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    Hydroxyphenyl cross-linked macromolecular network and applications thereof
    3.
    发明申请
    Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
    羟基苯基交联大分子网络及其应用

    公开(公告)号：US20050265959A1

    公开(公告)日：2005-12-01

    申请号：US11198803

    申请日：2005-08-05

    申请人： Anthony Calabro ,  Richard Gross ,  Aniq Darr

    发明人： Anthony Calabro ,  Richard Gross ,  Aniq Darr

    IPC分类号： A61K31/74 ,  A61K31/765 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  A61L27/52 ,  C08F261/02 ,  C08G63/48 ,  C08G63/81 ,  C08G63/91 ,  C08G73/02 ,  C08L71/00 ,  C12Q20060101

    CPC分类号： A61L27/52 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  C08G63/81 ,  C08G73/02 ,  C08J3/075 ,  C08L101/14

    摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.

    摘要翻译： 提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。 通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应 多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。 然后通过在温度和pH值的代谢条件下分别连接到不同的大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。 在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。 还提供了一种制备这种网络的方法。

    Absorbable Multi-Putty Bone Cements and Hemostatic Compositions and Methods of Use
    4.
    发明申请
    Absorbable Multi-Putty Bone Cements and Hemostatic Compositions and Methods of Use 有权
    可吸收的多腻子骨水泥和止血组合物和使用方法

    公开(公告)号：US20140213688A1

    公开(公告)日：2014-07-31

    申请号：US14241142

    申请日：2012-09-05

    申请人： Rao Bezwada ,  Aniq Darr ,  Richard L. Kronenthal ,  John Pacifico

    发明人： Rao Bezwada ,  Aniq Darr ,  Richard L. Kronenthal ,  John Pacifico

    IPC分类号： A61L24/04

    CPC分类号： A61L24/046 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0073 ,  A61L27/18 ,  A61L27/44 ,  A61L27/58 ,  A61L2400/04 ,  A61L2430/02 ,  C08L75/04

    摘要： The present invention relates to absorbable polyurethane compositions suitable for use in bone repair or reconstruction. The present invention relates to the field of polyurethane-based cements, and putties for use in bone hemostasis, repair and reconstruction. The putty compositions may comprise a mixture of two or more individual putties formed through mixing of one or more reactive components and one or more additive (filler) components. Also disclosed herein are methods of using the putty compositions in medical applications to repair gaps or fractures, or to aid in tissue growth or adhesion.

    摘要翻译： 本发明涉及适用于骨修复或重建的可吸收聚氨酯组合物。 本发明涉及聚氨酯类粘固剂领域，以及用于骨止血，修复和重建的油灰。 油灰组合物可以包含通过混合一种或多种反应性组分和一种或多种添加剂（填料）组分形成的两种或多种单独油灰的混合物。 本文还公开了在医疗应用中使用油灰组合物来修复间隙或骨折或帮助组织生长或粘附的方法。