公开(公告)号：US12214146B2

公开(公告)日：2025-02-04

申请号：US17118143

申请日：2020-12-10

Applicant: Biocoat, Incorporated

Inventor： William James Work ,  Raymond Joseph Gould ,  Dhruv Patel ,  Robert W Hergenrother

IPC: A61M25/10 ,  A61K31/145 ,  A61K31/155 ,  A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/437 ,  A61K31/4409 ,  A61K31/473 ,  A61K31/502 ,  A61K31/505 ,  A61K31/506 ,  A61K31/52 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/655 ,  A61K31/7008 ,  A61K31/7048 ,  A61K31/7076 ,  A61K31/708 ,  A61L29/08 ,  A61L29/16 ,  B05D5/00 ,  B05D7/00

Abstract: The present invention is an implantable medical device comprising (i) a base coat layer having an inner and outer surface, the inner surface of the base coat layer contacting the implantable medical device; (ii) a top-coat layer of a hydrophilic polymer chemically crosslinked and covalently bonded to the outer surface of the base coat layer, the hydrophilic polymer comprising an anionic polyelectrolyte; and (iii) an amount of a hydrophilic cationic drug agent added to the top-coat layer sufficient to provide an effective dosage of the drug agent for delivery to a patient, whereby the hydrophilic cationic drug agent is initially adsorbed into the anionic polyelectrolyte of the top-coat layer and the hydrophilic cationic drug agent having a release rate after the medical device is implanted within a patient's body.