公开(公告)号：US20250059504A1

公开(公告)日：2025-02-20

申请号：US18916118

申请日：2024-10-15

Applicant: UNIVERSITE DE BORDEAUX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT D'OPTIQUE THEORIQUE ET APPLIQUEE

Inventor： MAXIME FEYEUX ,  KEVIN ALESSANDRI ,  PIERRE NASSOY ,  LAURENT COGNET ,  GAËLLE RECHER ,  ERWAN BEZARD

IPC: C12N5/00 ,  C12M1/00 ,  C12M1/12 ,  C12N5/074

Abstract: The invention relates to a cellular microcompartment comprising successively, organized around a lumen, at least one layer of pluripotent cells, an extracellular matrix layer and an outer hydrogel layer. The invention also relates to processes for preparing such cellular microcompartments.

公开(公告)号：US12227550B2

公开(公告)日：2025-02-18

申请号：US17847380

申请日：2022-06-23

Applicant: VIB VZW ,  UNIVERSITEIT GENT ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITÉ DE MONTPELLIER ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER

Inventor： Jan Tavernier ,  Jennyfer Bultinck ,  Frank Peelman ,  Gilles Uze

IPC: C07K14/525 ,  A61K38/00 ,  A61K39/00 ,  C07K16/28 ,  C07K16/32

Abstract: The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is specifically delivered to target cells. Preferably, said modified cytokine is a single chain variant of the TNF superfamily, even more preferably, one or more of the chains can-y one or more mutations, resulting in a low affinity to the receptor, wherein said mutant cytokine is specifically delivered to target cells. The targeting is realized by fusion of the modified cytokine of the TNF superfamily to a targeting moiety, preferably an antibody or antibody-like molecule. The invention relates further to the use of such targeted modified cytokine of the TNF superfamily to treat diseases.

公开(公告)号：US20250055418A1

公开(公告)日：2025-02-13

申请号：US18722945

申请日：2022-12-16

Applicant: ELECTRICITE DE FRANCE ,  INSTITUT PHOTOVOLTAIQUE D'ILE DE FRANCE (IPVF) ,  TOTALENERGIES ONETECH ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  ECOLE POLYTECHNIQUE

Inventor： Jean-Baptiste PUEL ,  Arthur JULIEN ,  Jean-François GUILLEMOLES

IPC: H02S50/10 ,  G01R21/06

Abstract: A process for maximum power point tracking of a photovoltaic module, which includes monitoring the module's degradation by: for a periodicity n1δt0 with n1>1 constant or variable, steps of measuring parameters I and V of the module for points offset in voltage voltage VMPP+α and VMPP−β over the curve I(V) relative to the maximum power point MPP, calculating the slope dI/dV+ at the point VMPP+α and the slope dI/dV− at the point and VMPP−β and recording of the data with the MPP; for a periodicity n2δt0 with n2≥n1 of > of steps of measuring values I and V by sweeping the curve I(V) and calculating and storing the module's parameters and values; one or several steps of calculating, tracing and displaying of (p/2)
curves of data pairs based on p measured and calculated parameters; and one or more steps of detecting degradation from the measured and calculated parameters.

公开(公告)号：US20250044243A1

公开(公告)日：2025-02-06

申请号：US18717887

申请日：2022-12-02

Applicant: ECOLE POLYTECHNIQUE ,  ECOLE NATIONALE SUPERIEURE DES TECHNIQUES AVANCEES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Philippe ZEITOUN

IPC: G01N23/041 ,  G01N23/046

Abstract: An imaging method for determining a parameter δ of real and imaginary parts of a sample complex optical index; the method using an X-ray source to illuminate the sample, a perforated grating arranged between the sample and the detector, and a signal processing unit; the method performing measurement while illuminating the sample, the X-rays reaching the detector forming a spot for each grating hole; for each measurement and for each grating hole, analysing the grating spot by determining a spot barycenter using a centroid-finding technique, determining an offset of the barycenter relative to a reference barycenter and determining a local phase variation via the offset of the barycenter, determining an amplitude of the X-rays forming the spot and determining a local attenuation relative to a reference amplitude, determining the parameter δ on the basis of the local phase variation, and determining the imaginary part β via the local attenuation.

公开(公告)号：US20250042854A1

公开(公告)日：2025-02-06

申请号：US18710330

申请日：2022-11-15

Applicant: Ecole Nationale Supérieure de Chimie de Rennes ,  Institut National des Sciences Appliquées ,  Universite de Rennes ,  University of California, San Diego ,  Centre National de la Recherche Scientifique

Inventor： Marc MAUDUIT ,  Jennifer MORVAN ,  Jakub TALCIK ,  Rodolphe JAZZAR ,  Guy BERTRAND ,  Mohand-Ameziane MELAIMI ,  Melinda Rachel SERRATO

IPC: C07D209/56 ,  B01J31/22 ,  C07D209/96 ,  C07F7/08 ,  C07F7/18 ,  C07F15/00

Abstract: The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

公开(公告)号：US20250034205A1

公开(公告)日：2025-01-30

申请号：US18693250

申请日：2022-10-07

Applicant: UNIVERSITÉ GRENOBLE ALPES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

Inventor： André VERDEL ,  Leïla TODESCHINI ,  Daniel PERAZZA

IPC: C07K1/22 ,  C07K14/39

Abstract: A method for purifying a protein of interest includes the preparation of a fusion protein in which this protein of interest is fused to a protein tag having the protein Mmi1 of a microorganism of the genus Schizosaccharomyces or a fragment thereof, the bringing into contact of this fusion protein with a ribonucleic acid molecule containing at least one motif of UNAAAC nucleotide sequence, so as to allow the affinity binding of the protein tag with this ribonucleic acid molecule, and the recovery of the protein of interest.

公开(公告)号：US20250034194A1

公开(公告)日：2025-01-30

申请号：US18714018

申请日：2022-11-29

Applicant: UNIVERSITE DE PICARDIE JULES VERNE ,  UNIVERSITE PARIS EST CRETEIL VAL DE MARNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： Anne WADOUACHI ,  Dulce PAPY GARCIA ,  Gwladys POURCEAU ,  Sandrine CHANTEPIE

IPC: C07H15/04 ,  A61K31/7032

Abstract: The present disclosure relates to lipid anionic oligosaccharides and to the uses thereof in medicine, especially in the treatment of the pathologies associated with abnormal hyperphosphorylation of tau protein, such as Alzheimer's disease.

公开(公告)号：US20250033001A1

公开(公告)日：2025-01-30

申请号：US18844023

申请日：2023-03-02

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE ,  ECOLE NORMALE SUPERIEURE ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

Inventor： Pierre TIGNOL ,  Anne-Laurence DUPONT ,  Vanessa PIMENTA ,  Christian SERRE ,  Bertrand LAVEDRINE

IPC: B01D71/10 ,  B01D53/22 ,  B01D67/00 ,  B01D69/14

Abstract: A method for preparing a porous membrane, comprising the following steps of: a—preparing an aqueous mixture comprising a dispersion of fibres derived from an organic material in water, a solid organic binder and porous solid particles suspended in water; b—leaving the obtained aqueous mixture comprising the fibres, the organic binder and the porous solid particles under stirring for at least 10 min at room temperature; c—vacuum filtering the mixture and recovering a composite material; and d—pressing said composite material obtained in step c—to form a porous membrane.

公开(公告)号：US12210076B2

公开(公告)日：2025-01-28

申请号：US17043712

申请日：2019-03-27

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  ECOLE CENTRALE DE MARSEILLE ,  UNIVERSITE D'AIX-MARSEILLE (AMU)

Inventor： Abdeddaim Redha ,  Anne-Lise Adenot-Engelvin ,  Marc Dubois ,  Stefan Enoch ,  Nicolas Mallejac ,  Zo Raolison ,  Pierre Sabouroux ,  Alexandre Vignaud

IPC: G01R33/28 ,  G01R33/565

Abstract: The invention relates to a material for use as a pad in high field and/or very high field magnetic resonance imaging instrument, comprising at least one polar solvent having a melting point of 14° C. to 50° C., a dispersant and a dielectric charge. The invention relates also to a pad used in field of high field and/or very high field magnetic resonance imaging made of at least such a material.

公开(公告)号：US12206039B2

公开(公告)日：2025-01-21

申请号：US17782987

申请日：2020-12-10

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT POLYTECHNIQUE DE GRENOBLE ,  UNIVERSITE SAVOIE MONT BLANC ,  UNIVERSITE GRENOBLE ALPES

Inventor： Christopher Bauerle ,  Jean-François Roux ,  Giorgos Georgiou

IPC: H01L31/12 ,  H01L31/0224 ,  H01L31/0304 ,  H01L31/0384 ,  H01L31/18

Abstract: A photoconductive transducer intended to generate or detect waves in the terahertz frequency domain or in the picosecond pulse domain is provided. The transducer comprises a three-dimensional structure that includes, in this order, a first planar electrode, an array of nano-columns embedded in a layer of resist and a second planar electrode parallel to the first planar electrode. The design of the transducer increases the optical-to-terahertz conversion efficiency by means of photonic and plasmonic resonances and by means of high and homogeneous electric fields. The height of the nano-columns as well as the thickness of the resist range between 100 nanometres and 400 nanometres. The width of the nano-columns is between 100 nanometres and 400 nanometres, the distance between two adjacent nano-columns is between 300 nanometres and 500 nanometres, the nano-columns are made of a III-V semiconductor. The second electrode is transparent, so as to allow the transmission of a laser source towards the photo-absorbing nano-columns.