Patent search ap:"Ingo Mugge" Page 1

1.

发明申请
Glucocortioid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权
Title translation: 糖皮质类固醇，其制备方法，药物组合物及其用途

公开(公告)号：US20070060633A1

公开(公告)日：2007-03-15

申请号：US11449231

申请日：2006-06-08

Applicant: Ingo Mugge , David Thomson , Abdelhakim Hammach , Michael Burke , Mark Ralph , Jennifer Kowalski , Joerg Bentzien

Inventor： Ingo Mugge , David Thomson , Abdelhakim Hammach , Michael Burke , Mark Ralph , Jennifer Kowalski , Joerg Bentzien

IPC: A61K31/416 , C07D231/56

CPC classification number: C07D471/04 , C07D209/08 , C07D209/10 , C07D231/56 , C07D235/06 , C07D235/12 , C07D249/18 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06

Abstract: Compounds of Formula (IA) and (IB) wherein R1, R2, R3, A, B, C, D, and E are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Abstract translation: 式（IA）和（IB）的化合物，其中R 1，R 2，R 3，A，B，C，D和 E如本文所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

2.

发明申请
Tec kinase inhibitors 审中-公开
Title translation: Tec激酶抑制剂

公开(公告)号：US20050209284A1

公开(公告)日：2005-09-22

申请号：US11055798

申请日：2005-02-09

Applicant: Joerg Bentzien , Brian Cook , Xiang Li , Ho Lo , Chuk Man , Ingo Mugge , Peter Nemoto , Steven Pullen , Doris Riether , Gregory Roth , Fariba Soleymanzadeh , Hidenori Takahashi , Ji Wang , Andre White , Renee Zindell

Inventor： Joerg Bentzien , Brian Cook , Xiang Li , Ho Lo , Chuk Man , Ingo Mugge , Peter Nemoto , Steven Pullen , Doris Riether , Gregory Roth , Fariba Soleymanzadeh , Hidenori Takahashi , Ji Wang , Andre White , Renee Zindell

IPC: A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/4439 , C07D235/30 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D413/14 , C07D417/02 , C07D417/14 , C07D491/10 , C07D43/02

CPC classification number: C07D235/30 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D491/10

Abstract: Disclosed are compounds of formula(I): wherein Ar1, Ar2, R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的化合物：其中Ar 1，Ar 2，R 1，R 2， R 3，R 4和X a a在本文中定义。本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。还公开了制备这些化合物的方法和包含这些化合物的药物组合物。