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公开(公告)号：US09249228B2
公开(公告)日：2016-02-02
申请号：US14127415
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC: C07K16/28 , C07K16/30 , A61K39/395 , C07K16/40 , G01N33/574 , A61K39/00
CPC classification number: C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9，SEQ ID NO：10和SEQ ID NO：11结合Ax1的细胞外结构域。
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公开(公告)号：US20140302041A1
公开(公告)日：2014-10-09
申请号：US14127415
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC: C07K16/30 , G01N33/574 , C07K16/40
CPC classification number: C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9，SEQ ID NO：10和SEQ ID NO：11结合Ax1的细胞外结构域。
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公开(公告)号：US20140227283A1
公开(公告)日：2014-08-14
申请号：US14127416
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC: C07K16/28 , G01N33/68 , G01N33/574
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9 and SEQ ID NO: 10.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9和SEQ ID NO：10与Ax1的细胞外结构域结合。
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公开(公告)号：US09409988B2
公开(公告)日：2016-08-09
申请号：US14127416
申请日：2012-06-22
Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
Inventor： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872
Abstract: The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9 and SEQ ID NO: 10.
Abstract translation: 本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。 更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。 所述单克隆抗体通过SEQ ID NO：9和SEQ ID NO：10与Ax1的细胞外结构域结合。
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