公开(公告)号：US06248056B1

公开(公告)日：2001-06-19

申请号：US09269119

申请日：1999-03-19

Applicant: Bertil Persson

Inventor： Bertil Persson

IPC: A61N500

CPC classification number: A61N1/326 ,  A61N5/10

Abstract: An apparatus (40) according to the invention includes a radiation emitter (34) for ionizing radiation and a high voltage generator (1) for generating brief voltage pulses for voltage application of electrodes (6, 15, 16, 24) included in the apparatus. The electrodes are designed to be secured at or introduced into tissue in a restricted region of a human or an animal and to form between them an electric field in the tissue. The radiation emitter (34) is provided to emit ionizing radiation to a tumor in the tissue in that region which is to be treated, while the electrodes (6, 15, 16, 24) are disposed to be placed in or at the tumor in order that the electric field pass through the tumor.

Abstract translation: 根据本发明的装置（40）包括用于电离辐射的辐射发射器（34）和用于产生用于电压施加包括在装置中的电极（6,15,16,24）的短暂电压脉冲的高压发生器（1） 。 电极被设计成固定在人或动物的受限区域中的组织中或在其中引入组织中并且在它们之间形成组织中的电场。 辐射发射器（34）被设置为向待处理的区域中的组织中的肿瘤发射电离辐射，同时将电极（6,15,16,24）放置在放置在肿瘤中或其中的肿瘤中 命令电场通过肿瘤。

公开(公告)号：US4692084A

公开(公告)日：1987-09-08

申请号：US802052

申请日：1985-11-25

Applicant: Bertil Persson

Inventor： Bertil Persson

IPC: B62B3/06 ,  B65G7/08 ,  B66C23/82 ,  B66F7/08 ,  B65F3/00

CPC classification number: B62B3/0625 ,  B65G7/08 ,  B66C23/82 ,  B66F7/0625 ,  B66F7/0633 ,  B66F7/0691 ,  B66F7/08 ,  B62B2202/02 ,  Y10S414/125

Abstract: The present invention relates to a lifting apparatus, especially a barrel tilter, which is preferably raisable and movable by means of a low lift truck (4). To eliminate the need for power units in each of the lifting apparatuses, the lifting apparatus (1, 37, 45, 50) comprises a base member (2) onto which a low lift truck (4), preferably a lift truck by means of which the lifting apparatus is raisable and movable, can be driven to weight the base member (2) from above, and a lifting unit (3) movably connected to the base member (2) is so arranged in relation to the base member (2) that the parts of the truck (4) which are to perform lifting are positioned beneath the lifting unit (3) when the truck (4) has been driven onto the base member (2), whereby the lifting unit (3) can be operated by the parts of the truck (4) adapted to perform lifting to impart lifting movements to the lifting unit (3) while the base member (2) is weighted by the truck (4).

Abstract translation: 本发明涉及一种提升设备，特别是一种桶式倾斜器，其优选地可升高并借助于低升降叉车（4）可移动。 为了消除对每个提升装置中的动力单元的需要，提升装置（1，37,45,50）包括基座构件（2），在该基座构件（2）上安装有小型起重车（4），优选地是通过 升降装置可升高并可移动的装置可以被驱动以从上方对基部构件（2）进行加重，并且可移动地连接到基部构件（2）的提升单元（3）相对于基座构件（2） ），当卡车（4）被驱动到基部构件（2）上时，要提升的卡车（4）的部件位于提升单元（3）的下方，由此提升单元（3）可以 由叉车（4）的部件操作，其适于执行提升以在提升单元（3）提升运动的同时，同时由卡车（4）对基座构件（2）进行加权。

公开(公告)号：US4238865A

公开(公告)日：1980-12-16

申请号：US27119

申请日：1979-04-04

Applicant: Bertil Ingemann ,  Bertil Persson

Inventor： Bertil Ingemann ,  Bertil Persson

IPC: A47G25/00 ,  A43D5/00 ,  A44B21/00 ,  A47F7/08

CPC classification number: A47G25/005 ,  Y10T24/44701 ,  Y10T24/44872

Abstract: A boot support device including a pair of shanks which engage each other intermediate their ends but closest to the upper end of the device. The inter-engagement of the shanks effects a rocking movement between the shanks to cause the lower ends of the shanks to move apart to facilitate insertion into the legs of boots. The divergence of the lower ends is effected by causing sections of the shanks near the upper ends to be squeezed together. A predetermined divergence may be effected by movement into a certain position of a hollow slider which is displaceable along the shanks. Divergence of the lower ends of the shanks may also be effected by manually squeezing together opposed sides of a loop-shaped connection extending between the shanks at the upper end.

Abstract translation: 靴子支撑装置，包括一对杆，它们在其端部之间彼此接合，但最靠近装置的上端。 柄部的相互接合影响柄之间的摇摆运动，从而导致柄的下端分开以便于插入靴子的腿部。 下端的发散通过使上端附近的柄部分被挤压在一起而实现。 可以通过移动到沿着柄部移位的中空滑块的特定位置来实现预定的发散。 柄的下端的发散也可以通过手动挤压在上端的柄之间延伸的环形连接的相对侧而实现。

公开(公告)号：US07306940B2

公开(公告)日：2007-12-11

申请号：US10274738

申请日：2002-10-21

Applicant: Damijan Miklavcic ,  Lluis Mir ,  Eberhard Neumann ,  Bertil Persson

Inventor： Damijan Miklavcic ,  Lluis Mir ,  Eberhard Neumann ,  Bertil Persson

IPC: C12M3/00

CPC classification number: A61N1/327 ,  A61N1/0412 ,  C12M35/02

Abstract: An electroporation device having a signal generating circuit (3) connectable at the output to electrodes (5) fittable to a substrate (35) having cells. The electrodes (5) produce an electric field which induces permeabilization of the cell membranes to facilitate introduction of substances into the cells. The amplitude of the signal (12) applied to the electrodes is closed-loop controlled on the basis of the impedance (Z(ω)) of the substrate, so as to regulate the amplitude of the signal following a reduction in impedance caused by permeabilization of the cell membranes.

Abstract translation: 一种电穿孔装置，其具有可在输出端连接到电极（5）的信号发生电路（3），电极（5）可装配到具有电池的基板（35）。 电极（5）产生电场，其诱导细胞膜的透化以促进物质进入细胞。 施加到电极的信号（12）的振幅基于衬底的阻抗（Z（ω））进行闭环控制，以便调节由透化引起的阻抗减小之后的信号的幅度 的细胞膜。

公开(公告)号：US4302173A

公开(公告)日：1981-11-24

申请号：US15971

申请日：1979-02-28

Applicant: Bertil Persson

Inventor： Bertil Persson

IPC: A22C7/00 ,  A21C5/00

CPC classification number: A22C7/00

Abstract: A machine for moulding mouldable products, preferably foodstuff masses. A piston is slidable in a piston passage of a housing and a moulding tool defining a moulding cavity is slidable in a moulding tool passage of the housing. The piston and moulding tool are coupled to a common rotary drive disc for reciprocation such that when the moulding tool is in a first position, the piston pumps the mouldable product into the moulding cavity, compacting the product to a desired consistency, and when the moulding tool is in a second position, the mouldable product compacted in the moulding cavity is discharged from the machine.

Abstract translation: 用于成型可成型产品的机器，优选食品块。 活塞可在壳体的活塞通道中滑动，并且限定模制腔的模制工具可在壳体的模制工具通道中滑动。 活塞和模制工具联接到共同的旋转驱动盘以便往复运动，使得当模具处于第一位置时，活塞将可模制产品泵送到模腔中，将产品压实成所需的稠度，并且当成型 工具处于第二位置，压缩在模腔中的可模制产品从机器排出。

公开(公告)号：US20080289299A1

公开(公告)日：2008-11-27

申请号：US12094678

申请日：2006-11-09

Applicant: Carl-Erik Mansson ,  Hans Hellstrom ,  Bertil Persson ,  Monica Jartelius

Inventor： Carl-Erik Mansson ,  Hans Hellstrom ,  Bertil Persson ,  Monica Jartelius

IPC: B65B31/02

CPC classification number: B65B31/00 ,  B65B31/041 ,  B65B55/10

Abstract: A method of reducing the proportion of oxygen in an at least partly formed package before product is filled into the package in a filling station in a filling machine, where the package comprises a tube-shaped blank of packaging material, the blank being closed in a first end and open in a second end. The method involves, during transport of the package to the filling station from an immediately preceding station in the filling machine, passing the package beneath a supply means for inert gas, and when the package passes the supply means generating a gas pulse in a direction down into the package. An apparatus is provided for reducing the method into practice.

Abstract translation: 在填充机中的填充站中将产品填充到包装中之前，将至少部分形成的包装中的氧气的比例减少的方法，其中包装包括管状的包装材料坯料，坯料封闭在 第一端并在第二端打开。 该方法包括在将包装从填充机器中的紧接在前的站运送到加​​料站期间，将包装件在惰性气体的供给装置下方通过，并且当包装件通过供给装置沿着向下的方向产生气体脉冲时 进入包装。 提供了一种用于将方法减少到实践中的装置。

公开(公告)号：US20110300142A1

公开(公告)日：2011-12-08

申请号：US12601021

申请日：2008-05-26

Applicant: Leif G. Salford ,  Bertil Persson ,  Hans Olov Sjögren ,  Bengt Widegren

Inventor： Leif G. Salford ,  Bertil Persson ,  Hans Olov Sjögren ,  Bengt Widegren

IPC: A61K39/395 ,  A61K31/7068 ,  A61K38/16 ,  C07H19/073 ,  C07H19/10 ,  A61P43/00 ,  A61P7/06 ,  A61P17/14 ,  A61P37/08 ,  A61P37/06 ,  A61P7/00 ,  A61P29/00 ,  A61P1/00 ,  A61P3/10 ,  A61P13/12 ,  A61P1/16 ,  A61P27/02 ,  A61P25/00 ,  A61P25/20 ,  A61P1/18 ,  A61P17/06 ,  A61P17/00 ,  A61P9/00 ,  A61P9/10 ,  A61P25/16 ,  C07H19/067

CPC classification number: C12N5/0636 ,  A61K31/495 ,  A61K31/513 ,  A61K31/706 ,  A61K31/7068 ,  A61K39/0008 ,  A61K39/001 ,  A61K2039/5154 ,  A61K2039/577 ,  C12N2501/22 ,  C12N2501/73 ,  C12N2501/999 ,  Y02A50/414

Abstract: The invention relates to the use of 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one derivative or mimetic or an analogue, derivatives, metabolites, variants or salts thereof for the manufacturing of a medicament to increase the amount of Indoleamine 2,3-dioxygenase (IDO) production in order to induce immunological tolerance as well as a method of treating a mammal in need thereof.

Abstract translation: 本发明涉及1 - （＆bgr。-D-呋喃核糖基）-1,2-二氢嘧啶-2-酮衍生物或其模拟物或类似物，衍生物，代谢物，变体或盐在制备药物中的用途，以增加 为了诱导免疫耐受性，吲哚胺2,3-双加氧酶（IDO）生产的量以及治疗有需要的哺乳动物的方法。

公开(公告)号：US20070118069A1

公开(公告)日：2007-05-24

申请号：US11656549

申请日：2007-01-22

Applicant: Bertil Persson ,  Bernt Bohmer ,  Bo Thorvinger

Inventor： Bertil Persson ,  Bernt Bohmer ,  Bo Thorvinger

IPC: A61N1/30

CPC classification number: A61N1/325 ,  A61B5/05 ,  A61N1/0412 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0502 ,  A61N1/08 ,  A61N1/323 ,  A61N1/327

Abstract: An apparatus for treating tumors utilizing an electric field in which a voltage generator generates brief voltage pulses applied to electrodes connected to a measurement unit. The electrodes are secured at a restricted region of a human or an animal and form electric fields in the tissue between the electrodes. The measurement unit determines the impedance between the electrodes which is substantially determined by the electric properties of the tissue between the electrodes. A registration and calculator device forms a control unit which, based on the impedance determined by the measurement unit, controls the output voltage of the voltage generator such that the electric field which is formed in the tissue has a constant predetermined value and realizes a peroration of cell membranes in the tissue which permits passage of treatment substances fed to the patient.

Abstract translation: 一种利用电场治疗肿瘤的装置，其中电压发生器产生施加到连接到测量单元的电极的短暂的电压脉冲。 电极固定在人或动物的受限区域，并在电极之间的组织中形成电场。 测量单元确定电极之间的阻抗，其基本上由电极之间的组织的电特性确定。 配准和计算器装置形成控制单元，其基于由测量单元确定的阻抗来控制电压发生器的输出电压，使得在组织中形成的电场具有恒定的预定值，并且实现 组织中的细胞膜允许供给给患者的治疗物质通过。

公开(公告)号：US20060015147A1

公开(公告)日：2006-01-19

申请号：US11204258

申请日：2005-08-15

Applicant: Bertil Persson ,  Bernt Bohmer ,  Bo Thorvinger

Inventor： Bertil Persson ,  Bernt Bohmer ,  Bo Thorvinger

IPC: A61N1/39 ,  A61N1/18

CPC classification number: A61N1/325 ,  A61B5/05 ,  A61N1/0412 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0502 ,  A61N1/08 ,  A61N1/323 ,  A61N1/327

Abstract: An apparatus (60) according to the present invention includes a voltage generator (1) for generating brief voltage pulses for the impression of voltage on electrodes (6, 15, 16, 24) included in the apparatus, and a measurement unit (50) which is coupled to the electrodes. These are designed to be secured at or inserted in tissue in a restricted region of a human or an animal in order therebetween to form electric fields in the tissue. The measurement unit (50) is disposed to determine the impedance between the electrodes which is substantially determined by the electric properties of the tissue which is located between the electrodes. A registration and calculator device (10) forms a control unit which, based on the impedance determined by the measurement unit, controls the output voltage of the voltage generator such that the electric field which is formed in the tissue always has a predetermined value. The treatment with the electric field realizes a perforation of cell membranes in the tissue which thereby permits the passage of substances fed to the body (e.g. cytostatic or genetic material).

Abstract translation: 根据本发明的装置（60）包括：电压发生器（1），用于产生用于在装置中包括的电极（6,15,16,24）上的电压印象的短暂电压脉冲;以及测量单元（50） 其耦合到电极。 这些被设计成固定在人或动物的限制区域中的组织中或插入组织中以在它们之间形成电场。 设置测量单元（50）以确定电极之间的阻抗，其基本上由位于电极之间的组织的电特性决定。 配准和计算器装置（10）形成控制单元，其基于由测量单元确定的阻抗来控制电压发生器的输出电压，使得组织中形成的电场总是具有预定值。 电场治疗实现了组织中细胞膜的穿孔，从而允许进入身体的物质（例如细胞抑制或遗传物质）通过。

公开(公告)号：US06237278B1

公开(公告)日：2001-05-29

申请号：US09242387

申请日：1999-04-16

Applicant: Bertil Persson ,  Pär Henriksson ,  Tomas Nybrant ,  Berit Mattsson

Inventor： Bertil Persson ,  Pär Henriksson ,  Tomas Nybrant ,  Berit Mattsson

IPC: A01M2104

CPC classification number: A01M21/046

Abstract: Weed seeds are controlled by high voltage pulses with short duration which electropermeabilize the cell membranes of weed seeds in the ground. The device is selective and damages only germinating weed seeds and plants early in their life cycle. The required amount of energy is small; with rectangular pulses the optimal field strength is between 100-300 kV/m with a duration of (10-100 microseconds). A transformer placed on a sowing machine transforms electrical energy to high voltage pulses. The energy may be taken from the pulling tractor via a transmission or from an integrated power source. The high voltage pulses are applied to electrically conducting via applicators to two or more fixedly spaced plates to the soil around newly sown seeds.

Abstract translation: 杂草种子由持续时间短的高电压脉冲控制，电渗透地面上的杂草种子的细胞膜。 该设备是选择性的，并且在其生命周期的早期仅损害发芽的杂草种子和植物。 所需能量很小; 使用矩形脉冲，最佳场强在100-300kV / m之间，持续时间（10-100微秒）。 放置在播种机上的变压器将电能转换成高压脉冲。 能量可以通过传动装置或从集成的动力源从牵引车上取出。 将高电压脉冲施加到导电通孔施加器到两个或更多个固定间隔的板到新播种的种子周围的土壤。