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1.发明授权Systems and methods for replacing signal artifacts in a glucose sensor data stream 有权用于替换葡萄糖传感器数据流中的信号伪影的系统和方法公开(公告)号：US09149219B2
公开(公告)日：2015-10-06
申请号：US13024076
申请日：2011-02-09
申请人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
发明人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
IPC分类号： A61B5/05 , A61B5/00 , A61B5/1486 , A61B5/145
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
摘要翻译： 用于最小化或消除由于非葡萄糖速率限制现象（如缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。 系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。 该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。 该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号 估计算法。
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公开(公告)号：US08882741B2
公开(公告)日：2014-11-11
申请号：US13460219
申请日：2012-04-30
申请人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
发明人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
摘要翻译： 提供了用于集成包括接收器，药物输送装置和任选的单点葡萄糖监测器的连续葡萄糖传感器的系统和方法。 手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。 设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间 例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。 设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。
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公开(公告)号：US08821400B2
公开(公告)日：2014-09-02
申请号：US13023776
申请日：2011-02-09
申请人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
发明人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
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公开(公告)号：US08394021B2
公开(公告)日：2013-03-12
申请号：US11865660
申请日：2007-10-01
申请人： Paul V. Goode , James H. Brauker , Apurv U. Kamath
发明人： Paul V. Goode , James H. Brauker , Apurv U. Kamath
CPC分类号： A61B5/1468 , A61B5/0031 , A61B5/1433 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/4839 , A61B5/743 , A61B2560/0223 , A61B2560/04 , A61B2562/085 , G01N33/48707 , G06F19/00 , Y02A90/22 , Y02A90/26
摘要： Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.
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5.发明授权System and methods for replacing signal artifacts in a glucose sensor data stream 有权用于替换葡萄糖传感器数据流中的信号伪像的系统和方法公开(公告)号：US08346338B2
公开(公告)日：2013-01-01
申请号：US13014910
申请日：2011-01-27
申请人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
发明人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
摘要翻译： 用于最小化或消除由于非葡萄糖速率限制现象（如缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。 系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。 该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。 该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号 估计算法。
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6.发明授权Systems and methods for replacing signal artifacts in a glucose sensor data stream 有权用于替换葡萄糖传感器数据流中的信号伪影的系统和方法公开(公告)号：US08292810B2
公开(公告)日：2012-10-23
申请号：US13015245
申请日：2011-01-27
申请人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
发明人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
IPC分类号： A61B5/00
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
摘要翻译： 用于最小化或消除由于非葡萄糖速率限制现象（如缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。 系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。 该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。 该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号 估计算法。
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公开(公告)号：US08285354B2
公开(公告)日：2012-10-09
申请号：US12730077
申请日：2010-03-23
IPC分类号： A61B5/05
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B2560/0223 , G06F19/00
摘要： Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.
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公开(公告)号：US08275437B2
公开(公告)日：2012-09-25
申请号：US11690752
申请日：2007-03-23
申请人： James H. Brauker , Apurv U. Kamath , Paul V. Goode , Mark Brister
发明人： James H. Brauker , Apurv U. Kamath , Paul V. Goode , Mark Brister
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0031 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6833 , A61B5/6848 , A61B5/743 , A61B2560/0223 , A61B2560/0252 , A61B2560/04 , A61B2562/085
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
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公开(公告)号：US20120238852A1
公开(公告)日：2012-09-20
申请号：US13460365
申请日：2012-04-30
申请人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
发明人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
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公开(公告)号：US20120190953A1
公开(公告)日：2012-07-26
申请号：US13436534
申请日：2012-03-30
申请人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
发明人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
IPC分类号： A61B5/145
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/3468 , G16H20/17 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
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