： Embodiments of the present invention feature a device (11) for performing separations, methods of making and using such device (11). The device (11) includes a tubular member (13) having an exterior surface (17) and an interior surface (19). The interior surface (19) defines a chamber (25) having an outlet end (23) and an inlet end (21) for containing a separation media (15). The chamber (25) has a length dimension extending between the inlet end (21) and the outlet end (23), and at least one width dimension. A separation media (15) is constructed and arranged in a packing of particles in the chamber wherein the particles of the separation media (15) proximal to at least one of the inlet end (21) or outlet end (23) are fused to retain the separation media (15).
摘要翻译： 本发明的实施例的特征在于用于执行分离的装置（11），以及制造和使用这种装置（11）的方法。 装置（11）包括具有外表面（17）和内表面（19）的管状构件（13）。 内表面（19）限定了具有出口端（23）和用于容纳分离介质（15）的入口端（21）的腔室（25）。 腔室（25）具有在入口端（21）和出口端（23）之间延伸的长度尺寸和至少一个宽度尺寸。 分离介质（15）被构造并布置在腔室中的颗粒填料中，其中分离介质（15）的接近入口端（21）或出口端（23）中的至少一个的颗粒被熔合以保持 分离介质（15）。
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公开(公告)号：US20080257835A1
公开(公告)日：2008-10-23
申请号：US11573314
申请日：2005-08-17
申请人： Christopher C. Benevides , Jonathan L. Belanger , Marianna Kele , Thomas H. Walter , Raymond P. Fisk
发明人： Christopher C. Benevides , Jonathan L. Belanger , Marianna Kele , Thomas H. Walter , Raymond P. Fisk
CPC分类号： B01D15/125 , B01D15/22 , G01N30/14 , G01N2030/322 , G01N2030/528
摘要： Embodiments of the present invention are directed to devices, methods and apparatus for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. In one embodiment directed to a device, the invention includes a body (13) having a first surface (17) and a second surface (19) and at least one wall (23). At least one of the first surface (17) and second surface (19) is for receiving in sealing engagement a first conduit means. The remaining first surface (17) or second surface (19) is for engaging a column or a second conduit (19). The at least one wall (23) extends between the first surface (17) and the second surface (19). The body (13) has at least one opening (25) extending from the first surface (17) to the second surface (19) defining a chamber for receiving a solid phase separation media assembly (15). The device further includes a solid phase separation media assembly (15) within the chamber formed in the opening of the body between the first surface (17) and the second surface (19). The solid phase separation media assembly (15) is for removing particulates and undesired materials of a fluid flowing through the chamber. The body is constructed and arranged to fit in a body fitting to be attached to a column or which body fitting is part of an assembly for communicating with an column or a detector.
摘要翻译： 本发明的实施方案涉及用于进行分离的装置，方法和装置，其中微粒从流入塔的流体流分离或除去。 在针对装置的一个实施例中，本发明包括具有第一表面（17）和第二表面（19）以及至少一个壁（23）的主体（13）。 第一表面（17）和第二表面（19）中的至少一个用于以密封接合方式接收第一导管装置。 剩余的第一表面（17）或第二表面（19）用于接合柱或第二导管（19）。 所述至少一个壁（23）在所述第一表面（17）和所述第二表面（19）之间延伸。 主体（13）具有从第一表面（17）延伸到第二表面（19）的至少一个开口（25），其限定用于容纳固相分离介质组件（15）的室。 该装置还包括在第一表面（17）和第二表面（19）之间形成在主体的开口中的室内的固相分离介质组件（15）。 固相分离介质组件（15）用于去除流过室的流体的微粒和不期望的材料。 主体被构造和布置成适合于附接到柱的主体配件中，或者哪个主体配件是用于与柱或检测器通信的组件的一部分。
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公开(公告)号：US20080197078A1
公开(公告)日：2008-08-21
申请号：US11576385
申请日：2004-10-07
IPC分类号： B01D15/26
CPC分类号： B01D15/22 , G01N30/02 , G01N30/30 , G01N30/6091 , G01N30/7266
摘要： A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.
摘要翻译： 高压液相色谱（HPLC）毛细管柱装置，用于处理具有容纳填充毛细管柱的盒的HPLC样品的系统和方法; 用于样品流体的至少一个到毛细管柱的入口连接; 以及用于样品流体的来自毛细管柱的至少一个出口连接。 出口连接能够容纳用于雾化样品流体的喷嘴或用于将样品流体从喷嘴塔输送到喷嘴的输送管。 入口连接使得能够通过设置在盒壳体内的电气连接向毛细管柱供应电力; 并且用于蒸发样品液体的气体从用于样品流体的毛细管柱通过盒壳体内的气体供给管线供应到至少一个出口连接。 可以通过热连接来控制样品液体的温度。
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公开(公告)号：US20100132799A1
公开(公告)日：2010-06-03
申请号：US12595344
申请日：2008-04-10
IPC分类号： E03B11/00
CPC分类号： B01L3/50825 , B01L3/5021 , B01L2200/026 , B01L2200/142 , B01L2300/0858 , Y10T137/0318 , Y10T137/7869 , Y10T137/86187 , Y10T436/25375 , Y10T436/255
摘要： A device for limiting sample evaporation. The device has a vessel body having a body exterior surface and at least one body interior surface. The at least one body interior surface has one or more walls defining a first chamber, a second chamber and a conduit means. The first chamber has a first chamber opening for receiving at least one of the groups selected from a sample and a sample dispensing device. The first chamber opening defines the border of the body exterior surface and the body interior surface. The conduit means is in communication with the first chamber and the second chamber for receiving at least one of the group consisting of sample from said first chamber, a sample from a sample dispensing device and a sample dispensing device passing through or into the conduit means for placing the sample in the conduit means or into the second chamber. The second chamber is in communication with the conduit means for receiving and containing the sample from at least one of the group selected from the sample dispensing device and conduit means. The conduit means is arranged such that the sample in the second chamber is substantially isolated from the atmosphere to limit sample evaporation in the second chamber as the sample is contained therein.
摘要翻译： 用于限制样品蒸发的装置。 该装置具有容器主体，其具有主体外表面和至少一个主体内表面。 所述至少一个主体内表面具有限定第一室，第二室和导管装置的一个或多个壁。 第一室具有用于接收从样品和样品分配装置中选择的至少一个组的第一室开口。 第一腔室开口限定身体外表面和身体内表面的边界。 导管装置与第一腔室和第二腔室连通，用于接收来自所述第一腔室的样品，来自样品分配装置的样品和通过或进入导管装置的样品分配装置中的至少一个， 将样品放置在导管装置中或进入第二室。 第二室与用于从选自样品分配装置和导管装置中的组中的至少一个接收和容纳样品的导管装置连通。 管道装置被布置成使得第二室中的样品基本上与大气隔离，以在样品被包含在第二室中时限制样品在第二室中的蒸发。
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公开(公告)号：US20090321356A1
公开(公告)日：2009-12-31
申请号：US12282225
申请日：2007-03-19
CPC分类号： G01N30/606 , G01N30/6026 , G01N30/6095
摘要： A high-performance liquid-chromatography apparatus includes a substrate that defines a separation column in fluidic communication with an inlet port of the processing unit. The processing unit is formed of sintered inorganic particles. The apparatus also includes a pump that delivers a solvent to the inlet port at a pressure sufficient for high-performance liquid-chromatography.
摘要翻译： 高效液相色谱装置包括限定与处理单元的入口流体连通的分离塔的基板。 处理单元由烧结无机颗粒形成。 该设备还包括泵，其以足以用于高效液相色谱的压力将溶剂输送到入口。
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公开(公告)号：US08845892B2
公开(公告)日：2014-09-30
申请号：US11573314
申请日：2005-08-17
申请人： Christopher C. Benevides , Jonathan L. Belanger , Marianna Kele , Thomas H. Walter , Raymond P. Fisk
发明人： Christopher C. Benevides , Jonathan L. Belanger , Marianna Kele , Thomas H. Walter , Raymond P. Fisk
CPC分类号： B01D15/125 , B01D15/22 , G01N30/14 , G01N2030/322 , G01N2030/528
摘要： Embodiments of the present invention are directed to devices, methods and apparatus for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. In one embodiment directed to a device, the invention includes a body (13) having a first surface (17) and a second surface (19) and at least one wall (23). At least one of the first surface (17) and second surface (19) is for receiving in sealing engagement a first conduit means. The remaining first surface (17) or second surface (19) is for engaging a column or a second conduit (19). The at least one wall (23) extends between the first surface (17) and the second surface (19). The body (13) has at least one opening (25) extending from the first surface (17) to the second surface (19) defining a chamber for receiving a solid phase separation media assembly (15). The device further includes a solid phase separation media assembly (15) within the chamber formed in the opening of the body between the first surface (17) and the second surface (19). The solid phase separation media assembly (15) is for removing particulates and undesired materials of a fluid flowing through the chamber. The body is constructed and arranged to fit in a body fitting to be attached to a column or which body fitting is part of an assembly for communicating with an column or a detector.
摘要翻译： 本发明的实施方案涉及用于进行分离的装置，方法和装置，其中微粒从流入塔的流体流分离或除去。 在针对装置的一个实施例中，本发明包括具有第一表面（17）和第二表面（19）以及至少一个壁（23）的主体（13）。 第一表面（17）和第二表面（19）中的至少一个用于以密封接合方式接收第一导管装置。 剩余的第一表面（17）或第二表面（19）用于接合柱或第二导管（19）。 所述至少一个壁（23）在所述第一表面（17）和所述第二表面（19）之间延伸。 主体（13）具有从第一表面（17）延伸到第二表面（19）的至少一个开口（25），其限定用于容纳固相分离介质组件（15）的室。 该装置还包括在第一表面（17）和第二表面（19）之间形成在主体的开口中的室内的固相分离介质组件（15）。 固相分离介质组件（15）用于去除流过室的流体的微粒和不期望的材料。 主体被构造和布置成适合于附接到柱的主体配件中，或者哪个主体配件是用于与柱或检测器通信的组件的一部分。
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