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1.发明授权Method for treating tension type headaches or headaches associated with drugs or their withdrawal 失效治疗与药物或其戒断有关的紧张型头痛或头痛的方法
公开(公告)号：US5376672A
公开(公告)日：1994-12-27
申请号：US30387
申请日：1993-04-06
Applicant: Alison J. Pilgrim
Inventor： Alison J. Pilgrim
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61P25/04 , A61P29/00 , C07D209/16 , A61K31/405
CPC classification number: A61K31/40 , Y10S514/929
Abstract: The present invention provides a new medical use for 3-[2-(dimethylamino)-ethyl]-N-methyl-1H-indole-5-methanesulphonamide and physiologically acceptable salts and solvates thereof in the treatment of tension-type headache and headache associated with substances or their withdrawal.
Abstract translation: PCT No.PCT / GB91 / 01768 Sec。 371日期：1993年4月6日 102（e）日期1993年4月6日PCT 1991年10月11日PCT公布。 出版物WO92 / 06688 本发明提供了3- [2-（二甲基氨基） - 乙基] -N-甲基-1H-吲哚-5-甲磺酰胺及其生理学上可接受的盐和溶剂化物在治疗中的新的医学用途 紧张型头痛和与物质或其戒断有关的头痛。
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公开(公告)号：US09040483B2
公开(公告)日：2015-05-26
申请号：US13551526
申请日：2012-07-17
Applicant: Paul F. Glidden , Alison J. Pilgrim , Stephen R. Hanson
Inventor： Paul F. Glidden , Alison J. Pilgrim , Stephen R. Hanson
IPC: A61P7/02 , C07D239/72 , A61K9/48 , A61K9/50 , A61K31/00 , A61K31/519 , A61L27/02 , A61L27/20 , A61L27/22 , A61L27/34 , A61L27/54 , A61L27/56 , C07D487/04
CPC classification number: A61K9/1676 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2081 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K31/00 , A61K31/519 , A61L27/025 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61L2300/622 , A61L2300/63 , A61L2420/08 , C07D239/72 , C07D487/04 , C08L3/04 , C08L1/02
Abstract: Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
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3.发明申请公开(公告)号：US20130022671A1
公开(公告)日：2013-01-24
申请号：US13551526
申请日：2012-07-17
Applicant: Paul F. Glidden , Alison J. Pilgrim , Stephen R. Hanson
Inventor： Paul F. Glidden , Alison J. Pilgrim , Stephen R. Hanson
IPC: A61K9/00 , A61K9/20 , A61K31/519 , A61P9/00 , A61P7/00 , A61P3/10 , A61P3/06 , A61P9/12 , A61P9/10 , A61K31/56 , A61K38/17 , A61K38/54 , A61K39/395 , A61K31/704 , A61K38/20 , A61K38/21 , A61K9/48
CPC classification number: A61K9/1676 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2081 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K31/00 , A61K31/519 , A61L27/025 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61L2300/622 , A61L2300/63 , A61L2420/08 , C07D239/72 , C07D487/04 , C08L3/04 , C08L1/02
Abstract: Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
Abstract translation: 本发明提供了通过包括阿那格雷和阿那格雷衍生物在内的给药试剂抑制血管闭塞事件（包括栓塞）的方法来治疗受试者的预防和治疗方法，其将循环血小板数量降低到正常水平或低于正常水平。 提供包含这些试剂的方法和药物制剂。
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4.发明申请Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor 审中-公开降低血小板循环水平的试剂的控释组合物及其方法公开(公告)号：US20090324710A1
公开(公告)日：2009-12-31
申请号：US12456443
申请日：2009-06-16
Applicant: Paul F. Glidden , Alison J. Pilgrim , Stephen R. Hanson
Inventor： Paul F. Glidden , Alison J. Pilgrim , Stephen R. Hanson
CPC classification number: A61K9/1676 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2081 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K31/00 , A61K31/519 , A61L27/025 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61L2300/622 , A61L2300/63 , A61L2420/08 , C07D239/72 , C07D487/04 , C08L3/04 , C08L1/02
Abstract: Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
Abstract translation: 本发明提供了通过包括阿那格雷和阿那格雷衍生物在内的给药试剂抑制血管闭塞事件（包括栓塞）的方法来治疗受试者的预防和治疗方法，其将循环血小板数量降低到正常水平或低于正常水平。 提供包含这些试剂的方法和药物制剂。
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