公开(公告)号：US20030096131A1

公开(公告)日：2003-05-22

申请号：US09880476

申请日：2001-06-12

Applicant: Biocoat Incorporated

Inventor： Ellington M. Beavers ,  William James Work

IPC: B32B027/08 ,  B32B027/30

CPC classification number: A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/08 ,  Y10T428/31536 ,  Y10T428/31855 ,  Y10T428/3188 ,  Y10T428/31884 ,  Y10T428/31891 ,  Y10T428/31928 ,  Y10T428/31935

Abstract: Biocompatible, lubricious, highly durable coatings for medical devices are formed from a highly adherent base coat and a hydrophilic top-coat which is chemically grafted to the base coat. The base coat includes an aqueous acrylic emulsion polymer, having one or more monomers having alkyl groups of varying number. The monomers are combined such that the nullEquivalent Alkyl Numbernull, essentially a weighted average number of carbon atoms, for the resulting polymer or copolymer, is in a range of about 3.5-4.5. The coating is prepared without using any organic solvents, and thus the final product contains no residue of such solvents. The coated products display an unmatched combination of adhesion, abrasion resistance, water resistance, biocompatibility, and lubricity.

Abstract translation: 用于医疗器械的生物相容性，润滑性，高度耐用的涂层由高度粘附的底涂层和化学接枝到底涂层上的亲水性顶涂层形成。 底涂层包括具有一个或多个具有不同数目的烷基的单体的含水丙烯酸乳液聚合物。 将单体组合使得所得聚合物或共聚物的“等当量烷基数”基本上为加权平均碳原子数在约3.5-4.5的范围内。 制备涂层而不使用任何有机溶剂，因此最终产品不含有这些溶剂的残留物。 涂层产品显示出无与伦比的粘合性，耐磨性，耐水性，生物相容性和润滑性的组合。

公开(公告)号：US20020068093A1

公开(公告)日：2002-06-06

申请号：US09940849

申请日：2001-08-29

Applicant: Biocoat Incorporated

Inventor： Jeffrey A. Trogolo ,  James B. Johnston ,  Elizabeth A. Pastecki ,  Elizabeth Pervin ,  Amy Stahl ,  Mark Hyman

IPC: A61M025/00 ,  A61M005/32 ,  A61K033/38 ,  A61K031/728

CPC classification number: C08K3/34 ,  A61L27/306 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/10 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/236 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/608 ,  A61L2420/08 ,  A61M2025/0056 ,  C08K9/02 ,  C08L5/08 ,  C08L5/00

Abstract: An article including a surface having a coating thereon, in which the coating includes a base coat, firmly adhered to the surface, and a hydrophilic, biocompatible top-coat. An antibiotic ceramic component is dispersed in one or both of the base coat and top-coat. Preferably, the ceramic component is dispersed in the base coat. In a preferred embodiment, the ceramic component is a zeolite with silver ions exchanged onto internal acidic sites of the zeolite, and the top-coat includes a polysaccharide, such as hyaluronan. The zeolite is highly effective in imparting anti-microbial character to the coating.

Abstract translation: 一种包括其上具有涂层的表面的制品，其中所述涂层包括牢固粘合到所述表面上的底涂层和亲水的生物相容的顶涂层。 抗生素陶瓷组分分散在底涂层和顶涂层中的一种或两种中。 优选地，陶瓷组分分散在底涂层中。 在优选的实施方案中，陶瓷组分是具有银离子交换到沸石的内部酸性位点上的沸石，并且顶涂层包括多糖，如透明质酸。 沸石对涂层赋予抗微生物特性非常有效。

公开(公告)号：US12214146B2

公开(公告)日：2025-02-04

申请号：US17118143

申请日：2020-12-10

Applicant: Biocoat, Incorporated

Inventor： William James Work ,  Raymond Joseph Gould ,  Dhruv Patel ,  Robert W Hergenrother

IPC: A61M25/10 ,  A61K31/145 ,  A61K31/155 ,  A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/437 ,  A61K31/4409 ,  A61K31/473 ,  A61K31/502 ,  A61K31/505 ,  A61K31/506 ,  A61K31/52 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/655 ,  A61K31/7008 ,  A61K31/7048 ,  A61K31/7076 ,  A61K31/708 ,  A61L29/08 ,  A61L29/16 ,  B05D5/00 ,  B05D7/00

Abstract: The present invention is an implantable medical device comprising (i) a base coat layer having an inner and outer surface, the inner surface of the base coat layer contacting the implantable medical device; (ii) a top-coat layer of a hydrophilic polymer chemically crosslinked and covalently bonded to the outer surface of the base coat layer, the hydrophilic polymer comprising an anionic polyelectrolyte; and (iii) an amount of a hydrophilic cationic drug agent added to the top-coat layer sufficient to provide an effective dosage of the drug agent for delivery to a patient, whereby the hydrophilic cationic drug agent is initially adsorbed into the anionic polyelectrolyte of the top-coat layer and the hydrophilic cationic drug agent having a release rate after the medical device is implanted within a patient's body.

公开(公告)号：US12037560B2

公开(公告)日：2024-07-16

申请号：US17075965

申请日：2020-10-21

Applicant: Biocoat, Incorporated

Inventor： Tyler Richard Long ,  Casmir S. Ilenda

IPC: C10M107/42 ,  A61L2/08 ,  A61L2/20 ,  A61L101/44 ,  C10N40/00 ,  C10N50/08

CPC classification number: C10M107/42 ,  A61L2/081 ,  A61L2/087 ,  A61L2/206 ,  A61L2101/44 ,  A61L2202/21 ,  C10M2217/0245 ,  C10N2040/50 ,  C10N2050/08

Abstract: The invention concerns coating compositions for medical devices or medical implants comprising a polymer which is soluble in water or water-alcohol solutions, the polymer made from monomers comprising: (a) at least one monomer that is a photo radical generator, and (b) at least one monomer comprising one or both of (i) ethylenic monomers comprising at least one acidic group and (ii) one or more of acrylates or acrylamides; wherein the molar ratio of one or both of (i) ethylenic monomers comprising at least one acidic group and (ii) one or more of acrylates or acrylamides to photo radical generator group is 20:1 to 500:1.

公开(公告)号：US12064566B1

公开(公告)日：2024-08-20

申请号：US18337560

申请日：2023-06-20

Applicant: Biocoat, Incorporated

Inventor： Spencer Thomas Bass ,  Zichun Jacqueline Lu-Wright

IPC: B05C3/02 ,  A61L29/08 ,  A61L29/10 ,  A61M25/00 ,  B05C7/00 ,  B05C7/04 ,  B05D1/18 ,  B05D7/22

CPC classification number: A61M25/0045 ,  A61L29/085 ,  A61L29/106 ,  B05C3/02 ,  B05C7/00 ,  B05C7/04 ,  B05D1/18 ,  B05D7/22 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08

Abstract: A method for coating the lumen of a tube comprises the steps of inserting the distal opening of a tube into a first coating solution, drawing the first coating solution into the lumen of the tube, draining the first coating solution from the lumen leaving a film of the first coating solution on the lumen of the tube, and curing the first coating solution. This leaves a first coating on the lumen of the tube. A coating apparatus comprises a pallet, and one or more dip funnels. The pallet comprises a manifold and is configured to fluidically connect the manifold to one or more tubes. The one or more dip funnels are configured to hold a coating solution and are located below the pallet so that when the pallet is moved vertically, the one or more tubes are inserted into the dip funnels.

公开(公告)号：US11578286B2

公开(公告)日：2023-02-14

申请号：US17663942

申请日：2022-05-18

Applicant: Biocoat, Incorporated

Inventor： Tyler Richard Long ,  Casmir S Ilenda

IPC: C10M107/28 ,  C08F220/18 ,  C08F220/14 ,  C10M107/42 ,  C10M107/36 ,  A61L29/14 ,  C10N40/00 ,  C10N50/00 ,  A61L29/08 ,  A61L31/10

Abstract: The invention concerns coating composition comprising hydrophobic polymer for use as a photoreactive basecoat for a medical device or implant comprising a polymer made from monomers comprising: (a) 1 to 12 mol % of at least one photoactive monomer that is a hydrogen atom abstracter and (b) 99 to 88 mol % of one or more of acrylamides, methacrylamides, acrylates, methacrylates, and N-vinylpyrrolidone; wherein the polymer has a glass transition temperature (Tg) of less than 40° C.