-
公开(公告)号：US08287703B2
公开(公告)日：2012-10-16
申请号：US12238023
申请日：2008-09-25
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
-
公开(公告)号：US07479211B2
公开(公告)日：2009-01-20
申请号：US10845434
申请日：2004-05-13
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , Y10T29/49002
摘要： A method of forming a biosensor is provided in accordance with the present invention. The method includes providing a metallized electrode support substrate and a sensor support, ablating the electrode support substrate to form electrodes, coupling the sensor support substrate to the electrode support substrate, and positioning spaced-apart electrically conductive tracks across the sensor support substrate so that each track is in electrical communication with one electrode.
摘要翻译： 根据本发明提供了形成生物传感器的方法。 该方法包括提供金属化电极支撑衬底和传感器支撑件，消融电极支撑衬底以形成电极，将传感器支撑衬底连接到电极支撑衬底，以及跨越传感器支撑衬底定位间隔开的导电轨迹， 轨道与一个电极电连通。
-
公开(公告)号：US06645359B1
公开(公告)日：2003-11-11
申请号：US09684257
申请日：2000-10-06
IPC分类号： G01N27327
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , Y10T29/49 , Y10T29/49002 , Y10T29/49007 , Y10T29/49117
摘要： A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
摘要翻译： 提供了一种生物传感器，其包括具有预定反应区的板元件和邻近反应区定位的凹部。 生物传感器还包括位于反应区上的试剂。 在优选的实施方案中，凹部限定反应区的至少一部分。
-
公开(公告)号：US5762770A
公开(公告)日：1998-06-09
申请号：US496939
申请日：1995-06-30
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/54
摘要： An electrochemical biosensor test strip that has a minimum volume blood sample requirement of about 9 microliters. The test strip has working and counter electrodes that are substantially the same size and made of the same electrically conducting material placed on a first insulating substrate. Overlaying the electrodes is a second insulating substrate, which includes a cutout portion that forms a reagent well. The cutout portion exposes a smaller area of the counter electrode than the working electrode. A reagent for analysis of an analyte substantially covers the exposed areas of working and counter electrodes in the reagent well. Overlaying the reagent well and affixed to the second insulating substrate is a spreading mesh that is impregnated with a surfactant. The small cutout portion of 4 millimeters by 4.2 millimeters, small mesh of 6 millimeters by 5.8 millimeters, and small amount of reagent, 4 microliters before drying, allow the test strip to analyze a whole blood sample of about 9 microliters.
摘要翻译： 电化学生物传感器测试条具有约9微升的最小体积血液样本要求。 测试条具有基本上相同尺寸并由放置在第一绝缘基板上的相同导电材料制成的工作对电极。 覆盖电极是第二绝缘基板，其包括形成试剂的切口部分。 切除部分暴露对电极的面积比工作电极的面积小。 用于分析分析物的试剂基本上覆盖试剂阱中的工作和对电极的暴露区域。 将试剂叠加并固定到第二绝缘基底上的是用表面活性剂浸渍的铺展网。 4毫米×4.2毫米的小切口部分，6毫米×5.8毫米的小网孔和少量试剂，干燥前4微升，允许测试条分析约9微升的全血样品。
-
公开(公告)号：US5165407A
公开(公告)日：1992-11-24
申请号：US682560
申请日：1991-04-09
申请人： George S. Wilson , Dilbir S. Bindra , Brian S. Hill , Daniel R. Thevenot , Robert Sternberg , Gerard Reach , Yanan Zhang
发明人： George S. Wilson , Dilbir S. Bindra , Brian S. Hill , Daniel R. Thevenot , Robert Sternberg , Gerard Reach , Yanan Zhang
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/1486 , C12Q1/00 , G01N27/30 , G01N27/416 , G01N33/487
CPC分类号： C12Q1/006 , A61B5/14865 , A61B5/6848
摘要： Implantable enzymatic sensors (25, 43, 44) for biochemicals such as glucose are provided having an ideal size and geometry for optional long term implantation and linear responses over the concentration ranges of interest. The sensors (25, 43, 44) include an elongated body (10, 26, 46) supporting an indicating electrode section having an appropriate enzyme immobilized thereon to present an enzymatic indicating surface (21, 33, 54). A permeable synthetic polymer membrane (24, 42, 56) is applied over the sensor body (10, 26, 46) to protect the enzyme and regulate diffusion of analyte therethrough, to ensure linearity of sensor response. The sensors (25, 43) are of flexible design and can be implanted using a catheter. Alternately, the sensor (44) includes an internal indicating electrode body (46) housed within an apertured, hollow needle (48). A holder (66) affixed to the needle (48) allows for easy manipulation and implantation of the sensor (44).
摘要翻译： 提供了用于生物化学品如葡萄糖的可植入酶传感器（25,43,44），其具有理想的尺寸和几何尺寸，用于在所关注的浓度范围内进行可选的长期植入和线性响应。 传感器（25,43,44）包括支撑指示电极部分的细长体（10,26,46），所述指示电极部分具有固定在其上的合适的酶以呈现酶指示表面（21,33,54）。 将可渗透的合成聚合物膜（24,42,56）施加在传感器主体（10,26,46）上以保护酶并调节分析物通过其的扩散，以确保传感器响应的线性。 传感器（25,43）具有柔性设计，并且可以使用导管植入。 或者，传感器（44）包括容纳在有孔的空心针（48）内的内部指示电极体（46）。 固定在针（48）上的支架（66）可以方便地操作和植入传感器（44）。
-
公开(公告)号：US08506775B2
公开(公告)日：2013-08-13
申请号：US10872008
申请日：2004-06-18
申请人： Nigel Anthony Surridge , Paul Douglas Walling , Melani Sullivan , Vladimir Svetnik , Brian S. Hill
发明人： Nigel Anthony Surridge , Paul Douglas Walling , Melani Sullivan , Vladimir Svetnik , Brian S. Hill
IPC分类号： C12M1/00
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A system for testing for analytes in a sample of biological fluid includes a test strip that defines a cavity for receiving the sample. At least two sets of electrodes are adjacent the sample cavity, including one for measuring one property of the sample, and another for measuring one or more other properties of the sample, such as temperature and/or the presence or magnitude of confounding variables. The measurements are combined to yield the desired result. At least one set of working and counter electrodes each have a plurality of elongated “fingers” interdigitated with those of the other electrode in the set. The gaps between fingers can be quite small, so that the two electrode sets together can operate in a small measurement volume of sample. Additional electrodes can be included that measure the presence or sufficiency of the sample, and additional traces on the strip can act as configuration identifiers.
摘要翻译： 用于测试生物流体样品中分析物的系统包括限定用于接收样品的空腔的测试条。 至少两组电极与样品腔相邻，包括一个用于测量样品的一个性质，另一组用于测量样品的一个或多个其他性质，如温度和/或混杂变量的存在或大小。 将测量结合以产生期望的结果。 至少一组工作电极和对电极各自具有与组中的另一电极的那些相互指向的多个细长“指状物”。 手指之间的间隙可以相当小，使得两个电极组合在一起可以在小的测量体积的样品中操作。 可以包括测量样品的存在或充分性的附加电极，并且条带上的附加痕迹可以用作配置标识符。
-
公开(公告)号：US07386937B2
公开(公告)日：2008-06-17
申请号：US11416497
申请日：2006-05-01
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.
摘要翻译： 提供制造生物传感器的方法。 该方法包括在基底上提供导电材料，并使用从基底的激光烧蚀部分地去除导电材料，使得小于90％的导电材料保留在基底上，并且由导电材料形成至少一个电极图案。 所述至少一个电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差沿着边缘的长度小于约6μm。
-
公开(公告)号：US07287318B2
公开(公告)日：2007-10-30
申请号：US10703408
申请日：2003-11-07
IPC分类号： H01R43/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , Y10T29/49 , Y10T29/49002 , Y10T29/49007 , Y10T29/49117
摘要： A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
摘要翻译： 提供了一种生物传感器，其包括具有预定反应区的板元件和邻近反应区定位的凹部。 生物传感器还包括位于反应区上的试剂。 在优选的实施方案中，凹部限定反应区的至少一部分。
-
公开(公告)号：US06911621B2
公开(公告)日：2005-06-28
申请号：US10338498
申请日：2003-01-08
IPC分类号： G01N33/483 , B81B1/00 , G01N27/327 , G01N27/49 , G01N33/543 , B23K26/36
CPC分类号： G01N33/5438 , G01N33/54366 , Y10T29/49002
摘要： A method of forming a biosensor is provided. The method includes providing a substrate and a cover including first and second surfaces, positioning a reagent on the substrate, carving a channel by laser ablation in the first surface, and coupling the first surface of the cover to the second surface. The channel includes a first portion having a first height and a second portion having a second height that is less than the first height.
摘要翻译： 提供了形成生物传感器的方法。 该方法包括提供基底和包括第一表面和第二表面的盖，将试剂放置在基底上，通过在第一表面中的激光烧蚀来雕刻通道，以及将盖的第一表面连接到第二表面。 通道包括具有第一高度的第一部分和具有小于第一高度的第二高度的第二部分。
-
公开(公告)号：US06485471B1
公开(公告)日：2002-11-26
申请号：US09518817
申请日：2000-03-03
IPC分类号： A61M5178
CPC分类号： A61M5/1452 , A61M5/148 , A61M5/282 , A61M2005/14506 , A61M2005/14533
摘要： A fluid-delivery apparatus for delivering a medicament to a patient is provided in accordance with the present invention. The apparatus includes a housing defining a passageway, a bellowed ampoule positioned to lie in the passageway of the housing, and a piston. The bellowed ampoule includes a body with first and second ends and is formed to define a cavity configured to contain the medicament. The piston presses the second end of the ampoule toward the first end to dispense the medicament from the cavity. In addition, the fluid-delivery apparatus includes a visible non-linear scale that represents the relationship between a volume of medicament delivered from the first end of the ampoule and a distance that the piston has traveled in the housing toward the first end.
摘要翻译： 根据本发明提供了一种用于将药物递送到患者的流体输送装置。 该装置包括限定通道的壳体，定位成位于壳体的通道中的波纹安瓿和活塞。 波纹安瓿包括具有第一和第二端的主体并且形成为限定被配置为容纳药物的腔。 活塞将安瓿的第二端朝向第一端压入以从药腔分配药剂。 此外，流体输送装置包括可见的非线性标度，其表示从安瓿的第一端输送的药物的体积与活塞在壳体中朝向第一端行进的距离之间的关系。
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.022 秒)
