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公开(公告)号：US06376539B1
公开(公告)日：2002-04-23
申请号：US09600395
申请日：2000-07-14
申请人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
发明人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
IPC分类号： A61K3134
CPC分类号： C07D493/10 , C07D307/93 , C07D495/10
摘要： The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, cranial cerebral trauma, states of pain or CNS-mediated spasms.
摘要翻译： 本发明涉及新的取代的双环内酯，其制备方法及其用于预防和/或治疗由谷氨酸能系统的过度功能或功能不全引起的疾病，特别是脑缺血性颅脑创伤，状态 的疼痛或CNS介导的痉挛。
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公开(公告)号：US5922708A
公开(公告)日：1999-07-13
申请号：US790869
申请日：1997-02-03
申请人： Bernd Riedl , Dieter Habich , Andreas Stolle , Martin Ruppelt , Stephan Bartel , Walter Guarnieri , Rainer Endermann , Hein-Peter Kroll
发明人： Bernd Riedl , Dieter Habich , Andreas Stolle , Martin Ruppelt , Stephan Bartel , Walter Guarnieri , Rainer Endermann , Hein-Peter Kroll
IPC分类号： A01N43/76 , A61K31/42 , A61K31/44 , A61K31/47 , A61P31/04 , C07D413/04 , C07D413/14 , A61K31/535
CPC分类号： C07D413/04 , C07D413/14 , H04Q2213/13003 , H04Q2213/13196 , H04Q2213/13202 , H04Q2213/13203 , H04Q2213/13209 , H04Q2213/1329 , H04Q2213/13292 , H04Q2213/13299
摘要： The invention relates to novel heteroaryl-oxazolidinones of the general formula (I): ##STR1## in which the substituents are as defined in the description, to processes for their preparation and to their use as drugs, especially as antibacterial drugs.
摘要翻译： 本发明涉及通式（I）的新型杂芳基 - 恶唑烷酮：其中取代基如说明书中所定义，其制备方法及其作为药物，特别是抗菌药物的用途。
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公开(公告)号：US5869659A
公开(公告)日：1999-02-09
申请号：US785145
申请日：1997-01-13
申请人： Andreas Stolle , Dieter Habich , Bernd Riedl , Martin Ruppelt , Stephen Bartel , Walter Guarnieri , Hanno Wild , Rainer Endermann , Hein-Peter Kroll
发明人： Andreas Stolle , Dieter Habich , Bernd Riedl , Martin Ruppelt , Stephen Bartel , Walter Guarnieri , Hanno Wild , Rainer Endermann , Hein-Peter Kroll
IPC分类号： C07D471/04 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/66 , A61K31/675 , A61P31/00 , A61P31/04 , C07D263/58 , C07D291/08 , C07D413/04 , C07D417/04 , C07D417/14 , C07D498/04 , C07D513/04 , C07F9/6539 , C07F9/6558 , C07F9/6561 , C07F9/6581 , C07F9/6584 , C07D413/00 , C07D239/00 , C07D257/08 , C07D487/00
CPC分类号： C07D513/04 , C07F9/6561 , Y02P20/55
摘要： The present invention relates to heteroatom-containing cyclopentanopyridyl-oxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
摘要翻译： 本发明涉及含杂原子的环戊基吡啶基 - 恶唑烷酮，其制备方法及其作为药物的用途，特别是抗菌药物。
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公开(公告)号：US5861413A
公开(公告)日：1999-01-19
申请号：US781002
申请日：1997-01-09
申请人： Dieter Habich , Andreas Stolle , Bernd Riedl , Martin Ruppelt , Stephan Bartel , Walter Guarnieri , Rainer Endermann , Hein-Peter Kroll
发明人： Dieter Habich , Andreas Stolle , Bernd Riedl , Martin Ruppelt , Stephan Bartel , Walter Guarnieri , Rainer Endermann , Hein-Peter Kroll
IPC分类号： C07D221/04 , A61K31/41 , A61K31/42 , A61K31/435 , A61K31/47 , A61P31/04 , C07D215/38 , C07D263/18 , C07D413/04
CPC分类号： C07D413/04 , C07D215/38 , Y02P20/55
摘要： The present invention relates to 2-oxo- and 2-thio-1,2-dihydroquinolinyl-oxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
摘要翻译： 本发明涉及2-氧代-2-和2-硫代-1,2-二氢喹啉基 - 恶唑烷酮，其制备方法及其作为药物，特别是抗菌药物的用途。
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公开(公告)号：US20110152331A1
公开(公告)日：2011-06-23
申请号：US13035638
申请日：2011-02-25
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： A61K31/421 , C07D263/32 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/12 , A61P9/00 , A61P35/00
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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公开(公告)号：US07893281B2
公开(公告)日：2011-02-22
申请号：US12510376
申请日：2009-07-28
申请人： Markus Eckert , Claus Dreisbach , Boris Bosch , Andreas Stolle
发明人： Markus Eckert , Claus Dreisbach , Boris Bosch , Andreas Stolle
IPC分类号： C07D333/20
CPC分类号： C07D333/24 , C07B2200/07
摘要： The invention relates to a process for preparing enantiomerically enriched aryl-aminopropanols and to their use and also to intermediates.
摘要翻译： 本发明涉及制备对映体富集的芳基 - 氨基丙醇的方法及其用途以及中间体。
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公开(公告)号：US07112597B2
公开(公告)日：2006-09-26
申请号：US10949119
申请日：2004-09-22
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： A61K31/425 , C07D277/30
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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公开(公告)号：US20060205723A1
公开(公告)日：2006-09-14
申请号：US11429136
申请日：2006-05-05
申请人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
发明人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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9.发明申请Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 有权茚基乙酸衍生物及其作为药剂，中间体和制备方法的用途公开(公告)号：US20050075338A1
公开(公告)日：2005-04-07
申请号：US10949119
申请日：2004-09-22
申请人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
发明人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
IPC分类号： C12Q1/02 , A61K31/155 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/64 , A61K38/28 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14 , A61P15/00 , A61P17/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P39/06 , A61P43/00 , C07B57/00 , C07B61/00 , C07C51/41 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/736 , C07C69/738 , C07C237/36 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/02 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D413/02
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译： 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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公开(公告)号：US6069160A
公开(公告)日：2000-05-30
申请号：US631516
申请日：1996-04-12
申请人： Andreas Stolle , Dieter Habich , Stephan Bartel , Bernd Riedl , Martin Ruppelt , Hanno Wild , Rainer Endermann , Klaus-Dieter Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
发明人： Andreas Stolle , Dieter Habich , Stephan Bartel , Bernd Riedl , Martin Ruppelt , Hanno Wild , Rainer Endermann , Klaus-Dieter Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
IPC分类号： A61K31/40 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/655 , A61K31/66 , A61P31/04 , C07D263/58 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/04 , C07F9/6558 , C07F9/6584 , A61K31/428 , C07D263/54 , C07D277/62
CPC分类号： C07D263/58 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/04 , C07F9/6558 , C07F9/65842
摘要： The invention relates to heteroatom-containing benzocyclopentaneoxazolidinones, to processes for their preparation and their use as medicaments, especially as antibacterial medicaments.
摘要翻译： 本发明涉及含杂原子的苯并环戊恶唑烷酮，其制备方法及其作为药物的用途，特别是作为抗菌药物。
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