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公开(公告)号：US09346484B2
公开(公告)日：2016-05-24
申请号：US14131349
申请日：2012-07-11
申请人： Andreas Raab , Andreas Stahl
发明人： Andreas Raab , Andreas Stahl
IPC分类号： B25B23/00 , B62D3/06 , F16C35/067 , F16B39/32 , F16B23/00
CPC分类号： B62D3/06 , F16B23/00 , F16B23/0069 , F16B39/32 , F16C35/067 , F16C2226/60 , Y10T74/18704
摘要： In a device for releasing a securing screw for a unit in a housing, in particular a pinion unit in a steering gear of a motor vehicle, the securing screw is connected via an external thread to an internal thread in the housing, wherein the securing screw is provided with a latching device, which has latching levers disposed distributed on the circumference of the securing screw, each of which said latching levers is provided with latching lugs disposed on the free ends of the latching levers. The latching lugs latch into teething gaps of a teething geometry of the housing. The latching devices can be connected to a tool in order to release the latching levers having the latching lugs from the latched position by means of a radially inwardly directed movement of the latching levers.
摘要翻译： 在用于释放用于机壳中的单元的紧固螺钉的装置中，特别是机动车辆的舵机中的小齿轮单元，固定螺钉通过外螺纹连接到壳体中的内螺纹，其中固定螺钉 设置有闩锁装置，其具有分配在固定螺钉的圆周上的闩锁杆，每个闩锁杆设置有设置在闩锁杆的自由端上的闩锁凸耳。 锁定凸耳锁定到壳体的出牙几何形状的出牙缝隙中。 闩锁装置可以连接到工具，以便借助于锁定杆的径向向内的运动来将具有闩锁凸耳的闩锁杆从闩锁位置释放。
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公开(公告)号：US20140144264A1
公开(公告)日：2014-05-29
申请号：US14131349
申请日：2012-07-11
申请人： Andreas Raab , Andreas Stahl
发明人： Andreas Raab , Andreas Stahl
IPC分类号： B62D3/06
CPC分类号： B62D3/06 , F16B23/00 , F16B23/0069 , F16B39/32 , F16C35/067 , F16C2226/60 , Y10T74/18704
摘要： In a device for releasing a securing screw for a unit in a housing, in particular a pinion unit in a steering gear of a motor vehicle, the securing screw is connected via an external thread to an internal thread in the housing, wherein the securing screw is provided with a latching device, which has latching levers disposed distributed on the circumference of the securing screw, each of which said latching levers is provided with latching lugs disposed on the free ends of the latching levers. The latching lugs latch into toothing gaps of a toothing geometry of the housing. The latching device can be connected to a tool in order to release the latching levers having the latching lugs from the latched position by means of a radially inwardly directed movement of the latching levers.
摘要翻译： 在用于释放用于机壳中的单元的紧固螺钉的装置中，特别是机动车辆的舵机中的小齿轮单元，固定螺钉通过外螺纹连接到壳体中的内螺纹，其中固定螺钉 设置有闩锁装置，其具有分配在固定螺钉的圆周上的闩锁杆，每个闩锁杆设置有设置在闩锁杆的自由端上的闩锁凸耳。 锁定凸耳卡入壳体的齿形几何形状的齿间隙中。 闩锁装置可以连接到工具上，以便借助于锁定杆的径向向内的移动将具有闩锁凸耳的闩锁杆从闩锁位置释放。
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公开(公告)号：US06300096B1
公开(公告)日：2001-10-09
申请号：US09232197
申请日：1999-01-14
IPC分类号： C12P2106
CPC分类号： C12N9/93 , C07K2319/02 , G01N2800/044
摘要： A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 一系列脂肪酸转运蛋白（FATP）介导长链脂肪酸（LCFAs）跨细胞膜转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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4.发明授权公开(公告)号：US07033772B1
公开(公告)日：2006-04-25
申请号：US09405504
申请日：1999-09-23
CPC分类号： G01N33/92 , G01N2333/70596 , G01N2500/00 , G01N2800/044
摘要： A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 一系列脂肪酸转运蛋白（FATP）介导长链脂肪酸（LCFAs）跨细胞膜转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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公开(公告)号：US06288213B1
公开(公告)日：2001-09-11
申请号：US09232200
申请日：1999-01-14
IPC分类号： C07K1447
CPC分类号： C12N9/93 , C07K2319/02 , G01N2800/044
摘要： A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 一系列脂肪酸转运蛋白（FATP）介导长链脂肪酸（LCFAs）跨细胞膜转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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公开(公告)号：US06284487B1
公开(公告)日：2001-09-04
申请号：US09232191
申请日：1999-01-14
申请人： Andreas Stahl , David J. Hirsch , Harvey F. Lodish
发明人： Andreas Stahl , David J. Hirsch , Harvey F. Lodish
IPC分类号： C12N1512
CPC分类号： C12N9/93 , C07K2319/02 , G01N2800/044
摘要： A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ.
摘要翻译： 一系列脂肪酸转运蛋白（FATP）介导长链脂肪酸（LCFAs）跨细胞膜转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP的FATP转运功能的抑制剂或增强剂来改变LCFA摄取可以降低或增加作为脂肪可获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等指导给器官的方法。
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公开(公告)号：US20140199239A1
公开(公告)日：2014-07-17
申请号：US13695988
申请日：2011-05-16
申请人： Carolyn Ruth Bertozzi , Andreas Stahl , Amy Helene Henkin , Elena A. Dubikovskaya , Allison Cohen
发明人： Carolyn Ruth Bertozzi , Andreas Stahl , Amy Helene Henkin , Elena A. Dubikovskaya , Allison Cohen
CPC分类号： A61K49/0052 , A61K51/0453 , A61K51/0482 , C07D257/02 , C07D277/28 , C07D277/64 , C07D417/04 , C07D487/04 , C12Q1/66
摘要： The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.
摘要翻译： 本公开提供了脂质 - 探针化合物和包含该化合物的组合物。 主题脂质 - 探针化合物对于也提供的各种成像应用是有用的。
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公开(公告)号：US06657049B1
公开(公告)日：2003-12-02
申请号：US09232195
申请日：1999-01-14
申请人： Andreas Stahl
发明人： Andreas Stahl
IPC分类号： C07K1600
CPC分类号： C12N9/93 , C07K2319/02 , G01N2800/044
摘要： Isolated antibodies and antigen-binding fragments thereof which specifically bind to members of a family of fatty acid transport proteins (FATPs) which mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells are described. These proteins exhibit different expression patterns among the organs of mammals. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 描述了特异性结合脂肪酸转运蛋白家族（FATP）的成员的分离的抗体及其抗原结合片段，其介导跨细胞膜转运到细胞中的长链脂肪酸（LCFAs）的转运。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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公开(公告)号：US06348321B1
公开(公告)日：2002-02-19
申请号：US09232201
申请日：1999-01-14
IPC分类号： G01N3353
CPC分类号： C12N9/93 , C07K2319/02
摘要： A family of fatty acid transport proteins (FATPS) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 一系列脂肪酸转运蛋白（FATPS）介导长链脂肪酸（LCFAs）在细胞膜中的转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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