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    Sustained release drug carrier, and method of manufacturing sustained release drug carrier
    1.
    发明授权
    Sustained release drug carrier, and method of manufacturing sustained release drug carrier 失效
    持续释放药物载体，以及缓释药物载体的制备方法

    公开(公告)号：US06719989B1

    公开(公告)日：2004-04-13

    申请号：US09658021

    申请日：2000-09-08

    申请人： Asako Matsushima ,  Masanori Nakasu ,  Makoto Otsuka

    发明人： Asako Matsushima ,  Masanori Nakasu ,  Makoto Otsuka

    IPC分类号： A61F1300

    CPC分类号： A61K9/0024 ,  A61K9/2009 ,  A61L31/026 ,  A61L31/16 ,  A61L2300/602

    摘要： A sustained release drug carrier comprises a ceramic composite which is formed by bonding a plurality of ceramic bodies together, and drugs impregnated into the ceramic composite. A method of manufacturing the sustained release drug carrier comprises the steps of: (i) preparing ceramic bodies to be bonded together, each of the ceramic bodies having a bonding surface; (ii) preparing a slurry in which primary particles of a bonding ceramics are dispersed; (iii) applying the slurry to the bonding surface of at least one of the ceramic bodies to be bonded; (iv) sintering the ceramic bodies between which the slurry has been interposed to bond them together, to obtain a ceramic composite; and (v) impregnating a drug into the obtained ceramic composite. According to the structure and method described above, it is possible to provide a sustained release drug carrier whose drug release properties can be controlled and which is capable of exhibiting better drug release action suitable for the application sites, type of drugs to be carried, and the like.

    摘要翻译： 缓释药物载体包括通过将多个陶瓷体粘合在一起形成的陶瓷复合材料和浸渍到陶瓷复合材料中的药物。 制备缓释药物载体的方法包括以下步骤：（i）制备要结合在一起的陶瓷体，每个陶瓷体具有接合表面; （ii）制备其中分散结合陶瓷的一次颗粒的浆料; （iii）将浆料施加到待粘合的至少一个陶瓷体的接合面上; （iv）烧结已经插入浆料的陶瓷体将它们结合在一起，得到陶瓷复合体; 和（v）将药物浸渍到所获得的陶瓷复合材料中。 根据上述结构和方法，可以提供一种缓释药物载体，其药物释放性能可以被控制，并且能够表现出适合于施用部位的更好的药物释放作用，待携带的药物的类型，以及 类似。

    Method for manufacturing a sintered compact for use as a cell culture base
    2.
    发明授权
    Method for manufacturing a sintered compact for use as a cell culture base 失效
    制造用作细胞培养基的烧结体的方法

    公开(公告)号：US07563608B2

    公开(公告)日：2009-07-21

    申请号：US10638338

    申请日：2003-08-12

    申请人： Tsuyoshi Ishikawa ,  Kazuyoshi Yamaguchi ,  Asako Matsushima

    发明人： Tsuyoshi Ishikawa ,  Kazuyoshi Yamaguchi ,  Asako Matsushima

    IPC分类号： C12N11/14 ,  C12N5/00 ,  C04B35/00

    CPC分类号： C04B35/447 ,  C04B35/64 ,  C04B2235/3208 ,  C04B2235/3212 ,  C04B2235/44 ,  C04B2235/447 ,  C04B2235/5436 ,  C04B2235/604 ,  C04B2235/6585 ,  C04B2235/661 ,  C04B2235/77 ,  C04B2235/80 ,  C04B2235/963 ,  C04B2235/9653 ,  C12N5/0068 ,  C12N2533/18

    摘要： A method for manufacturing a sintered compact having high density, and a sintered compact manufactured by the manufacturing method are provided. The manufacturing method comprises the steps of preparing hydroxyapatite powder, molding a green compact, shaping the green compact, and sintering the green compact. Further, a method for manufacturing a sintered compact having high light permeability, and a sintered compact manufactured by the manufacturing method are provided. The manufacturing method comprises the steps of preparing hydroxyapatite powder, molding a green compact, shaping the green compact, primary sintering, and secondary sintering. Furthermore, a cell culture base formed from the sintered compact described above is provided, by which affinity of various cells with bone can be properly determined. Moreover, a cell culture base by which affinity of various cells with bone can be properly determined is provided. The cell culture base is mainly composed of a calcium phosphate based compound, and is highly compacted.

    摘要翻译： 提供了一种制造具有高密度的烧结体的方法和通过该制造方法制造的烧结体。 制造方法包括制备羟基磷灰石粉末，成型生坯，成形生坯，烧结生坯的步骤。 此外，提供了一种制造具有高透光性的烧结体的方法和通过该制造方法制造的烧结体。 该制造方法包括以下步骤：制备羟基磷灰石粉末，成型生坯，成型生坯，一次烧结和二次烧结。 此外，提供由上述烧结体形成的细胞培养基，可以适当地确定各种细胞与骨的亲和力。 另外，提供了可以适当确定各种细胞与骨的亲和力的细胞培养基。 细胞培养基主要由磷酸钙基化合物组成，高度压实。

    Prosthetic filler for a living body and method of manufacturing the prosthetic filler
    3.
    发明授权
    Prosthetic filler for a living body and method of manufacturing the prosthetic filler 失效
    用于生物体的假体填料和制造假体填料的方法

    公开(公告)号：US06903146B2

    公开(公告)日：2005-06-07

    申请号：US10134588

    申请日：2002-04-30

    申请人： Asako Matsushima ,  Masanori Nakasu ,  Takahiro Fukuhara

    发明人： Asako Matsushima ,  Masanori Nakasu ,  Takahiro Fukuhara

    IPC分类号： A61L27/00 ,  A61K6/033 ,  A61L27/46 ,  A61L27/56 ,  A61F2/02 ,  A61K9/14 ,  C08J9/32 ,  C08K3/32

    CPC分类号： A61L27/46 ,  A61L27/56

    摘要： A prosthetic filler for a living body having excellent storage properties and handlability is disclosed. The prosthetic filler includes calcium phosphate granules and porous small chips made of an organic material for binding these calcium phosphate granules to each other. The prosthetic filler is made by mixing the calcium phosphate granules and the small chips of the organic material. When the prosthetic filler is used for a living body, it is added with water, and then they are kneaded to become a paste state. Thus obtained paste state prosthetic filler is injected into a bone defect site or the like to restore it.

    摘要翻译： 公开了一种具有优异的储存性能和可处理性的生物体的假体填料。 假体填料包括磷酸钙颗粒和由用于将这些磷酸钙颗粒彼此结合的有机材料制成的多孔小芯片。 通过混合磷酸钙颗粒和有机材料的小芯片来制备假体填料。 当假体填料用于生物体时，加入水，然后将其捏合成糊状。 将这样得到的膏状补充填料注入骨缺损部位等，使其恢复。