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公开(公告)号：US20140302041A1
公开(公告)日：2014-10-09
申请号：US14127415
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC: C07K16/30 , G01N33/574 , C07K16/40
CPC classification number: C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9，SEQ ID NO：10和SEQ ID NO：11结合Ax1的细胞外结构域。
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公开(公告)号：US20140227283A1
公开(公告)日：2014-08-14
申请号：US14127416
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC: C07K16/28 , G01N33/68 , G01N33/574
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9 and SEQ ID NO: 10.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9和SEQ ID NO：10与Ax1的细胞外结构域结合。
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3.发明申请Peptide Derivatives for Biofunctionalization of Silicon Substrates and Their Applications 有权用于硅衬底生物功能化的肽衍生物及其应用公开(公告)号：US20130131314A1
公开(公告)日：2013-05-23
申请号：US13695913
申请日：2011-05-05
Applicant: Csilla Gergely , Elias Estephan , Marie-Belle Saab , Christian Larroque , Frédéric Cuisinier
Inventor： Csilla Gergely , Elias Estephan , Marie-Belle Saab , Christian Larroque , Frédéric Cuisinier
CPC classification number: C07K17/14 , C07K7/08 , G01N33/54353 , G01N33/551
Abstract: The present invention relates to the use of a peptide consisting of 5 to 30 amino acid residues comprising an amino acid sequence selected from LLADTTHHRPWT (SEQ ID NO: 1), SPGLSLVSHMQT (SEQ ID NO: 2), and the sequences presenting at least 80% identity with SEQ ID NO: 1 or SEQ ID NO: 2, for the funcfionalization of silicon substrate. The present invention also relates to the specific peptides as such, and to silicon substrates functionalized by the adsorption on their surface of such specific peptides. Finally, the present invention is also directed to a process for the preparation of such functionalized silicon substrates, and to articles comprising a silicon substrate according to the invention.
Abstract translation: 本发明涉及由包含选自LLADTTHHRPWT（SEQ ID NO：1），SPGLSLVSHMQT（SEQ ID NO：2））的氨基酸序列的5至30个氨基酸残基组成的肽的用途，以及呈现至少80 与SEQ ID NO：1或SEQ ID NO：2的同一性，用于硅衬底的功能化。 本发明还涉及特定的肽，以及通过在其表面上吸附这些特定肽而官能化的硅底物。 最后，本发明还涉及制备这种官能化硅衬底的方法以及包含根据本发明的硅衬底的制品。
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Patent Agency Ranking
公开(公告)号：US09249228B2
公开(公告)日：2016-02-02
申请号：US14127415
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC: C07K16/28 , C07K16/30 , A61K39/395 , C07K16/40 , G01N33/574 , A61K39/00
CPC classification number: C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9，SEQ ID NO：10和SEQ ID NO：11结合Ax1的细胞外结构域。
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5.发明申请公开(公告)号：US20110303318A1
公开(公告)日：2011-12-15
申请号：US13158772
申请日：2011-06-13
Applicant: Ludovic Nicolas , Gwenaëlle Bierce-Argy , Sandrine Houee , Christian Larroque , Alper Caliskan
Inventor： Ludovic Nicolas , Gwenaëlle Bierce-Argy , Sandrine Houee , Christian Larroque , Alper Caliskan
CPC classification number: B32B1/08 , B32B5/026 , B32B25/08 , B32B25/14 , B32B27/308 , B32B2262/0261 , B32B2262/0276 , B32B2307/306 , B32B2307/50 , B32B2307/732 , C08L31/04 , C08L33/08 , F02M35/10321 , F02M35/10334 , F16L11/085 , Y10T428/1393
Abstract: The present invention relates to a pipe usable for an air intake circuit of a motor vehicle engine, and to this air intake circuit in particular for the intake of air at the outlet of a turbocompressor that comprises at least one such pipe.This pipe (1) comprises at least one inner elastomer layer (10), one outer elastomer layer (16), one intermediate elastomer layer (12) and one reinforcing structure (14) which is situated between the intermediate and outer layers and which comprises yarns based on an aliphatic polyester, such as a PET, each intermediate and outer layer being formed from a composition based on at least one acrylate copolymer (ACM).According to the invention, said composition is crosslinked by means of a system chosen from the group consisting of those based on at least one soap combined with sulfur, with a urea derivative and those based on a thiadiazole.
Abstract translation: 本发明涉及一种可用于机动车辆发动机的进气回路的管道，特别涉及用于在包括至少一个这种管道的涡轮压缩机的出口处吸入空气的该进气回路。 该管（1）包括位于中间层和外层之间的至少一个内部弹性体层（10），一个外部弹性体层（16），一个中间弹性体层（12）和一个加强结构（14），并且包括 基于脂肪族聚酯（例如PET）的纱线，每个中间层和外层由基于至少一种丙烯酸酯共聚物（ACM）的组合物形成。 根据本发明，所述组合物通过选自基于至少一种与硫结合的皂的那些系统，与尿素衍生物和基于噻二唑的那些系统进行交联。
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6.发明授权Peptide derivatives for biofunctionalization of silicon substrates and their applications 有权用于硅衬底生物功能化的肽衍生物及其应用公开(公告)号：US09102716B2
公开(公告)日：2015-08-11
申请号：US13695913
申请日：2011-05-05
Applicant: Csilla Gergely , Elias Estephan , Marie-belle Saab , Christian Larroque , Frédéric Cuisinier
Inventor： Csilla Gergely , Elias Estephan , Marie-belle Saab , Christian Larroque , Frédéric Cuisinier
IPC: C07K17/14 , C07K7/08 , G01N33/543 , G01N33/551
CPC classification number: C07K17/14 , C07K7/08 , G01N33/54353 , G01N33/551
Abstract: The present invention relates to the use of a peptide consisting of 5 to 30 amino acid residues comprising an amino acid sequence selected from LLADTTHHRPWT (SEQ ID NO: 1), SPGLSLVSHMQT (SEQ ID NO: 2), and the sequences presenting at least 80% identity with SEQ ID NO: 1 or SEQ ID NO: 2, for the functionalization of silicon substrate. The present invention also relates to the specific peptides as such, and to silicon substrates functionalized by the adsorption on their surface of such specific peptides. Finally, the present invention is also directed to a process for the preparation of such functionalized silicon substrates, and to articles comprising a silicon substrate according to the invention.
Abstract translation: 本发明涉及由包含选自LLADTTHHRPWT（SEQ ID NO：1），SPGLSLVSHMQT（SEQ ID NO：2））的氨基酸序列的5至30个氨基酸残基组成的肽的用途，以及呈现至少80 与SEQ ID NO：1或SEQ ID NO：2的同一性，用于硅底物的官能化。 本发明还涉及特定的肽，以及通过在其表面上吸附这些特定肽而官能化的硅底物。 最后，本发明还涉及制备这种官能化硅衬底的方法以及包含根据本发明的硅衬底的制品。
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公开(公告)号：US09409988B2
公开(公告)日：2016-08-09
申请号：US14127416
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9 and SEQ ID NO: 10.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9和SEQ ID NO：10与Ax1的细胞外结构域结合。
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8.发明授权Pipe for the air intake circuit of a motor vehicle engine, and circuit incorporating the same 有权用于机动车辆发动机的进气回路的管道，以及并入其的回路公开(公告)号：US08449961B2
公开(公告)日：2013-05-28
申请号：US13158772
申请日：2011-06-13
Applicant: Ludovic Nicolas , Gwenaëlle Bierce-Argy , Sandrine Houee , Christian Larroque , Alper Caliskan
Inventor： Ludovic Nicolas , Gwenaëlle Bierce-Argy , Sandrine Houee , Christian Larroque , Alper Caliskan
IPC: B29D22/00
CPC classification number: B32B1/08 , B32B5/026 , B32B25/08 , B32B25/14 , B32B27/308 , B32B2262/0261 , B32B2262/0276 , B32B2307/306 , B32B2307/50 , B32B2307/732 , C08L31/04 , C08L33/08 , F02M35/10321 , F02M35/10334 , F16L11/085 , Y10T428/1393
Abstract: The present invention relates to a pipe usable for an air intake circuit of a motor vehicle engine, and to this air intake circuit in particular for the intake of air at the outlet of a turbocompressor that comprises at least one such pipe.This pipe (1) comprises at least one inner elastomer layer (10), one outer elastomer layer (16), one intermediate elastomer layer (12) and one reinforcing structure (14) which is situated between the intermediate and outer layers and which comprises yarns based on an aliphatic polyester, such as a PET, each intermediate and outer layer being formed from a composition based on at least one acrylate copolymer (ACM).According to the invention, said composition is crosslinked by means of a system chosen from the group consisting of those based on at least one soap combined with sulfur, with a urea derivative and those based on a thiadiazole.
Abstract translation: 本发明涉及一种可用于机动车辆发动机的进气回路的管道，特别涉及用于在包括至少一个这种管道的涡轮压缩机的出口处吸入空气的该进气回路。 该管（1）包括位于中间层和外层之间的至少一个内部弹性体层（10），一个外部弹性体层（16），一个中间弹性体层（12）和一个加强结构（14），并且包括 基于脂肪族聚酯（例如PET）的纱线，每个中间层和外层由基于至少一种丙烯酸酯共聚物（ACM）的组合物形成。 根据本发明，所述组合物通过选自基于至少一种与硫结合的皂的那些系统，与尿素衍生物和基于噻二唑的那些系统进行交联。
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