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    Hydroxyphenyl cross-linked macromolecular network and applications thereof
    2.
    发明申请
    Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
    羟基苯基交联大分子网络及其应用

    公开(公告)号：US20050265959A1

    公开(公告)日：2005-12-01

    申请号：US11198803

    申请日：2005-08-05

    申请人： Anthony Calabro ,  Richard Gross ,  Aniq Darr

    发明人： Anthony Calabro ,  Richard Gross ,  Aniq Darr

    IPC分类号： A61K31/74 ,  A61K31/765 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  A61L27/52 ,  C08F261/02 ,  C08G63/48 ,  C08G63/81 ,  C08G63/91 ,  C08G73/02 ,  C08L71/00 ,  C12Q20060101

    CPC分类号： A61L27/52 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  C08G63/81 ,  C08G73/02 ,  C08J3/075 ,  C08L101/14

    摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.

    摘要翻译： 提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。 通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应 多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。 然后通过在温度和pH值的代谢条件下分别连接到不同的大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。 在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。 还提供了一种制备这种网络的方法。

    METAL FRAMING LAYOUT SQUARE AND A METHOD OF USING SAME
    3.
    发明申请
    METAL FRAMING LAYOUT SQUARE AND A METHOD OF USING SAME 审中-公开
    金属框架布局方法及其使用方法

    公开(公告)号：US20150276367A1

    公开(公告)日：2015-10-01

    申请号：US14194064

    申请日：2014-02-28

    申请人： Michael Lamanna ,  Richard Gross

    发明人： Michael Lamanna ,  Richard Gross

    IPC分类号： G01B3/56 ,  G01B3/00 ,  G01B3/04

    CPC分类号： G01B3/566 ,  B25H7/02

    摘要： A metal framing layout square of substantially flat unitary construction and a method for using the same is provided. The square preferably includes an elongated blade, an elongated slot defined in the blade and parallel to the edges of the blade to provide two additional edges for the marking of measurement scales. The tool provides a tongue joined at a right angle to the blade. The metal framing layout square is preferably used with the layout phase of interior metal framed walls, and is directed to a metal framing layout square for use in constructing compound metal framing systems comprising a plurality of predetermined lengths and widths, and has slots which are to allow a user to readily mark a series of layout marks from a starting point to efficiently complete a set of markings for an entire framing structure with minimal need for secondary measuring devices.

    摘要翻译： 提供了基本平坦的单一结构的金属框架布置平面及其使用方法。 该方形优选地包括细长的刀片，限定在刀片中并平行于刀片的边缘的细长槽，以提供用于测量刻度的标记的两个附加边缘。 该工具提供与叶片成直角接合的舌头。 金属框架布置方块优选地与内部金属框架壁的布局阶段一起使用，并且被引导到金属框架布置平面，用于构建包括多个预定长度和宽度的复合金属框架系统，并且具有槽 允许用户从起始点轻松地标记一系列布局标记，以有效地完成整个框架结构的一组标记，同时对二次测量设备的需求最少。

    Method of identifying compounds that modulate myocardial calcium-independent phospholipase A.sub.2 activity
    7.
    发明授权
    Method of identifying compounds that modulate myocardial calcium-independent phospholipase A.sub.2 activity 失效
    鉴定调节心肌钙依赖性磷脂酶A2活性的化合物的方法

    公开(公告)号：US5356787A

    公开(公告)日：1994-10-18

    申请号：US53616

    申请日：1993-04-23

    申请人： Richard Gross

    发明人： Richard Gross

    IPC分类号： C12N9/12 ,  C12N9/20 ,  C12Q1/44 ,  C12Q1/48 ,  C12Q1/34 ,  G01N23/00

    CPC分类号： C12Q1/44 ,  C12N9/12 ,  C12N9/20 ,  C12Q1/48 ,  G01N2333/918 ,  Y10S435/968 ,  Y10S436/804 ,  Y10T436/12

    摘要： A method of identifying compounds that modulate the activity of myocardial calcium-independent phospholipase A.sub.2 is disclosed. In a test assay of the method of the invention, myocardial calcium-independent phospholipase A.sub.2 40 kDa catalytic subunit, 85kDa phosphofructokinase isoform, ATP, a substrate and a test compound are combined and the myocardial calcium-independent phospholipase A.sub.2 activity is determined. The level of activity observed in the test assay is compared to the level of activity generated from a control assay which is similar to the test assay but which does not include the test compound. Essentially pure myocardial calcium-independent phospholipase A.sub.2 85kDa phosphofructokinase isoform is also disclosed.

    摘要翻译： 公开了鉴定调节心肌钙依赖性磷脂酶A2活性的化合物的方法。 在本发明方法的测试测定中，组合心肌钙依赖性磷脂酶A240kDa催化亚基，85kDa磷酸果糖激酶同种型，ATP，底物和测试化合物，并测定心肌钙依赖性磷脂酶A2活性。 将在测试测定中观察到的活性水平与从对照测定产生的活性水平进行比较，其与测试测定类似，但不包括测试化合物。 还公开了本质上纯的心肌钙依赖性磷脂酶A285kDa磷酸果糖激酶同种型。

    STABLE LOW POWER MODE FOR MULTICARRIER TRANSCEIVERS
    9.
    发明申请
    STABLE LOW POWER MODE FOR MULTICARRIER TRANSCEIVERS 有权
    稳定的低功耗模式用于多功能收发器

    公开(公告)号：US20100296555A1

    公开(公告)日：2010-11-25

    申请号：US12739330

    申请日：2008-11-21

    申请人： Christopher Cahill ,  Richard Gross ,  Marcos C. Tzannes

    发明人： Christopher Cahill ,  Richard Gross ,  Marcos C. Tzannes

    IPC分类号： H04B1/38

    CPC分类号： H04M11/062 ,  H04B3/32 ,  H04L1/0001 ,  H04L12/12 ,  H04L27/2601 ,  H04L27/2614 ,  H04L43/08

    摘要： A stable Low Power Mode (LPM) for multicarrier transceivers is described that at least provides transmit power savings while enabling receiver designs that can easily operate without the detrimental effects of fluctuating crosstalk. In one exemplary embodiment, the LPM achieves power savings by reducing the number of used subcarriers without actually performing a power cutback on those subcarriers, thereby allowing a receiver to measure the SNR or noise levels and determine the crosstalk noise on the line regardless of a crosstalking modem being in a LPM or not.

    摘要翻译： 描述了用于多载波收发器的稳定的低功耗模式（LPM），其至少提供发射功率节省，同时使得能够容易地操作的接收机设计而没有波动的串扰的有害影响。 在一个示例性实施例中，LPM通过减少所使用的子载波的数量而实现功率节省，而不在这些子载波上实际执行功率削减，从而允许接收机测量SNR或噪声水平，并确定线路上的串扰噪声，而不考虑串扰 调制解调器处于LPM状态。